Vitamin D, Hospital-Acquired Infections and Mortality in Critically Ill Patients: Emerging Evidence
Chapter: Annual Update in Intensive Care and Emergency Medicine 2017 https://doi.org/10.1007/978-3-319-51908-1_15
Part of the series Annual Update in Intensive Care and Emergency Medicine pp 169-183
G. De Pascale, M. Antonelli Massimo.Antonelli at unicatt.it, S. A. Quraishi
25(OH)D: 25-hydroxyvitamin D; ED: emergency department; HABSI: hospital-acquire bloodstream infection; ICU: intensive care unit; SAPS II: Simplified Acute Physiology Score II;APACHE II: Acute Physiology and Chronic Health Evaluation II; SSI: skin and soft tissue infection; CDI: Clostridium difficile infection; OR: odds ratio; CI: confidence interval
- Vitamin D and Glutamine reduced Trauma Center deaths by half – Matthews March 2017
- Vitamin D deficiency in pediatric critical illness: Time to move on from observational studies – Nov 2016
- Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- Hospitalized cats 8X more likely to die if low vitamin D (Vit. D helps humans too) – May 2015
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
Trauma and surgery category starts with the following
Trauma and Surgery category hasLarge dose Vitamin D before surgery was found to help by 35 studies
Vitamin D is needed before most surgeries – many studies and RCTs
4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
Sepsis is both prevented and treated by Vitamin D - many studies
Thyroidectomy and Vitamin D - many studies
Orthopaedic surgeries need Vitamin D – many studies
Cancer - After diagnosis chemotherapy
TBI OR "Traumatic Brain Injury - 21 in title as of Sept 2022
Superbug (Clostridium difficile) Infections strongly associated with low vitamin D - many studies
Glutamine and Omega-3 have also been proven to help several traumas/surgeries
Note: Vitamin D also prevents the need for various surgeries and Omega-3 prevents many concussions/TBI
Trauma and Surgery is associated with 22 other VitaminDWiki categories
Such as loading dose 33, Mortality 23, Infant-Child 21 Intervention 19 Cardiovascular 13, Injection 13 in Sept 2022
 Download the PDF from Sci-Hub from VitaminDWiki
References
- 1. Klevens RM, Edwards JR, Richards CL Jr et al (2007) Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 122:160–166CrossRefPubMedPubMedCentral
- 2. De Pascale G, Cutuli SL, Pennisi MA, Antonelli M (2013) The role of mannose-binding lectin in severe sepsis and septic shock. Mediators Inflamm 2013:625083CrossRef
- 3. Quraishi SA, Camargo CA Jr (2012) Vitamin D in acute stress and critical illness. Curr Opin Clin Nutr Metab Care 15:625–634CrossRefPubMedPubMedCentral
- 4. Quraishi SA, Bittner EA, Blum L, McCarthy C, Bhan I, Camargo CA Jr (2014) Prospective study of vitamin D status at initiation of care in critically ill surgical patients and risk of 90-day mortality. Crit Care Med 42:1365–1371CrossRefPubMedPubMedCentral
- 5. Jeng L, Yamshchikov AV, Judd SE et al (2009) Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med 7:28CrossRefPubMedPubMedCentral
- 6. Danai PA, Sinha S, Moss M, Haber MJ, Martin GS (2007) Seasonal variation in the epidemiology of sepsis. Crit Care Med 35:410–415CrossRefPubMed
- 7. Lucidarme O, Messai E, Mazzoni T, Arcade M, du Cheyron D (2010) Incidence and risk factors of vitamin D deficiency in critically ill patients: results from a prospective observational study. Intensive Care Med 36:1609–1611CrossRefPubMed
- 8. Horiuchi H, Nagata I, Komoriya K (1991) Protective effect of vitamin D3 analogues on endotoxin shock in mice. Agents Actions 33:343–348CrossRefPubMed
- 9. Ginde AA, Camargo CA Jr, Shapiro NI (2011) Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerg Med 18:551–554CrossRefPubMed
- 10. Nair P, Lee P, Reynolds C et al (2013) Significant perturbation of vitamin D-parathyroid-calcium axis and adverse clinical outcomes in critically ill patients. Intensive Care Med 39:267–274CrossRefPubMed
- 11. Leaf DE, Raed A, Donnino MW, Ginde AA, Waikar SS (2014) Randomized controlled trial of calcitriol in severe sepsis. Am J Respir Crit Care Med 190:533–541CrossRefPubMedPubMedCentral
- 12. Barnett N, Zhao Z, Koyama T et al (2014) Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case-control study. Ann Intensive Care 4:5CrossRefPubMedPubMedCentral
- 13. Cecchi A, Bonizzoli M, Douar S et al (2011) Vitamin D deficiency in septic patients at ICU admission is not a mortality predictor. Minerva Anestesiol 77:1184–1189
- 14. Lange N, Litonjua AA, Gibbons FK, Giovannucci E, Christopher KB (2013) Pre-hospital vitamin D concentration, mortality, and bloodstream infection in a hospitalized patient population. Am J Med 126:e19–27CrossRef
- 15. Nguyen HB, Eshete B, Lau KH, Sai A, Villarin M, Baylink D (2013) Serum 1,25-dihydroxyvitamin D: an outcome prognosticator in human sepsis. PLoS One 8:e64348CrossRefPubMedPubMedCentral
- 16. Moromizato T, Litonjua AA, Braun AB, Gibbons FK, Giovannucci E, Christopher KB (2014) Association of low serum 25-hydroxyvitamin d levels and sepsis in the critically ill. Crit Care Med 42:97–107CrossRefPubMed
- 17. Flynn L, Zimmerman LH, McNorton K et al (2012) Effects of vitamin D deficiency in critically ill surgical patients. Am J Surg 203:379–382CrossRefPubMed
- 18. Amrein K, Zajic P, Schnedl C et al (2014) Vitamin D status and its association with season, hospital and sepsis mortality in critical illness. Crit Care 8:R47CrossRefPubMedPubMedCentral
- 19. Braun A, Chang D, Mahadevappa K et al (2011) Association of low serum 25-hydroxyvitamin D levels and mortality in the critically ill. Crit Care Med 39:671–677CrossRefPubMedPubMedCentral
- 20. Quraishi SA, Litonjua AA, Moromizato T et al (2013) Association between prehospital vitamin D status and hospital-acquired bloodstream infections. Am J Clin Nutr 98:952–959CrossRefPubMedPubMedCentral
- 21. de Haan K, Groeneveld AB, de Geus HR, Egal M, Struijs A (2014) Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis. Crit Care 18:660CrossRefPubMedPubMedCentral
- 22. Fish E, Beverstein G, Olson D, Reinhardt S, Garren M, Gould J (2010) Vitamin D status of morbidly obese bariatric surgery patients. J Surg Res 164:198–202CrossRefPubMed
- 23. Flancbaum L, Belsley S, Drake V, Colarusso T, Tayler E (2006) Preoperative nutritional status of patients undergoing Roux-en-Y gastric bypass for morbid obesity. J Gastrointest Surg 10:1033–1037CrossRefPubMed
- 24. Bogunovic L, Kim AD, Beamer BS, Nguyen J, Lane JM (2010) Hypovitaminosis D in patients scheduled to undergo orthopaedic surgery: a single-center analysis. J Bone Joint Surg Am 92(13):2300–2304CrossRefPubMedPubMedCentral
- 25. Maier GS, Horas K, Seeger JB, Roth KE, Kurth AA, Maus U (2015) Vitamin D insufficiency in the elderly orthopaedic patient: an epidemic phenomenon. Int Orthop 39:787–792CrossRefPubMed
- 26. Quraishi SA, Bittner EA, Blum L, Hutter MM, Camargo CA Jr (2014) Association between preoperative 25-hydroxyvitamin D level and hospital-acquired infections following Roux-en-Y gastric bypass surgery. JAMA Surg 149:112–118CrossRefPubMedPubMedCentral
- 27. Zittermann A, Kuhn J, Ernst JB et al (2016) Circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations and postoperative infections in cardiac surgical patients: The CALCITOP-Study. PLoS One 11:e0158532CrossRefPubMedPubMedCentral
- 28. Quraishi SA, Litonjua AA, Moromizato T et al (2015) Association between prehospital vitamin D status and hospital-acquired Clostridium difficile infections. JPEN Parenter Enteral Nutr 39:47–55
- 29. Ananthakrishnan AN, Cagan A, Gainer VS et al (2014) Higher plasma vitamin D is associated with reduced risk of Clostridium difficile infection in patients with inflammatory bowel diseases. Aliment Pharmacol Ther 39:1136–1142CrossRefPubMedPubMedCentral
- 30. Wang WJ, Gray S, Sison C et al (2014) Low vitamin D level is an independent predictor of poor outcomes in Clostridium difficile-associated diarrhea. Therap Adv Gastroenterol 7:14–19
- 31. Wilden GM van der, Fagenholz P et al (2015) Vitamin D status and severity of Clostridium difficile infections: a prospective cohort study in hospitalized adults. JPEN J Parenter Enteral Nutr 39:465–470CrossRefPubMed
- 32. Wong KK, Lee R, Watkins RR, Haller N (2016) Prolonged Clostridium difficile infection may be associated with vitamin D deficiency. J Parenter Enteral Nutr 40:682–687CrossRef
- 33. Furuya-Kanamori L, Wangdi K, Yakob L et al (2015) 25-hydroxyvitamin D concentrations and Clostridium difficile infection: A meta-analysis. JPEN J Parenter Enteral Nutr Dec 23, Epub ahead of print
- 34. Hertting O, Holm Å, Lüthje P et al (2010) Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLoS One 14:e15580CrossRef
- 35. Quraishi SA, Bittner EA, Christopher KB, Camargo CA Jr (2013) Vitamin D status and community-acquired pneumonia: results from the third National Health and Nutrition Examination Survey. PLoS One 8:e81120CrossRefPubMedPubMedCentral
- 36. Remmelts HH, van de Garde EM et al (2012) Addition of vitamin D status to prognostic scores improves the prediction of outcome in community-acquired pneumonia. Clin Infect Dis 55:1488–1494CrossRefPubMed
- 37. Dancer RC, Parekh D, Lax S et al (2015) Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax 70:617–624CrossRefPubMedPubMedCentral
- 38. Türkoğlu M, Aygencel G, Dizbay M et al (2013) Is vitamin D deficiency associated with development of Acinetobacter baumannii infections in critically ill patients? J Crit Care 28:735–740CrossRefPubMed
- 39. Anty R, Tonohouan M, Ferrari-Panaia P et al (2014) Low levels of 25-hydroxy vitamin D are independently associated with the risk of bacterial infection in cirrhotic patients. Clin Transl Gastroenterol 5:e56CrossRefPubMedPubMedCentral
- 40. Amrein K, Quraishi SA, Litonjua AA et al (2014) Evidence for a U-shaped relationship between pre-hospital vitamin D status and mortality: a cohort study. J Clin Endocrinol Metab 99:1461–1469CrossRefPubMedPubMedCentral
- 41. McKinney JD, Bailey BA, Garrett LH, Peiris P, Manning T, Peiris AN (2011) Relationship between vitamin D status and ICU outcomes in veterans. J Am Med Dir Assoc 12:208–211CrossRefPubMed
- 42. Venkatram S, Chilimuri S, Adrish M, Salako A, Patel M, Diaz-Fuentes G (2011) Vitamin D deficiency is associated with mortality in the medical intensive care unit. Crit Care 15:R292CrossRefPubMedPubMedCentral
- 43. Braun AB, Litonjua AA, Gibbons FK, Litonjua AA, Giovannucci E, Christopher KB (2012) Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality. Crit Care Med 40:179
- 44. Aygencel G, Turkoglu M, Tuncel AF, Candır BA, Bildacı YD, Pasaoglu H (2013) Is vitamin d insufficiency associated with mortality of critically ill patients? Crit Care Res Pract 2013:856747PubMedPubMedCentral
- 45. Arnson Y, Gringauz I, Itzhaky D, Amital H (2012) Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patients. QJM 105:633–639CrossRefPubMed
- 46. Higgins DM, Wischmeyer PE, Queensland KM, Sillau SH, Sufit AJ, Heyland DK (2012) Relationship of vitamin D deficiency to clinical outcomes in critically ill patients. JPEN J Parenter Enteral Nutr 36:713–720
- 47. Matthews LR, Ahmed Y, Wilson KL, Griggs DD, Danner OK (2012) Worsening severity of vitamin D deficiency is associated with increased LOS, surgical intensive care unit cost, and mortality rate in surgical intensive care unit patients. Am J Surg 204:37–43CrossRefPubMedPubMedCentral
- 48. De Pascale G, Vallecoccia MS, Schiattarella A et al (2016) Clinical and microbiological outcome in septic patients with extremely low 25-hydroxyvitamin D levels at initiation of critical care. Clin Microbiol Infect 22:456CrossRefPubMed
- 49. Quraishi SA, De Pascale G, Needleman JS et al (2015) Effect of cholecalciferol supplementation on vitamin D Status and cathelicidin levels in sepsis: a randomized, placebo-controlled trial. Crit Care Med 43:1928–1937CrossRefPubMedPubMedCentral
- 50. Amrein K, Sourij H, Wagner G et al (2011) Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebo-controlled pilot study. Crit Care 15:R104CrossRefPubMedPubMedCentral
- 51. Amrein K, Schnedl C, Holl A et al (2014) Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA 312:1520–1530CrossRefPubMed
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