Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency
Nutrients 2024, 16, 1754. https:// doi.org/10.3390/nul6111754
Marco Occhiuto 1,+ , Jessica Pepe 1,+, Luciano Colangelo 1 , Marco Lucarelli 2 , Antonio Angeloni 2, Luciano Nieddu 3, Viviana De Martino 1 , Salvatore Minisola and Cristiana Cipriani1©
Background: We assessed the long-term (24 months) efficacy and safety of monthly calcifediol (0.266 mg) in the correction and maintenance of total 25(OH)D levels in postmenopausal women with basal values <30 ng/mL.
Methods: We initially enrolled 45 consecutive patients during the period September 2019-September 2020. After an initial visit, patients were instructed to return at 3, 6, 9, 12 and 24 months for measuring serum total 25(OH)D, ionised calcium, creatinine and isoenzyme of alkaline phosphatase (bALP). Here, we report only the per-protocol analysis, because the COVID-19 pandemic precluded adherence to the scheduled visits for some patients.
Results: The patients' mean age was 62.4 ± 9.0 years. Mean basal 25(OH)D levels were 20.5 ± 5.3 ng/mL. There was a continuous increase of mean 25(OH)D values (p for trend < 0.001). However, mean values at month 24 (36.7 ± 15.9) were not significantly different in respect to values at month 12 (41.2 ± 11.18). At 24 months, only 1 out 19 patients had a value <20 ng/mL. There was a significant decrease with time of mean values of bALP (p < 0.0216), with no significant changes between 12 and 24 months. No significant changes were observed as far as ionised calcium or creatinine were concerned.
Conclusions: The long-term administration of calcifediol maintains stable and sustained 25(OH)D concentrations, with no safety concerns.
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45+ VitaminDWiki pages have CALCIFEDIOL etc. in the title
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Items found: 46
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Extended-Release Calcifediol is useful for Hyperparathyroidism - Sept 2024 |
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09 Oct, 2024 |
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Cows gave more milk after pregnancy if given Calcidiol (semi-activated Vitamin D) – RCT March 2021 |
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03 Aug, 2024 |
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Calcifediol (semi-activated vitamin D, Calcidiol) – Oct 2023 |
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01 Aug, 2024 |
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1 year to respond to monthly Calcifediol – June 2024 |
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20 Jun, 2024 |
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Fast responses to Vitamin D – loading dose, nanoemulsion and Calcifediol – April 2023 |
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15 Apr, 2023 |
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Responses to 3600 IU Vitamin D or Calcifediol – Oct 2022 |
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05 Oct, 2022 |
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Calcidiol quickly raises vitamin D level in pigs, but does not appear to provide any benefits – Aug 2022 |
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02 Sep, 2022 |
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Calcidiol (bacterial fermentation-derived vitamin D) OK with pigs (perhaps lower cost) - Aug 2022 |
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13 Aug, 2022 |
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Calcifediol (semi-activated Vitamin D) might treat Respiratory Diseases such as COVID - July 2022 |
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19 Jul, 2022 |
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Calcifediol (Calcidiol, semiactivated Vitamin D) - many studies |
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29 Jun, 2022 |
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Calcidiol |
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17 May, 2022 |
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COVID test positive 2X less likely if high vitamin D, Calcifediol looking good, etc. – Dec 31, 2021 |
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01 Jan, 2022 |
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Large dose of calcifediol or vitamin D up to 15 days before COVID hospitalization reduced death rates (1.5X, 1.3X) – Dec 2021 |
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04 Dec, 2021 |
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Calcifediol (Calcidiol) is far less cost-effective and available than Vitamin D – RCT June 2021 |
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04 Sep, 2021 |
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High-fat diet reduces CYP2R1 gene needed to make semi-activated vitamin D (mice) – Aug 2021 |
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28 Aug, 2021 |
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Calcidiol (Calcifediol, ampli-D) approved as food supplement by EFSA – (10 micrograms per day) – July 2021 |
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13 Jul, 2021 |
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7X less likely to go to ICU if COVID-19 ward gave calcifediol (semi-activated Vitamin D) – July 2021 |
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08 Jul, 2021 |
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Calcidiol increased blood levels of Vitamin D in one month (dogs) – Feb 2021 |
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10 Jun, 2021 |
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Calcifediol is superior to cholecalciferol (it mainly acts faster) – RCT June 2021 |
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10 Jun, 2021 |
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Need 3X more Vitamin D (or take semi-activated vitamin D) if have poor gut – small RCT May 2021 |
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26 May, 2021 |
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5X less likely to enter ICU with COVID-19 if get Calcifediol (semi-activated vitamin D) - RCT Feb 19, 2021 |
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13 Feb, 2021 |
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Response to weekly Calcifediol in 4 months - RCT Aug 2022 |
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03 Feb, 2021 |
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MATH plus protocol for COVID-19 includes Calcifediol or Vitamin D - Jan 2021 |
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26 Jan, 2021 |
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Weekly response to semi-activated vitamin D slightly better than standard – RCT Nov 2019 |
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21 Jan, 2021 |
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COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT Aug 29, 2020 |
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22 Nov, 2020 |
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Semi-activated Vitamin D given weekly (used by Spanish COVID-19 trial) – US patent application Sept 2020 |
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23 Sep, 2020 |
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Obesity cut semi-activation of Vitamin D in half (mice) – Jan 2019 |
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17 Jun, 2019 |
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Calcifediol (Calcidiol) might be a better form of Vitamin D for some people – May 2019 |
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09 May, 2019 |
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Calcifediol (25(OH)D3) may be 4 X better than Vitamin D for fortification – Aug 2018 |
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29 Jan, 2019 |
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Osteoporosis treatment by semi-activated (nutritional) Vitamin D – Sept 2018 |
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13 Jul, 2018 |
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Oral calcidiol is a good form of vitamin D supplementation – Aug 2017 |
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22 Dec, 2017 |
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Semi-activated vitamin D (HyD3) successfully being used in human trials – RCT Sept 2017 |
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22 Sep, 2017 |
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Poorly functioning livers do not process vitamin D (Calcidiol is needed) – Sept 2014 |
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27 May, 2017 |
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Liver transplant needs Vitamin D (actually semi-activated, not regular) – May 2017 |
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27 May, 2017 |
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Calcidiol may be 5X more effective than Vitamin D3 – June 2012 |
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25 Jan, 2017 |
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Vitamin D3 becomes Calcidiol which becomes Calcitriol |
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25 Jan, 2017 |
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Pigs have about 2X less variation in response to calcidiol as humans do to vitamin D – 2015 |
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07 Dec, 2015 |
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Nano-encapsulated of Vitamin D3, Calcidiol, calcitriol look promising, esp time release – Dec 2012 |
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03 Oct, 2015 |
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Vitamin D and calcidiol are not hormones, but calcitriol is a hormone – Aug 2014 |
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26 Jul, 2015 |
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Vitamin D can be converted into calcifediol by microbes – May 2015 |
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23 May, 2015 |
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Modified release active Vitamin D (calcifediol ) for those with poor Kidney function (USD 10,000 per year) – April 2015 |
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17 Apr, 2015 |
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Patent for combination of vitamin D3 and calcifediol– Sept 2009 |
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10 Sep, 2014 |
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Hepatitis C drug is extremely expensive, why not try Calcidiol (semi-processed vitamin D) - May 2014 |
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07 May, 2014 |
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25(OH)D (Calcidiol) in animal-based food adds about 80 IU of equivalent daily vitamin D – March 2014 |
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18 Mar, 2014 |
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130% more piglets after giving gilt Calcidiol, a form of vitamin D – Nov 2012 |
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21 Aug, 2013 |
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How much calcidiol or calcitriol is needed to slow aging in mice – 2009 |
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02 Jul, 2010 |
VitaminDWiki – Calcidiol category contains:
| 48 |
items in Calcidiol category
Calcidiol = Calcifediol = 25-hydroxyvitamin D3 = 25(OH)D = semi-activated Vitamin D
See also