Latent tuberculosis infection,tuberculin skin test conversion and vitamin D status in contacts of tuberculosis patients: a cross-sectional and case-control study.
Alberto Arnedo-Pena, Jose V Juan-Cerdan, Angeles Romeu-Gracia, Daniel Garcia-Ferrer, Rita Holguin-Gomez, Jesus Iborra-Millet, Concepcion Herrero-Carot, Jesus Sanchis-Pinana, Juan Bellido-Blasco, Jose A Ferrero-Vega, Lourdes S Adsuara, Esther S Silvestre, Noemi M Ferrer and Vicenta R Bartual
BMC Infectious Diseases 2011, 11:349 doi:10.1186/1471-2334-11-349; Published: 15 December 2011
Background Deficient serum vitamin D levels have been associated with incidence of tuberculosis (TB), and latent tuberculosis infection (LTBI). However, to our knowledge, no studies on vitamin D status and tuberculin skin test (TST) conversion have been published to date. The aim of this study was to estimate the associations of serum 25-hydroxyvitamin D3 (25[OH]D) status with LTBI prevalence and TST conversion in contacts of active TB in Castellon (Spain).
Methods The study was designed in two phases: cross-sectional and case-control. From November 2009 to October 2010, contacts of 42 TB patients (36 pulmonary, and 6 extra-pulmonary) were studied in order to screen for TB. LTBI and TST conversion cases were defined following TST, clinical, analytic and radiographic examinations. Serum 25(OH)D levels were measured by electrochemiluminescence immunoassay (ECLIA) on a COBAS(R) 410 ROCHE(R) analyzer. Logistic regression models were used in the statistical analysis.
Results The study comprised 202 people with a participation rate of 60.1%.
Only 20.3% of the participants had a sufficient serum 25(OH)D ([greater than or equal to]30ng/ml) level.
In the cross-sectional phase, 50 participants had LTBI and no association between LTBI status and serum 25(OH)D was found.
After 2 months, 11 out of 93 negative LTBI participants, without primary prophylaxis, presented TST conversion with initial serum 25(OH)D levels:
b:12.5% (4/32):20-29 ng/ml, and
c:0%(0/25) [greater than or equal to]30ng/ml.
A sufficient serum 25(OH)D level was a protector against TST conversion
a: Odds Ratio (OR) =1.00; b: OR = 0.49 (95% confidence interval (CI) 0.07-2.66); and
c: OR = 0.10 (95% CI 0.00-0.76), trends p=0.019, adjusted for high exposure and sputum acid-fast bacilli positive index cases.
The mean of serum level 25(OH)D in TST conversion cases was lower than controls,17.5+/-5.6 ng/ml versus 25.9+/-13.7 ng/ml (p=0.041).
Conclusions The results suggest that sufficient serum 25(OH)D levels protect against TST conversion.
- Overview TB Vitamin D
- All items in TB and Vitamin D
Items in both VitaminDWiki categories of TB and Intervention are listed here:
- TB not treated by average daily 10,000 IU of vitamin D (previous RCTs disagree) – RCT Sept 2017
- Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017
- Tuberculosis treatment greatly helped by injection of 200,000 IU of vitamin D – RCT April 2016
- Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
- Tuberculosis not treated by lots of vitamin D for 16 weeks – RCT Sept 2015
- Every TB patient benefited from 2 doses of 600,000 IU of vitamin D – RCT Jan 2013
- TB treatment helped with Vitamin D – RCT Sept 2012
- Probability of getting TB reduced 60 percent with just 800 IU of vitamin D – RCT Aug 2012
- Overview Tuberculosis and Vitamin D
- Evaluating the vitamin D evidence - Heaney Dec 2010