Serum 25-hydroxyvitamin D3 levels and poor sleep quality in a Japanese population: the DOSANCO Health Study.
Sleep Med. 2019 Feb 22;57:135-140. doi: 10.1016/j.sleep.2019.01.046
Nakamura K1, Hui SP2, Ukawa S3, Okada E4, Nakagawa T5, Okabe H2, Chen Z2, Miura Y6, Chiba H7, Tamakoshi A8.
20% of Japanese adults are unsatisfied with their sleep
32% of participants located at42 degrees North Latitude were unsatisfied with their sleep
| Vitamin D ng/mL | Poor Sleep | Depression |
| 2-18 | 1.7 | 18% |
| 18-23 | 0.7 | 13% |
| 23-28 | 0.65 | 12% |
| 28-79 | 1.0 | 12% |
Sleep category starts with
A few items in SLEEP category
- Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018
- Sleep disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
- Sleep, Dr. Gominak and Vitamin D - several studies
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Vitamin D for better sleep video - Dec 2021
- 5X increase in sleep problems in a decade in US Veterans
- Sleep Apnea and Vitamin D - many studies
- Melatonin and Vitamin D - many studies does much more than improve sleep
- Sleep less than 6 hours: 4X more-likely in men having less than 20 ng of Vitamin D – June 2021
- Poor sleep if low Vitamin D, Magnesium, or Vitamin B6 (NHANES) – June 2019
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – meta-analysis Oct 2018
- Chinese meta-analysis is the same as this Japanese study
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- Sleep disorders and Autism, TB, etc. (all have low vitamin D) – March 2018
- Vitamin D improves sleep and reduces pain – review of studies July 2017
- Sleep Apnea patients – 98 percent had low vitamin D – Feb 2016
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
Sleep is aided by Vitamin D + Vitamin Bs
Sleep is also aided by Omega-3
- Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018
- Omega-3 greatly reduced sleep deprivation problems in rats – June 2018
- Obstructive Sleep Apnea reduced by Omega-3 – June 2016
Download the PDF from Sci-Hub via VitaminDWiki
OBJECTIVE: The present cross-sectional study investigated the relationship between serum 25-hydroxyvitamin D3 (25[OH]D3) levels and the presence of poor sleep quality in a community-based Japanese adult population.
METHODS:
Poor sleep quality, defined as poor subjective sleep quality and/or use of sleep medications, was assessed using a self-administered questionnaire. The prevalence of poor sleep quality was compared among 512 Japanese participants aged 35-79 years, based on serum 25(OH)D3 levels, which were determined using tandem mass spectrometry. A logistic regression model was used to calculate the odds ratios (ORs) for the presence of poor sleep quality in each group with the highest quartile of 25(OH)D3 serving as the reference group.
RESULTS:
Poor sleep quality was reported by 33.2% of the total study population. The prevalence of poor sleep quality was higher in the first quartile group (25[OH]D3: 2.08-18.13 ng/mL) than in the second, third and fourth quartile groups (18.14-23.07 ng/mL, 23.08-28.32 ng/mL, and 28.33-78.83 ng/mL, respectively). The ORs for poor sleep quality were 1.86 (95% confidence interval, 1.08-3.20) for the first quartile group, 0.73 (0.41-1.29) for the second quartile group, and 0.73 (0.42-1.27) for the third quartile group after adjusting for age, sex, and sociodemographic, lifestyle, physical and environmental factors, while the ORs were 1.68 (0.96-2.95), 0.69 (0.39-1.24), and 0.65 (0.37-1.15) after further adjustment for overall health status and depression status.
CONCLUSIONS: The first quartile group of serum 25(OH)D3 was associated with the presence of poor sleep quality.
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