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Revisiting Vitamin D Guidelines – Holick Oct 2024


Revisiting Vitamin D Guidelines: A Critical Appraisal of The Literature

Endocrine Practice https://doi.org/10.1016/j.eprac.2024.10.011 PDF behind Paywall
Michael F. Holick PhD MD

Dr. Holick's data charted by GrassrootsHealth
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A, PTH related to serum concentrations of 25(OH)D with permission, [19 ]
B, Seasonal variation in serum concentrations of 25(OH)D and PTH with [21] open access,
C, Osteomalacia measured as osteoid volume/bone volume with permission, [22]
D, Pre-eclampsia related to serum concentrations of 25(OH)D with permission, [23]
E, Gestational week at birth related to serum concentrations of 25(OH)D with permission,[24]
F, Peripheral Artery Disease associated serum concentrations of 25(OH)D with permission,[25]
G, COVID infectivity related to serum concentrations of 25(OH)D open access,[26]
H, Latitude associated with incidence of type 1 diabetes with permission,[27]
I, Breast cancer incidence associated with serum concentrations of 25(OH)D with permission,[28]
J, Geographic variation in breast cancer mortality and exposure to solar radiation with permission,[29]
K, All-cause mortality related to serum concentrations of 25(OH)D with permission,[30]
L, Serum concentrations of 25(OH)D associated with vitamin D supplementation open access, and [31]
M, Serum concentrations of 25(OH)D associated with vitamin D supplementation related to
    underweight, normal weight, and overweight open access.[31]

Highlights

  • Provided a perspective of the 2024 Endocrine Society’s Guidelines on Vitamin D compared to and contrasted to the 2011 Endocrine Society’s Guidelines on Vitamin D.
  • Reviewed the 2024 Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline for public health for the extra skeletal health benefits of empiric vitamin D supplementation.
  • Reviewed the 2011 Evaluation, Treatment and Prevention of Vitamin D Deficiency Endocrine Society’s Clinical Guidelines.
  • Reviewed the literature including associations studies and other biochemical, histological and pathological studies that support a serum concentration of 25-hydroxyvitamin D of at least 30 ng/mL not only for bone health but also for extra skeletal health benefits.
  • Provides guidance for how much vitamin D is required to obtain and maintain a serum concentration of 25-hydroxyvitamin D in the preferred range of 40-60 ng/mL for maximum health as recommended by the Endocrine Society’s Guidelines on vitamin D 2011.
  • Reviewed studies relating reduction in clinical outcomes and serum concentrations of 25-hydroxyvitamin D

The goal of this Review is to compare the 2024 and 2011 Endocrine Society’s Clinical Guidelines on Vitamin D. The 2024 Guideline made recommendations for the general healthy population for skeletal and extra skeletal health benefits of vitamin D. This contrasts with the 2011 Guidelines which provided clinicians with guidance for how to evaluate and treat patients with vitamin D deficiency and prevent recurrence. The 2024 Guideline focused on randomized controlled trials and ignored association studies and other studies that have supported the skeletal and extraskeletal health the benefits of vitamin D. The 2024 Guideline recommended empiric vitamin D in children and adolescents aged 1 to 18 years to reduce risk of upper respiratory tract infections, pregnant women to improve pregnancy related outcomes, prediabetic patients to reduce risk of diabetes and to improve mortality in those over 75 years.
These guidelines do not apply to individuals with abnormalities in calcium, phosphate, vitamin D and bone metabolism which were provided in the 2011 Guidelines. For nonpregnant adults up to the age of 75 they recommend the Dietary Reference Intakes of 600 IUs, and 800 IUs as recommended by The Institute of Medicine.
Association studies have suggested that to obtain maximum extraskeletal benefits from vitamin D including reducing risk of upper respiratory tract infection for children and adults, autoimmune disorders, preeclampsia, low birth weight, neonatal dental caries and deadly cancers that circulating concentrations of 25-hydroxyvitamin D should be at least 30 ng/mL with a preferred range of 40-60 ng/mL as recommended by the 2011 Guidelines.

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References
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VitaminDWiki – Consensus Vitamin D category contains:

71 Vitamin D consensus publications

57+ VitaminDWiki pages have HOLICK in the title

The list is automatically updated

Items found: 57
Title Modified
Revisiting Vitamin D Guidelines – Holick Oct 2024 15 Nov, 2024
Vitamin D interview and transcript - Dr. Holick Aug 2024 06 Sep, 2024
Dr. Holick interview with transcript - May 2024 05 May, 2024
Podcast by Dr. Holick on vitamin D - Feb 2011 05 May, 2024
Prostate Cancer - interview of Dr. Holick by Baggerly - video and transcript Jan 2024 05 May, 2024
Should You Take A Vitamin D Supplement - Dr Holick transcript Oct 2022 28 Nov, 2023
Vitamin D: 100 year anniversary of discovery – Holick Jan 2023 23 Jan, 2023
Vitamin D and neurocognitive function – Holick April 2014 21 Oct, 2022
Vitamin D and neurocognitive function – Holick Oct 2022 21 Oct, 2022
How Sensible Sun Exposure Benefits Your Health -Holick interview May 2022 30 May, 2022
UV, sunshine, and vitamin D (87 charts) - Holick March 2013 11 Jan, 2022
Vitamin D and COVID-19: a narrative review - Holick - Jan 4, 2022 10 Jan, 2022
Low Vitamin D in infants - video interview of Dr. Holick - May 2017 11 Dec, 2021
Hospital has banned Dr. Holick due to testifying in cases of infants with broken bones- August, 2021 03 Aug, 2021
Vitamin D Is Not as Toxic as Was Once Thought – Holick May 2015 20 Mar, 2021
Vitamin D, Zinc, etc. look promising for COVID-19 (Holick) - Jan 25, 2021 28 Jan, 2021
Call to action: Vitamin D to prevent of treat hip fracture (50,000 weekly for 8 weeks, then bi-weekly) – Holick July 2020 11 Dec, 2020
Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020 17 Sep, 2020
Immunologic Effects of Vitamin D on Human Health and Disease - Holick July 2020 15 Jul, 2020
The vitamin D deficiency pandemic – Holick May 2017 21 Jan, 2020
Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019 25 Jun, 2019
Diagnosis and treatment of osteopenia – Holick 2010 10 Dec, 2018
Photobiology of Vitamin D – free chapter in book – Holick 2010 17 Nov, 2018
Kaiser Health News wrote a damning article about Dr. Holick and Vitamin D, NYT published it – Aug 2018 20 Aug, 2018
Vitamin D - at least 4,000 IU to achieve 40-60 ng and reduce risk of early death – Holick June 2018 04 Jun, 2018
Role of Vitamin D in the Pathogenesis of Diabetes – Holick July 2017 16 Jul, 2017
The risks and benefits of sun exposure – Holick Oct 2016 05 Jan, 2017
Vitamin D presentation by Dr. Holick Spring 2012 08 Mar, 2016
Holick interview by Mercola on Vitamin D – Dec 2015 17 Jan, 2016
Major review of Vitamin D – Holick Feb 2013 27 Dec, 2015
Vitamin D Global Perspective - Holick June 2013 27 Dec, 2015
Dr. Holick video on vitamin D - March 2013 27 Dec, 2015
Vitamin D from 1940 and into the future – Holick video Nov 2013 28 Nov, 2015
Vitamin D review – Holick Jan 2013 24 Sep, 2015
Go ahead, soak up some sun (but don’t burn) – Holick July 2015 01 Aug, 2015
Chicago Sun Times on vitamin D: Depression, chest pain, fibromyalgia, Holick, 3000 IU without test - May 2010 15 Jul, 2015
Chicago Times on vitamin D: Depression, chest pain, fibromyalgia, Holick, 3000 IU without test - May 2010 15 Jul, 2015
Live Longer with Vitamin D - Holick March 2015 17 May, 2015
Sunlight and Your Health: An EnLIGHTening Perspective - Holick Video Dec 2014 14 Mar, 2015
Less sun means more disease -Grant, Holick, Cannell, et al Feb 2015 05 Mar, 2015
Cancer, Sunlight, and Vitamin D - Holick Oct 2014 06 Oct, 2014
Environmental factors that influence the cutaneous production of vitamin D – Holick 1995 06 Jan, 2014
If You're Low in This Nutrient, It Doubles Your Odds of Many Cancers– Interview Dr. Holick Oct 2013 23 Dec, 2013
Patent application for a skin cream which enhances production of vitamin D – Holick July 2013 24 Nov, 2013
Vitamin D update – Holick Sept 2013 11 Nov, 2013
Vitamin D, Sunlight and Cancer Connection – Holick Jan 2013 11 Aug, 2013
Vitamin D encyc. - 2nd edition, Holick - April 2013 02 Mar, 2013
Major review of Vitamin D – Holick 2013 part II 08 Feb, 2013
Vitamin D: A D-Lightful Vitamin for Health – Holick Dec 2012 07 Jan, 2013
Evidence for vitamin D – Holick June 2012 23 Nov, 2012
VITAMIN D: A D-LIGHTFUL SOLUTION FOR GOOD HEALTH – Holick 2012 30 Oct, 2012
Michael Holick – reduce health care costs 25 percent – interview Sept 2010 07 Oct, 2012
High Prevalence of Vitamin D Inadequacy - Holick Mayo Clinic 2006 14 May, 2012
Professional book on Vitamin D - Editor Holick 2010 27 Aug, 2011
Vitamin D Holick – Jan 2011 29 Mar, 2011
Vitamin D is essential to the modern indoor lifestyle – interview Holick Oct 2010 09 Oct, 2010
Interview of pioneer in Vitamin D research - Holick LEF Sept 2010 08 Sep, 2010

40-150 ng of Vitamin D needed to treat health problems

Vitamin D Treats
150 ng Multiple Sclerosis *
80 ng Cluster Headache *
Reduced office visits by 4X *
70 ngSleep *
60 ngBreast Cancer death reduced 60%
Preeclampsia RCT
50 ng COVID-19
T1 Diabetes
Fertility
Psoriasis
Infections Review
Infection after surgery
40 ng Breast Cancer 65% lower risk
Depression
ACL recovery
Hypertension
Asthma?
30 ng Rickets

* Evolution of experiments with patients, often also need co-factors


VitaminDWiki – Optimum category contains

The RDA is barely enough for the bones to survive.
   Need an optimal level for the body to thrive

99 items in Optimum Vitamin D category

Example pages


VitaminDWiki - Endocrine Society recommends for the healthy: no Vitamin D tests, just RDA (many object) - July 2024


Table from Holick Oct 2024
Image

Attached files

ID Name Comment Uploaded Size Downloads
21991 Vit D level vs health problem GRH.webp admin 19 Nov, 2024 114.13 Kb 293
21972 Endo recommendations.webp admin 16 Nov, 2024 64.13 Kb 120
21971 Holick charts.webp admin 15 Nov, 2024 110.04 Kb 181
21969 consequences.webp admin 15 Nov, 2024 65.16 Kb 186
21968 Vit D level vs health problem.webp admin 15 Nov, 2024 57.46 Kb 201
21967 Hollick Oct 2024 PDF_CompressPdf.pdf admin 15 Nov, 2024 627.05 Kb 65