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Perhaps higher risk of fracture if low BMD plus low vitamin D – July 2022

Diagnosis of Low Bone Mass Density: Serological versus Radiological Methods

Int J Gen Med . 2022 Jul 1;15:5937-5945. doi: 10.2147/IJGM.S357417. eCollection 2022.
Osama A Shaikhomar 1, Abdelghnay H Abdelghnay 2 3, Haitham M H Qutob 4

Context: Bone remodeling comprises balanced coupling of bone formation and resorption, and low bone mineral density (BMD) demonstrates high rates of bone resorption. Osteoporosis is a chronic asymptomatic disease with fragile bones and impending risk of fractures mediated by minor trauma. Whereas bone mineralization and integrity are determined by calcium and vitamin D, specific serum markers such as bone specific alkaline phosphatase (ALP) and osteocalcin (OC) play a vital role in bone formation.

Materials and methods: Serum calcium, vitamin D, ALP, and OC levels were measured in 2,145 Saudi students aged 18-22 years at Umm Al-Qura University. The BMD was measured by dual-energy X-ray absorptiometry (DEXA), and the findings were statistically evaluated. The following statistics were utilized in the analysis: the SPSS software was used to record, tabulate, and statistically evaluate the results.

Results: Low BMD cases accounted for 27.46% of all cases investigated, with considerably higher serum calcium, bone-specific ALP, and OC levels compared to control cases, but significantly lower serum vitamin D levels. In low BMD instances, there was no association between serum markers and DEXA findings.

Conclusion: Serum indicators by themselves may be useful for screening and predicting patients at risk of osteoporosis, as well as assessing treatment response. The combination of serum markers and DEXA measures is more effective in detecting low BMD.
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Although the high serum levels of bone formation markers indicate newly-formed bones, those bones were found to be less mineralized which might negatively alter the bone microarchitecture and strength and predispose to the risk of fracture. 38,40
Therefore, serum markers might not be used for the diagnosis of low BMD. Instead, they may be used for prediction of people at risk of developing fractures, especially in postmenopausal women and for evaluation of the response to osteoporosis therapy. 28,29

VitaminDWiki - Overview Osteoporosis and vitamin D contains

  • FACT: Bones need Calcium (this has been known for a very long time)
  • FACT: Vitamin D improves Calcium bioavailability (3X ?)
  • FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
  • FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
  • FACT: Vitamin D supplements are very low cost
  • FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
  • FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
  • FACT: Co-factors help build bones.
  • FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
  • It appears that to TREAT Osteoporosis:
  •        Calcium OR vitamin D is ok
  •        Calcium + vitamin D is good
  •        Calcium + vitamin D + other co-factors is great
  •        Low-cost Vitamin D Receptor activators sometimes may be helpful
  • CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
  • Category Osteoporosis has 221 items
  • Category Bone Health has 314 items

Note: Osteoporosis causes bones to become fragile and prone to fracture
  Osteoarthritis is a disease where damage occurs to the joints at the end of the bones

VitaminDWiki - Osteoporosis category contains

VitaminDWiki - Falls and Fractures category contains

Falls

Left hand column section as of Nov 2024

     Ankle (16+)
     Bone & Stress Fractures
     Bone Mineral Density (28+)
     Children (16+)
     Hip Fractures (68+)
     Vertigo (22+)

Fracture

VitaminDWiki pages with BONE MINERAL DENSITY OR BMD in title (26 as of July 2022)

This list is automatically updated

Items found: 29
Title Modified
Vitamin D during pregnancy increased child’s bone mineral density – meta-analysis April 2023 27 Apr, 2023
Bone Mineral Density and Vitamin D - many studies 13 Apr, 2023
Transgender associated with autism, low vitamin D, low BMD, etc. - many studies 05 Apr, 2023
Bone mineral density improvement by Vitamin D plus fluoride is augmented by laser acupuncture – RCT March 2023 22 Mar, 2023
Perhaps higher risk of fracture if low BMD plus low vitamin D – July 2022 08 Jul, 2022
Exercise improves bone strength (good), but not bone mineral density (can be measured) – RCT Oct 2021 08 Oct, 2021
Bone Mineral Density increased by Resveratrol (which activates the Vitamin D Receptor) – RCT Nov 2020 17 Feb, 2021
Low bone mineral density is inversely associated with both Vitamin D and Resistin (resistance to insulin) 15 Jan, 2021
Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 2019 07 Sep, 2019
Bone mineral density somewhat better with 3750 IU vs 600 IU Vitamin D (1 year, with Calcium) – RCT March 2017 10 Mar, 2017
Low bone mineral density of male children is associated with low BMD of parents – Oct 2016 18 Oct, 2016
Osteoporosis vitamin D workshop - but still test BMD first - Oct 2010 19 Jan, 2016
Bone strength (more accurate than BMD) is inversely associated with vitamin D level – May 2015 30 May, 2015
Long bone fracture – prediction by low vitamin D is better than low BMD – Sept 2014 16 May, 2015
Hypothesis: increased bone mineral density needs protein, Ca, Mg, Vitamin D and K 28 Oct, 2014
Increasing bone mineral density increases breast cancer by at least 2X – Aug 2012 26 Oct, 2014
600,000 IU intramuscular D3 helped BMD after pancreatic surgery – June 2010 24 Jan, 2014
BMD associated with free and bioavailable vitamin D – March 2011 06 Jan, 2014
Low vitamin D, not low BMD, associated with both breaking hip and upper body bone in a fall – Oct 2013 05 Nov, 2013
Acute Multiple Sclerosis relapse associated with low bone mineral density (low vitamin D) – Oct 2013 12 Oct, 2013
Vitamin K2 from natto improved bone mineral density – March 2011 11 Oct, 2013
Working other than dayshift reduces vitamin D levels and Bone Mineral Density and increases bone pain – Aug 2013 22 Aug, 2013
Low vitamin D associated with 5.5X increased risk of low bone mineral density – March 2013 22 Aug, 2013
Hypothesis: Not vitamin D deficient if have normal PTH and BMD – May 2013 01 Jun, 2013
Vitamin D did not increase BMD among some ballet dancers – March 2012 28 Mar, 2012
9 minutes a day of sun improved BMD Parkinsons disease patients – Jan 2011 01 Jun, 2011
Reduced vitamin D and BMD and Neurological Conditions – April 2011 05 May, 2011
BMD improved with 800 mg Calcium, 400 IU of vitamin D, and 100 ug of vitamin K – April 2011 04 Apr, 2011
Low BMD among teaching doctors in India - July 2010 09 Jul, 2010

Hip fracture in VitaminDWiki title (67 as of June 2022)

This list is automatcially updated

Items found: 72
Title Modified
Hip fractures 60% more likely in people who drank a lot of milk - Greger Feb 2024 14 Feb, 2024
Hip fracture risk was reduced by 4 times when Vitamin D was added to SERMS - Jan 2024 25 Jan, 2024
Risk of Hip fracture cut in half if Vitamin D was prescribed - Aug 2023 26 Aug, 2023
Hip fractures are predicted by 10 factors – low Vitamin D is the biggest – Aug 2023 11 Aug, 2023
Hip fractures greatly reduced by sunshine, vitamin D, and vitamin K – meta-analysis Sept 2012 23 Dec, 2022
Hip fractures requiring hospitalization cut in half by Vitamin K1 (100 mcg per day) – Sept 2022 17 Dec, 2022
More hip fractures if low vitamin D (2.1X in case-controlled studies) – meta-analysis May 2022 01 Jun, 2022
Less than 3 percent of hip fracture patients prescribed enough Vitamin D to make a difference (Malta in this case) – July 2021 26 Jul, 2021
Recommends vitamin D after hip fracture ( but not enough and no-bone building co-factors) – May 2021 21 May, 2021
Call to action: Vitamin D to prevent of treat hip fracture (50,000 weekly for 8 weeks, then bi-weekly) – Holick July 2020 11 Dec, 2020
Risk factors for death after hip fracture surgery – 7 of the 8 are associated with low vitamin D – Aug 2020 09 Aug, 2020
Guideline following hip fracture – 50000 IU vitamin D daily for 7 days – Jan 2013 07 Jun, 2020
3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020 07 Mar, 2020
Hip fractures not prevented by Vitamin D (800 IU daily or large quarterly or annual doses) – meta-analysis – Dec 2019 21 Dec, 2019
Hip fractures reduced 16 to 33 percent by any amount of Vitamin D and Calcium – Oct 2019 05 Nov, 2019
Hip fracture rate increases in winter (subtropical Australia too) – Aug 2019 10 Aug, 2019
Warning - High intake of Vitamin B12 and B6 found to increase risk of hip fracture by 47 percent - 2019 19 May, 2019
Following hip fracture 2,000 IU of vitamin D daily improved quality of life – Feb 2019 23 Mar, 2019
Hip fractures worse if both high PTH and low Vitamin D – Jan 2019 01 Feb, 2019
Hip fracture recovery best with home exercise plus Vitamin D – RCT Dec 2018 12 Dec, 2018
Death of older hip fracture patients at least 1.6X more likely if low vitamin D – May 2018 19 Nov, 2018
France wants to reduce hip fractures by drinking 10 glasses of milk daily – April 2018 01 Apr, 2018
Hip fractures rates have been increasing since 2012 – Feb 2018 12 Feb, 2018
Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017 20 Dec, 2017
Hip fracture risk reduced 6 percent for each daily dairy serving (more if full-fat dairy) – Oct 2017 28 Oct, 2017
France is planning to reduce hip fractures by dairy vitamin D fortification (plan will not work) – 2017 17 Oct, 2017
Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016 23 Aug, 2017
Most Hip fracture patients had low vitamin D and protein (needed for strong bones) – May 2017 18 May, 2017
1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017 19 Apr, 2017
Vitamin D loading dose after hip fracture surgery was great – RCT Aug 2016 06 Apr, 2017
Following a stroke, a hip fracture is 6X more likely if low vitamin D – July 2001 04 Mar, 2017
Gene makes Hip Fracture 2.5X more likely unless get more vitamin D - Aug 2015 12 Nov, 2016
Partial (proximal) hip fracture strongly associated with low Vitamin D – Aug 2016 08 Nov, 2016
24 years ago hip fractures were reduced 24 percent in a large trial using Vitamin D and Ca – Oct 2016 22 Oct, 2016
Kaiser working to decrease hip and other fractures – Nov 2011 22 Oct, 2016
Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015 25 Sep, 2016
Hip fracture risk increased 2.5X if problem with Vitamin D Receptor gene (GC) – March 2014 25 Sep, 2016
Hip fracture 50 percent more likely if low in both vitamin D and vitamin K1 – Dec 2015 26 Dec, 2015
Hip fracture 3X more likely if low vitamin D – Dec 2015 26 Dec, 2015
5X fewer hip fractures from Parkinson – Alzheimer – Stroke with enough sun – June 2011 17 Jul, 2015
7 X more likely to get hip fracture if have highest level of vitamin A – Jan 2003 31 May, 2015
Delirium 2.7 X more likely after hip fracture and low vitamin D – May 2015 27 May, 2015
Hip fractures reduced 30 percent with 800 IU of vitamin D – meta-analysis July 2012 16 Mar, 2015
Hip fracture outcome 5X more likely to be poor if low vitamin D – Jan 2015 16 Mar, 2015
Hip fracture rate varies with latitude (and thus vitamin D) in Sweden – Nov 2013 20 Feb, 2015
Hip Fracture – 5X more likely to have bad outcome if have less than 20 ng of vitamin D – Dec 2014 22 Jan, 2015
Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 09 Nov, 2014
Hip fracture – not getting enough vitamin D – 2013 28 May, 2014
Hip fractures reduced 2X to 6X with just 10 minutes of sunlight daily – RCT 2003-2010 04 Dec, 2013
Men with hip fracture were 1.6X more likely to have low vitamin D – Aug 2013 09 Nov, 2013
5X increase in hip fracture rates in 65 years - 1998 27 Aug, 2013
Hip fracture reduced 38 percent with Calcium and just 400 IU of vitamin D – RCT Feb 2013 17 Aug, 2013
20 percent fewer male hip fractures if more Magnesium in the water – July 2013 11 Jul, 2013
Half as many hip fractures if take Calcium, hormones, and a tiny amount of vitamin D – July 2013 26 Jun, 2013
Male Hip fracture 1.65X more likely if low vitamin D – May 2013 01 Jun, 2013
Vitamin D needed to prevent and treat hip fracture, but only 20 percent got any – May 2013 31 May, 2013
Having less than 25 ng of vitamin D was associated with severe hip fracture – March 2011 30 Jan, 2013
Hip fracture 19 percent less likely with just 4 ng higher level of vitamin D – Dec 2012 20 Dec, 2012
Hip fracture and vitamin D – Health ABC study – May 2012 28 Sep, 2012
2X to 3X higher hip fracture rate in Asia in past 30 years – Aug 2012 18 Aug, 2012
Cataract surgery resulted in 30 percent fewer hip fractures – July 2012 02 Aug, 2012
Hip fractures in India - editorial with recommendation - Sept 2010 06 Jul, 2012
Women with hip fractures very low on vitamins D3 and K – Mar 2011 06 Jul, 2012
Upper body bones fractured along with hip when extremely low on vitamin D – Sept 2010 24 Jun, 2012
30 percent less chance of dying after hip fracture if take vitamin D and other drugs – 2011 24 Jun, 2012
75 percent of hip fractures associated with vitamin D deficiency - Jan 2011 24 Jun, 2012
Vitamin D 2nd most recommended way to prevent next hip fracture – Nov 2010 23 Jun, 2012
Hip fractures worse if very low on vitamin D – Mar 2011 23 Jun, 2012
Hip fracture patients had only 16 ng of vitamin D – May 2011 23 Jun, 2012
Declining hip fracture rates in the United States – unknown reason – June 2010 23 Jun, 2012
Vitamin K1 reduced hip fracture but Vitamin K2 did not – Aug 2011 23 Jun, 2012
Calcium and vitamin D supplements after hip fracture reduced death rate by 25% – Feb 2011 19 Nov, 2011
Created by admin. Last Modification: Friday July 8, 2022 15:03:30 GMT-0000 by admin. (Version 6)
Perhaps higher risk of fracture if low BMD plus low vitamin D – July 2022        
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