The effect of vitamin D on clinical outcomes in tuberculosis
Egyptian Journal of Chest Diseases and Tuberculosis. online 30 Jan 2017, http://dx.doi.org/10.1016/j.ejcdt.2017.01.004
Aliasghar Farazia, , , , Farshideh Didgarb, Aghmorad Sarafrazc
If the dose size had varied with weight, skin color, Vitamin D levels, etc, we doubtlessly would have seen even more benefit
- Overview Tuberculosis and Vitamin D
- Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis May 2015
- TB conversion 10X less likely if have sufficient vitamin D – Dec 2011
Items in both categories TB and Intervention are listed here:
- Spinal TB surgery now includes Vitamin D as the standard of care (5,000 IU daily) – Sept 2024
- TB treatment helped by the addition of Vitamin D (100,000 IU bi-weekly) – RCT April 2024
- Tuberculosis not prevented by a tiny amount of vitamin D (equiv to 1,400 IU daily) – RCT May 2023
- Tuberculosis treatment helped a bit by a bit of Vitamin D - RCT Feb 2022
- TB not prevented by a small amount of Vitamin D (2,000 IU daily average, Mongolia) – RCT July 2020
- TB not treated by vitamin D given for only 2 months – RCT Sept 2017
- Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017
- Tuberculosis treatment greatly helped by injection of 200,000 IU of vitamin D – RCT April 2016
- Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
- Tuberculosis not treated by lots of vitamin D for 16 weeks – RCT Sept 2015
- Every TB patient benefited from 2 doses of 600,000 IU of vitamin D – RCT Jan 2013
- TB treatment helped with Vitamin D – RCT Sept 2012
- Probability of getting TB reduced 60 percent with just 800 IU of vitamin D – RCT Aug 2012
- Overview Tuberculosis and Vitamin D
- Evaluating the vitamin D evidence - Heaney Dec 2010
See also web
- Blacks born in Africa and moved to US had 27X higher rate of TB than people born in the US 2000-2009
Note: Many studies have found that first generation dark skinned peoples moving far from equator are very vitamin D deficient and are far more likely to get diseases associated with low vitamin D. TB is just one example
Download the PDF from VitaminDWiki
Introduction
Vitamin D enhances immune responses to tubercle bacillus. The aim of our study is to determine the improvements of clinical outcome in patients taking cholecalciferol as supplement accompany anti-tuberculosis treatment.
Materials and methods
In a placebo-controlled and double blinded clinical trial sixty patients with pulmonary tuberculosis from March 2014 to July 2015 in Markazi province of Iran were randomized to take either single dose of 450,000 International Units of cholecalciferol or placebo. Evaluation was carried out at one, two and three months later. The first outcome was reduction in TB score and the secondary outcome was smear conversion and improvement of quality of life.
Results
Mean calcidiol levels for the whole study population were 22.81 ± 10.76 ng/ml and there have been no associations between baseline calcidiol levels and sputum smear burden (P-value = 0.54). There was an association of TB severity score with lower levels of Vitamin D (P-value = 0.043). The Short Form (SF)-12 health survey scoring at enrolment in two arms did not differ significantly (P-value = 0.786). Two months’ later findings indicate that Vitamin D treatment had a positive effect on progressing health-related quality of life (P-value = 0.019) in each subscale of physical health score (P-value = 0.028) and mental health score (P-value = 0.025).
Conclusions
Our findings indicated that single dose cholecalciferol supplementation can lead to improving clinical outcome in tuberculous patients especially in those with calcidiol deficiency and improve the health-related quality of life of TB patients.