Magnesium can reduce neuroinflammation and cognitive decline – Sept 2024

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Neuroprotective effects of magnesium: implications for neuroinflammation and cognitive decline

Front. Endocrinol., 24 September 2024 Volume 15 - 2024 | https://doi.org/10.3389/fendo.2024.1406455
Veer PatelVeer Patel1 Nuraly S. Akimbekov,Nuraly S. Akimbekov2,3 William B. Grant William B. Grant4 Carolyn DeanCarolyn Dean5Xiaoqian FangXiaoqian Fang6 Mohammed S. Razzaque,*Mohammed S. Razzaque1,7*

• 1Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, United States
• 2Scientific-Practical Center, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
• 3Sustainability of Ecology and Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan
• 4Sunlight, Nutrition, and Health Research Center, San Francisco, CA, United States
• 5New Capstone, Inc., Mooresville, NC, United States
• 6Department of Neuroscience, School of Medicine, University of Texas Rio Grande Valley (UTRGV), Edinburg, TX, United States
• 7Department of Medical Education, School of Medicine, University of Texas Rio Grande Valley (UTRGV), Edinburg, TX, United States

Neurodegenerative diseases, which are characterized by progressive neuronal loss and cognitive decline, are a significant concern for the aging population. Neuroinflammation, a shared characteristic of these diseases, is implicated in their pathogenesis. This article briefly summarizes the role of magnesium, an essential mineral involved in numerous enzymatic reactions and critical for neuronal bioactivity, in the context of neuroinflammation and cognitive decline. The potential neuroprotective effects of magnesium, including the mechanisms of neuroprotection by magnesium through maintaining neuronal ion homeostasis, reducing inflammation, and preventing excitotoxicity, are also described. Additionally, we discuss the impact of inadequate magnesium on neuroinflammation and its potential as a therapeutic agent for attenuating cognitive decline to improve neurodegenerative conditions.
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VitaminDWiki - 8 studies in both categories Cognitive and Magnesium

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VitaminDWiki - 4 studies in both categories Inflammation and Magnesium

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VitaminDWiki – Magnesium and Vitamin D contains

369 items in category, see also

• Overview Magnesium and vitamin D
• Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023
• The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023
• Magnesium deficiency – causes and symptoms – May 2016
• Magnesium Depletion Score predicts increased risk of various health problems
• Vitamins and Metals needed by the Immune System – Jan 2020
• Magnesium: intake decreased, difficult to measure in body – Sept 2018
• Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
• Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
• Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
• Magnesium is great for health, topical much faster than oral, MgCl2 is the best – 2019
• Magnesium is important for health but levels are low – July 2018
• How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol
• Magnesium etc. reduced in crops (must supplement) – 2009

Magnesium and Vitamin D

• Intracellular Magnesium and Vitamin D - a few studies
• Vitamin D and Magnesium need each other - many studies
• Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
• 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020
• Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018
• Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
• Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017
• Vitamin D Cofactors in a nutshell
• Magnesium and Vitamin D - similar, different and synergistic

12+ VitaminDWiki Magnesium pages have MANY STUDIES in the title
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VitaminDWiki – Inflammation category:

175 items total

Example studies

• Vitamin D reduces autoimmune, cardio, and metabolic Inflammation – Nov 2024
• Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
• COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
• Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020
• Vitamin D reduces inflammation in critically ill patients – Sept 2020
• Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
• How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
• CYTOKINE in VitaminDWiki 12 titles as of July 2023
• 17 pages in VitaminDWiki had REACTIVE or CRP in title as of July 2023
• Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014

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VitaminDWiki – Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis Feb 2022