Kidney Inflammation not reduced by 30 ng Vitamin D (many health problems need 50 ng) – Nov 2022

---

Effects of vitamin D on inflammatory state in patients with chronic kidney disease: a controversial issue

Ther Apher Dial . 2022 Nov 8. doi: 10.1111/1744-9987.13949
Liangbin Zhao 1 , Guoshuang Zhu 2 , Ling Wu 1 , Dengpiao Xie 1

Background: The anti-inflammatory effect of vitamin D in patients with chronic kidney disease (CKD) remains controversial. This study aimed to conduct a meta-analysis of randomized controlled trials to assess the anti-inflammatory effects of vitamin D in patients with CKD.

Methods: We searched Embase, Science Citation Index, Medline, Cochrane Central Register of Controlled Trials, and Clinical Trial Registries for randomized controlled trials that comparing vitamin D with control groups for inflammatory markers in patients with CKD. Subgroup analysis were performed based on treatment duration (short-term treatment, long-term treatment), type of patients (predialysis CKD, dialysis, kidney transplant), 25(OH)D levels (25(OH)D deficiency or normal 25(OH)D), methods of C-reactive protein (CRP) test (standard CRP test or high-sensitivity CRP (hs-CRP) test) RESULTS: 18 trials with 1834 patients were included in the present study. There was no significant differences between the vitamin D group and control group for CRP (WMD, -0.3mg/L; 95% CI, -0.81 to 0.22, p=0.26, I2 =62%), interleukin-6 (IL-6) (WMD, -1.07pg/mL; 95% CI, -2.44 to 0.30, p=0.12, I2 =52%), and tumor necrosis factor-α (TNF-α) (WMD, -0.00pg/mL; 95% CI, -0.36 to 0.35, p=0.99, I2 =0%) in patients with CKD. Subgroup analysis showed vitasmin D can improve hs-CRP, but not CRP. The rest of subgroups showed that no significant differences was observed between the vitamin D group and control group based on 25(OH)D levels, treatment duration, and predialysis CKD or dialysis patients.

Conclusion: This meta-analysis demonstrates that vitamin D supplementation does not have anti-inflammatory effects in CKD patients. Well-designed randomized controlled trials with large samples are required to confirm this conclusion. It is still needed to find an effective treatment for inflammatory state in CKD.

---

Vitamin D needed to TREAT Health problems 30 ng rickets, 150 ng MS

Vitamin D	Treats
150 ng	Multiple Sclerosis *
80 ng	Cluster Headache * Reduced office visits by 4X *
70 ng	Sleep *
60 ng	Breast Cancer death reduced 60% Preeclampsia RCT
50 ng	COVID-19 Fertility Psoriasis Infections Review Infection after surgery
40 ng	Breast Cancer 65% lower risk Depression ACL recovery Hypertension Asthma?
30 ng	Rickets

* Evolution of experiments with patients, often also need co-factors

• Click here for more information

---

VitaminDWiki - Overview Kidney and vitamin D contains

• FACT: The Kidneys are not the primary way to activate vitamin D; the tissues are
• FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
• FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
• FACT: There are many ongoing intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
• FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
• FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
• FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
• Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
    Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
  Nanoemulstion vitamin D (inside cheek, topically) gets activated Vitamin D to the cells without the need for healthy kidney, liver, or intestine
  Calcitriol - which bypasses the need for the kidney to activate vitamin D
    Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
      Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
• Category Kidney and Vitamin D contains 232 items

---

VitaminDWiki - Inflammation category contains

175 items total

Example studies

• Vitamin D reduces autoimmune, cardio, and metabolic Inflammation – Nov 2024
• Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
• COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
• Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020
• Vitamin D reduces inflammation in critically ill patients – Sept 2020
• Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
• How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
• CYTOKINE in VitaminDWiki 12 titles as of July 2023
• 17 pages in VitaminDWiki had REACTIVE or CRP in title as of July 2023
• Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014

---

VitaminDWiki - 5 studies in both categories Kidney and Inflammation

This list is automatically updated