Prostate Cancer – Vitamin D – CYP27B1 – CYP24 – June 2011

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Vitamin D metabolism and action in the prostate: Implications for health and disease.

Mol Cell Endocrinol. 2011 Jun 1.
Swami S, Krishnan AV, Feldman D.
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Prostate cancer (PCa) is the second most common cancer in men worldwide. Epidemiological, molecular, and cellular studies have implicated vitamin D deficiency as a risk factor for the development and/or progression of PCa. Studies using cell culture systems and animal models suggest that vitamin D acts to reduce the growth of PCa through regulation of cellular proliferation and differentiation. However, although preclinical studies provide a strong indication for anti-cancer activity, proof of therapeutic benefits in men is still lacking. The anti-proliferative and pro-differentiating properties of vitamin D have been attributed to calcitriol [1,25(OH)(2)D(3)], the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR). Metabolism of vitamin D in target tissues is mediated by two key enzymes: 1?-hydroxylase (CYP27B1), which catalyzes the synthesis of calcitriol from 25(OH)D and 24-hydroxylase (CYP24), which catalyzes the initial step in the conversion of calcitriol to less active metabolites. Many factors affect the balance of calcitriol synthesis and catabolism and several maneuvers, like combination therapy of calcitriol with other drugs, have been explored to treat PCa and reduce its risk. The current paper is an overview addressing some of the key factors that influence the biological actions of vitamin D and its metabolites in the treatment and/or prevention of PCa.

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VitaminDWiki - Overview Prostate Cancer and Vitamin D contains

All items in category Prostate Cancer and Vitamin D 103 items

Examples
Prostate cancer patients in Jamaica were 5X more likely to die of PC if low vitamin D - Sept 2022
Prostate Cancer – 300,000 annual deaths, low vitamin D is one of many factors – current status March 2015
No indication of association with Prostate Cancer and retinol, vitamin E or active vitamin D – Nov 2012
Can take 40,000 IU of vitamin D daily before prostate cancer surgery – RCT March 2013
The sun appears better at reducing incidence of some cancers than vitamin D – Dec 2012
The Meta-analysis of Prostate Cancer

Vitamin D prevents/treats Prostate Cancer much better when there is not excess Calcium
Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018 prevention
Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015 treatment
7X increase in stage IV Prostate Cancer survival when vitamin D greater than 32 ng – May 2013
Never too late to have vitamin D - loading dose is great before Prostate Surgery

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See also VitaminDWiki

• Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015
• Overview Cancer and vitamin D
• Unsure of association of vitamin D and prostate Cancer - 2011 looking at same genes
• 63 items in CYP27B1 category