Atrial Fibrillation DECREASED by Vitamin D or Magnesium
Atrial Fibrillation INCREASED by Calcium or high-dose Omega-3
- 23+ VitaminDWiki pages with AFIB or FIBRILLATION in title
- 5% less likely to get AFIB if 10 ng higher Vitamin D - Maga-analysis Sept 2023
- 23% less likely for seniors to get AFIB if 10 ng higher Vitamin D – 13 studies – 2019
- Risk of Atrial Fibrillation Decreases if Vitamin D or Magnesium Increase - GRH Sept 2022
- The Pathogenesis of Cardiac Arrhythmias in Vitamin D Deficiency - May 2022
- High-Dose Omega-3 increases risk of atrial fibrillation - meta-analysis July 2021
- Cardiovascular category in VitaminDWiki
- Cardiovascular and Magnesium
17 studies - Cardiovascular and Calcium
15 studies - CLIFF NOTES FOR ATRIAL FIBRILLATION - May 2024
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23+ VitaminDWiki pages with AFIB or FIBRILLATION in title
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Items found: 24- - - - See also 4 Cardiovascular diseases are associated with little vitamin D getting to cells – May 2023
5% less likely to get AFIB if 10 ng higher Vitamin D - Maga-analysis Sept 2023
Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studies
Front Nutr. 2023 Sep 21:10:1246359. doi: 10.3389/fnut.2023.1246359
Xiaoli Ding 1, Jiying Lai 2, Hehui Zhang 2, Zongwen Guo 2Background: Since the association of vitamin D with atrial fibrillation (AF) risk is still unclear, we conducted this updated meta-analysis of prospective studies to identify the relationship between vitamin D or vitamin D supplementation and AF in the general population.
Methods: We conducted a comprehensive search of multiple databases up to May 2023 for studies reporting vitamin D and AF. The hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled by a random-effects model.
Results: A total of seven studies were included in this meta-analysis. Vitamin D deficiency (<20 ng/ml) was associated with increased AF incidence (HR: 1.12, 95% CI: 1.005-1.25). The HR was not significant with vitamin D insufficiency (20-30 ng/ml; HR: 1.09, 95% CI: 0.98-1.21). Each 10 ng/ml increase in serum vitamin D was associated with a significantly decreased AF incidence (HR: 0.95, 95% CI: 0.93-0.97). Two studies reported the effect of vitamin D supplements on AF incidence but reached inconsistent results.
Conclusions: Vitamin D deficiency or insufficiency was associated with an increased risk of AF in the general population. The role of vitamin D supplementation in AF prevention needs further investigation.
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23% less likely for seniors to get AFIB if 10 ng higher Vitamin D – 13 studies – 2019
The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies
Nutrition Journal volume 18, Article number: 73 (2019)
Xiao Liu, Wei Wang, Zhaochong Tan, Xin Zhu, Menglu Liu, Rong Wan & Kui HongBackground
The relationship between serum vitamin D and atrial fibrillation (AF) or postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass graft (CABG) is still debated. It is also unclear whether there is a dose-response relationship between circulating vitamin D and the risk of AF or POAF.Methods
The Cochrane Library, PubMed, and Embase databases were searched for relevant studies. We used a “one-stage approach” with a restricted cubic spline model to summarize the dose-specific relationships between serum vitamin D and AF. Relative risk (RR) was used to measure the effects in this meta-analysis.Results
In total, 13 studies were included with a total of 6519 cases of AF among 74,885 participants. Vitamin D deficiency (< 20 ng/ml) was associated with increased risks of AF (RR: 1.23, 95% CI: 1.05–1.43). In the dose-response analysis, the summary RR for a 10 ng/ml increased in vitamin D was 0.88 (95% CI: 0.78–0.98) and there was no evidence of a non-linear association, P non-linearity = 0.86.
In the age subgroup, high vitamin D (per 10 ng/ml increase) reduced the risk of AF in the- older group (> 65 years) (RR = 0.68, 95% CI = 0.52–0.89)
- but not among young individuals (< 65 years) (RR = 0.87, 95% CI = 0.72–1.06).
In addition, a strong association was found between a 10 ng/ml increased in vitamin D and POAF incident in the patient after CABG (RR: 0.44, 95% CI: 0.24–0.82).
Conclusion
Our dose-response meta-analysis suggested serum vitamin D deficiency was associated with an increased risk of AF in the general population and POAF in patients after CABG. Further studies are needed to explore the age difference in the association between serum vitamin D level and the risk of AF and whether vitamin D supplements will prevent AF.
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Risk of Atrial Fibrillation Decreases if Vitamin D or Magnesium Increase - GRH Sept 2022
Risk of Atrial Fibrillation Decreases as Vitamin D and Magnesium Levels Increase - GRH Sept 2022
Includes the following graphs
The Pathogenesis of Cardiac Arrhythmias in Vitamin D Deficiency - May 2022
Biomedicines 2022, 10(6), 1239; https://doi.org/10.3390/biomedicines10061239
by Maria Barsan 1ORCID,Anca Monica Brata 2,*,Abdulrahman Ismaiel 3ORCID,Dinu Iuliu Dumitrascu 4,Andrei-Vlad Badulescu 5ORCID,Traian Adrian Duse 5ORCID,Stefana Dascalescu 5,Stefan Lucian Popa 3ORCID,Simona Grad 3,Lucian Muresan 6ORCID,Carmen Maria Maerescu 7,Gabriel Cismaru 8 andVlad Dumitru Brata 5ORCIDThe global prevalence of vitamin D deficiency is more than 20%, and the main causes include insufficient intake, reduced absorption, abnormal metabolism, or resistance to its effects. The levels of serum vitamin D appear to influence cardiovascular risk, and the mechanism involved is linked to the transient outward current and the ultrarapid delayed rectifier K+ current densities, activated through the nuclear vitamin D receptor and Akt pathway. A significant number of studies have correlated vitamin D deficiency with an increased risk of developing cardiac arrhythmias and sudden cardiac death. For this reason, the purpose of this review is to analyze the relation between vitamin D deficiency and the pathogenesis of cardiac arrhythmias. Atrial fibrillation, increased QT interval, and QT dispersion were the most common findings associated with vitamin D deficiency. Due to the heterogeneity among existing studies, further research is necessary to confirm the existing data and to analyze its relationship with other types of arrhythmias
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High-Dose Omega-3 increases risk of atrial fibrillation - meta-analysis July 2021
Omega-3 fatty acids supplementation and risk of atrial fibrillation: an updated meta-analysis of randomized controlled trials
European Heart Journal - Cardiovascular Pharmacotherapy, Vol 7, Issue 4, July 2021, Pages e69–e70, https://doi.org/10.1093/ehjcvp/pvab008
Marco Lombardi, Salvatore Carbone, Marco Giuseppe Del Buono, Juan Guido Chiabrando, Giovanni Maria Vescovo, Massimiliano Camilli, Rocco Antonio Montone, Rocco Vergallo, Antonio Abbate, Giuseppe Biondi-Zoccai ...
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Chart is from Examine
Editorial: High-Dose Omega-3 Fatty Acids and Atrial Fibrillation
Omega-3 Fatty Acids and Atrial Fibrillation - Editorial
AMA. 2021;325(11):1063. doi:10.1001/jama.2021.2909 FREE PDF
Gregory Curfman, MD1In 2019, the global market for omega-3 fatty acids reached $4.1 billion, and it is expected to double by 2025.1 These impressive expenditures reflect the worldwide popularity of these products and the belief by many that omega-3 fatty acids are beneficial to their health. Although the health benefits of these products remain questionable, it is important for consumers who take them to understand their potential risks. In this issue of JAMA, the VITAL Rhythm Study2 examined the risk of atrial fibrillation (AF), the most common cardiac arrhythmia, with intake of omega-3 fatty acids.
In the past 2 years, 4 randomized clinical trials have provided data on the risk of AF with omega-3 fatty acid intake. In the STRENGTH trial,3 13 078 high-risk patients with cardiovascular disease were randomized to receive a high dose, 4 g/d, of a carboxylic acid formulation of omega-3 fatty acids (a combination of eicosapentaenoic acid EPA and docosahexaenoic acid DHA) or corn oil. After a median of 42 months, there was no significant difference between the 2 randomized groups in the primary composite cardiovascular end point, but there was an increase in risk of developing AF in the omega-3 fatty acids group compared with the corn oil group (2.2% vs 1.3%; hazard ratio, 1.69; 95% CI, 1.29-2.21; P < .001).
In the REDUCE-IT trial,4 8179 participants were randomized to a high dose (4 g/d, as in STRENGTH) of an omega-3 fatty acid preparation consisting of purified EPA (icosapent ethyl) or mineral oil. After a median follow-up of 4.9 years, icosapent ethyl resulted in a 25% relative reduction in the primary composite cardiovascular end point compared with mineral oil. As in STRENGTH, there was a significant increase in risk of AF with omega-3 fatty acids compared with mineral oil (5.3% vs 3.9%; P = .003).
In a third clinical trial, OMEMI,5 1027 older patients who had had a recent myocardial infarction were randomized to receive an intermediate dose, 1.8 g/d, of omega-3 fatty acids (a combination of EPA and DHA) or corn oil. After 2 years, there was no significant difference between the 2 groups in the primary composite cardiovascular end point, but 7.2% of the omega-3 fatty acids group vs 4.0% of the corn oil group developed AF (hazard ratio, 1.84; 95% CI, 0.98-3.45; P = .06).
In the VITAL Rhythm Study,2 published in this issue of JAMA, 12 542 participants were randomized to receive a standard dose of omega-3 fatty acids, 840 mg/d (a combination of EPA and DHA) and 12 557 to receive placebo. After a median of 5.3 years, the incidence of AF was 7.2 per 1000 person-years in those taking omega-3 fatty acids vs 6.6 per 1000 person-years in those taking placebo (hazard ratio, 1.09; 95% CI, 0.96-1.24; P = .19).
Considered together, the data from the 4 trials suggest, but do not prove, that there may be a dose-related risk of AF with omega-3 fatty acid intake. At a dose of 4.0 g/d, there was a highly statistically significant increase in risk (nearly a doubling). With an intermediate dose of 1.8 g/d, the increase in risk (hazard ratio, 1.84) did not achieve statistical significance, and with a standard daily dose of 840 mg/d, there was no apparent increase in risk (although the data were consistent with as much as a 24% increase in risk). Patients who choose to take omega-3 fatty acids, especially in high doses, should be informed of the risk of AF and followed up for the possible development of this common and potentially hazardous arrhythmia.
Cardiovascular category in VitaminDWiki
Starts with
530 items In Cardiovascular category Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022
- Overview Cardiovascular and vitamin D
- Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
- Coronary Artery Disease and Vitamin D - many studies 18+
- Cardiovascular problems reduced by Omega-3 - many studies 34+
- Arteries and Atherosclerosis and Vitamin D - many studies 71+
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
- Statins and Vitamin D - many studies 25+
- Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
Cholesterol, Statins- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and Vitamin D - many studies statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
Cardiovascular and Magnesium
17 studies - More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Nitric oxide increased by UVA, Vitamin D, Magnesium, etc,
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies
- Signs of low Magnesium (heart problems in this case) – Jan 2018
- Ablation does not reduce atrial fibrillation (CABANA study) but Magnesium does – June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Heart problems in obese increase if deficient in BOTH Vitamin D and Magnesium – Aug 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Atrial Fibrillation - remineralize your heart - Aug 2015
- Magnesium Suppresses Formation of Clogged Arteries - May 2014
- Off Topic: EDTA similar reduction in heart attack as Vitamin C, aspirin and Mg – RCT March 2013
- Death from Coronary Heart Disease related to low Magnesium intake – March 2013
- Magnesium prevents cardiovascular events – Meta-analysis March 2013
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
Cardiovascular and Calcium
15 studies - Should not add rock Calcium to Vitamin D (after 20 year followup: 6% increase in heart problems – no surprise) – RCT May 2024
- Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019
- Less than 900 IU of Vitamin D and Calcium do not cause cardiovascular problems – Dec 2016
- 800 IU of vitamin D is not enough to help Cardiovascular Disease (found again) – Oct 2016
- Calcium supplementation associated with 3.9X increase risk of atrial fibrillation – June 2015
- Adding Calcium does NOT cause cardiovascular problems (reverses their meta-analysis) – Dec 2014
- Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
- More than 400 mg of Calcium supplements caused cardiovascular deaths in men - Feb 2013
- Stiff arteries in seniors associated with low vitamin D levels – July 2012
- Aortic Calcification 85 percent more likely if vitamin D level lower than 29 ng – June 2012
- More than 800 mg of Calcium increases Cardiovascular events by 85 percent– Nov 2011
- Is excess calcium harmful to health - 2010
- Review of Calcium – Vitamin D - Cardiovascular Disease – June 2011
- Calcium without vitamin D increased heart risk by 30 percent - Jan 2011
- Heart attacks increased by 30% in those taking 500 mg of Calcium without vitamin D – July 2010
CLIFF NOTES FOR ATRIAL FIBRILLATION - May 2024
Yoho substack
lots on Magnesium. He has another substack post just on Magnesium
There have been
192845 visits to this page
Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies179528 visitors, last modified 15 Aug, 2024, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 20349 AFIB Meta_CompressPdf.pdf admin 11 Nov, 2023 279.12 Kb 111 18387 Vit D afib GRH.jpg admin 07 Sep, 2022 42.37 Kb 1366 18386 Mg afib GRH.jpg admin 07 Sep, 2022 38.21 Kb 1481 18385 Afib 2022.pdf admin 07 Sep, 2022 308.98 Kb 398 17328 RR AF.jpg admin 04 Apr, 2022 47.36 Kb 227 17327 AF 2019.pdf admin 04 Apr, 2022 1.26 Mb 381 16275 Omega-3 afib.jpg admin 23 Sep, 2021 27.41 Kb 1525 16274 Omega-3 atrial fib meta.pdf admin 23 Sep, 2021 216.07 Kb 434
- Cardiovascular and Calcium