Vitamin D and outcomes in adult critically ill patients. A systematic review and meta-analysis of randomized trials.
J Crit Care. 2016 Nov 9;38:109-114. doi: 10.1016/j.jcrc.2016.10.029. [Epub ahead of print]
Putzu A1, Belletti A2, Cassina T3, Clivio S4, Monti G5, Zangrillo A6, Landoni G7.
- Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015 Dr. Matthews
- ICU death 2X more likely if low vitamin D (sensitivity and selectivity chart) – May 2015
- Trauma and surgery category listing has
352 items along with related searches - Dr. Grant on vitamin D and mortality in VitaminDWiki
- Bio-available Vitamin D following mega-doses (up to 500,000 IU) – Clinical trial due 2018
- 5 days of 100,000 IU of Vitamin D increased hemoglobin in critical illness – RCT April 2015
- Overview Loading of vitamin D
In both Intervention AND Trauma/surgery categories
- Spinal TB surgery now includes Vitamin D as the standard of care (5,000 IU daily) – Sept 2024
- Sepsis (with mechanical ventilation) treated by 5days of 50,000 IU of Vitamin D – RCT May 2024
- Half as much AFIB after bypass if 600,000 IU of vitamin D before surgery – RCT April 2022
- Half as many problems if take Vitamin D (300,000 IU) before thyroidectomy – RCT Jan 2021
- Those getting an injection of 300,000 IU Vitamin D got out of the ICU a week sooner – RCT Dec 2020
- Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020
- Better Surgical outcomes if preceded by Vitamin D loading dose – Oct 2018
- Knee replacement not helped by 2,000 IU of vitamin D (both too late and too little) – RCT July 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018
- Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT July 2017
- ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week - April 2017
- Vitamin D and Glutamine reduced Trauma Center deaths by half – Matthews March 2017
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- 18 fewer hospital days if given 500,000 IU of vitamin D while ventilated in ICU – RCT June 2016
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012
- Sepsis is both prevented and treated by Vitamin D - many studies
Items in both categories Mortality and Trauma-Surgery are listed here:
- 3X reduced mortality in one metabolic cluster of ICU patients by high-dose Vitamin D – Nov 2024
- 4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
- Poor Receptor predicts sepsis death (restricts Vitamin D from getting to cells) – Aug 2021
- Cardiac Surgery with low vitamin D increased delirium 1.4X, mortality 1.5X – May 2020
- Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT July 2017
- Low Vitamin D when entering ICU is deadly (acute kidney injury in this case) – Aug 2017
- Increased Hospital, Sepsis deaths if low vitamin D – March 2014
- Vitamin D and Glutamine reduced Trauma Center deaths by half – Matthews March 2017
- Half of Swiss emergency patients had low vitamin D: length of stay, mortality, etc. – May 2016
- Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
- ICU patients 30 % less likely to die if have enough vitamin D – meta-analysis Nov 2016
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- Radio frequency ablation survival doubled with even modest levels of vitamin D – Feb 2016
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- Risk of death within 90 days of ICU decreased by 16 percent for 1 nanogram extra vitamin D – June 2014
- ICU survival increased with vitamin D single 540K IU loading dose - JAMA Sept 2014
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- Hospital or ICU death about twice as likely if low vitamin D – March 2014
- 3X more likely to die within 3 months of being in ICU for 2 days if less than 20 ng vitamin D – Sept 2013
- Chance of dying within 1 month of entering hospital is 45 percent higher if low vitamin D – July 2013
- More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013
- Off topic: Use of ICU in month before death has increased to almost 30 pcnt – Feb 2013
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
- Critically ill 70 percent more likely to die if vitamin D less than 15ng – Jan 2011
PURPOSE:
Low vitamin D blood levels are associated with high mortality in critically ill patients. There is controversy about vitamin D supplementation in this population. The objective of this meta-analysis was to evaluate if vitamin D administration reduces mortality in critically ill patients.MATERIALS AND METHODS:
Online databases were searched up to September 1st, 2016 for randomized placebo-controlled trials on the use of vitamin D in adult patients with critical illness. The primary end point was mortality among trials with low risk of bias. The secondary end points were length of hospital stay, length of intensive care unit stay, length of mechanical ventilation, and adverse events.RESULTS:
Seven studies published between 2011 and 2016, for a total of 716 patients, were included in the analysis. Vitamin D administration was associated with significantly lower mortality compared with placebo (101/320 [32%] in the vitamin D group vs 123/307 [40%] in the placebo group; odds ratio, 0.70 [95% confidence interval, 0.50 to 0.98]; P=.04; I2=0%). No differences in adverse events and other secondary end points were found.CONCLUSIONS:
In critically ill patients, vitamin D administration might be associated with a reduction in mortality without significant adverse events. A large multicenter randomized trial should conclusively confirm these findings.PMID: 27883968 DOI: 10.1016/j.jcrc.2016.10.029
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