- Low vitamin D status is associated with inflammatory response in older patients with cerebral small vessel disease
- GTP-4 description of cerebral small vessel disease (April 2023)
- See also web
- VitaminDWiki – Stroke category contains
- VutaminDWiki - Inflammation category:
- VitaminDWiki - Brain and Vitamin D - many studies 94 as of March 2023
- VitaminDWiki – CYP27B1 category contains
- VitaminDWiki -
14 studies in both categories Stroke and Cognitive
Low vitamin D status is associated with inflammatory response in older patients with cerebral small vessel disease
J Neuroimmunol . 2023 Apr 15;377:578057. doi: 10.1016/j.jneuroim.2023.578057
(behind a paywall), free access to citations
Manjunath Supriya 1, Rita Christopher 2, Puttachandra Prabhakar 1, Sadanandavalli Retnaswami Chandra 3Objectives: This study aimed to determine the association of the NF-κB inflammatory signaling pathway with vitamin D status in older cerebral small vessel disease (SVD) patients.
Methods: We measured serum 25(OH)D, pro-and anti-inflammatory cytokines, and mRNA levels of the vitamin D-activating enzyme, CYP27B1, as well as NF-kB, COX-2, the chemokine-CCL2, IL-1β, IL-6, TNF-α, TGF-β, and IL-10, in cerebral SVD patients aged ≥60 years presenting with vascular dementia and age and gender-matched healthy controls.
Results: Low vitamin D status (insufficiency: serum 25(OH)D 12-20 ng/ml; deficiency: ≤12 ng/ml) was more prevalent among patients compared to controls. The mRNA levels of NF-kB, COX-2, CCL2, IL-1β, and IL-6, and serum levels of pro-inflammatory cytokines (IL-1α, IL-1β, IL-6, and TNF-α) were significantly higher in cases compared to controls. There was a significant correlation between CYP27B1 and NF-kB, COX-2, CCL2, and IL-1β gene expression. Serum IL-1α, IL-1β, and IL-6 concentrations and the expression of CCL-2, NF-kB2, and NF-kB3 genes were higher in vitamin D-deficient subjects compared to vitamin D-sufficient subjects. There was a significant negative correlation between serum 25(OH)D and IL-1α, IL-6, and TNF-α, and a positive correlation between 25(OH)D and IL-10.
Conclusion: Low vitamin D is associated with an inflammatory response via NF-kB signaling, which could play a role in the etio-pathogenesis of SVD. Further large-scale studies are required to validate our findings.
GTP-4 description of cerebral small vessel disease (April 2023)
Cerebral small vessel disease (CSVD) is a term used to describe a group of conditions that affect the small blood vessels in the brain. These diseases can lead to damage in the brain's white matter, deep gray matter structures, and can cause cognitive decline, stroke, and other neurological disorders. CSVD is associated with aging and is more common in older adults, but it can also occur in younger individuals.
There are several types of cerebral small vessel disease, including:
- Cerebral amyloid angiopathy: A condition in which amyloid proteins build up in the walls of the brain's small blood vessels, causing them to become weak and prone to leakage or bleeding.
- Hypertensive arteriopathy: High blood pressure can damage the walls of small blood vessels in the brain, leading to narrowing or blockage of the vessels and reduced blood flow to the brain tissue.
- Lacunar stroke: A type of stroke caused by the blockage of small blood vessels in the brain, leading to the formation of small cavities or "lacunes" in the brain tissue.
Hereditary forms of small vessel disease: Some genetic mutations can lead to inherited forms of CSVD, such as CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) and CARASIL (Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy).
Symptoms of cerebral small vessel disease can vary depending on the type and severity of the condition, and may include cognitive decline, memory problems, difficulties with balance and coordination, mood changes, and stroke-like symptoms such as sudden weakness or numbness on one side of the body. Treatment usually focuses on managing risk factors, such as high blood pressure, diabetes, and high cholesterol, as well as addressing the symptoms and complications that arise from the disease.
See also web
- 25-Hydroxy vitamin D level is associated with total MRI burden of cerebral small vessel disease in ischemic stroke patients - 2019 - https://doi.org/10.1080/00207454.2018.1503182 - can probably get from xxx
- 3.3X more likely if low vitamin D
- Cerebral small vessel disease and vascular cognitive impairment: from diagnosis to management - April 2021 FREE PDF
VitaminDWiki – Stroke category contains
131 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D Overview Cardiovascular and vitamin DStroke more likely if low Vitamin D
- Stroke 74% less likely if high vitamin D (7,295 women 20-50 years old) – July 2017
- Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
- Ischemic stroke 17 X more likely if low vitamin D – April 2017
- Stroke is strongly associated with Calcification of cerebral arteries (perhaps low Vitamin D, Vitamin K, Mg…) – March 2018
- Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014
Post-Stroke worse if low Vitamin D
- Poor Acute Ischemic Stroke 4X more likely if low Vitamin D - Nov 2023
- Stroke risks increased if low Vitamin D: Death 3.6 X, recurrence 5.5 X – Meta-analysis Nov 2019
- Stroke outcome at 3 months was 3X worse if bad stroke and low vitamin D – Jan 2020
- Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019
- Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
- Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
- Stroke incidence not associated with low Vitamin D (but stroke outcome is) – Aug 2019
Post-Stroke better if add Vitamin D
- Post-stroke Vitamin D supplementation helped in 11 ways – May 2023
- Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
- Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
- Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016
- Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT June 2019
Post-Stroke better if Vitamin D actually gets to cells
- Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018
- Stroke rehabilitation (and prevention) requires Vitamin D actually getting to cells – March 2020
11 studies in both categories of Depression and Stroke This list is automatically updated
- Nerve cells and Vitamin D – many studies
- Water-soluble form of vitamins are needed for some health problems
- Post-stroke depression not reduced by 2,000 IU of vitamin D (not a surprise) – Nov 2021
- Depression is associated with stroke if low vitamin D or winter – Nov 2018
- Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
- Omega-3 and Vitamin D each treat many mental health problems - April 2018
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- No longer depressed, but risk of stroke is still 1.7X higher (did not consider low vitamin D) – May 2015
- ALL of the top 10 health problems of women are associated with low vitamin D
- Post stroke depression 9X more likely if low vitamin D – Dec 2014
- Stroke patients with low vitamin D were 10X more likely to become depressed – Aug 2014
VutaminDWiki - Inflammation category:
175 items total Example studies
- Vitamin D reduces autoimmune, cardio, and metabolic Inflammation – Nov 2024
- Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
- COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
- Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020
- Vitamin D reduces inflammation in critically ill patients – Sept 2020
- Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- CYTOKINE in VitaminDWiki 12 titles as of July 2023
- 17 pages in VitaminDWiki had REACTIVE or CRP in title as of July 2023
- Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014
VitaminDWiki - Brain and Vitamin D - many studies 94 as of March 2023
VitaminDWiki – CYP27B1 category contains
The CYP27B1 gene activates Vitamin D in the Kidney, Skin, Lungs, Brain, Eyes Breasts etc.
Poor CYP27B1 is assocated with COVID, Miscarriage, Lupus, Alz, Parkinson, MSA, RicketsCYtochrome P450 family 27 subfamily B member 1 = 25-Hydroxyvitamin D3 1-alpha-hydroxylase
63 items in CYP27B1 category 343 articles in the Genetics 530 articles in Vitamin D Receptor 178 articles in Vitamin D Binding Protein - CYP27B1 and other genes are less activated in seniors
- CYP27B causes many health problems – March 2020
- Every Parkinson’s brain had a poor CYP27B1 gene
What can be done if have a poor CYP27B1
- Larger doses of Vitamin D
- More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
- Additional sources: UV
- Increase Vitamin D metabolism: additional Magnesium, Omega-3
- All cytochrome P450 enzymes require Mg++ as a cofactor
- Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR
Vitamin D blood test misses CYP27B1 and other genes
VitaminDWiki -
14 studies in both categories Stroke and Cognitive This list is automatically updated
- Nerve cells and Vitamin D – many studies
- Inflammation of small blood vessels in the brain is associated with low vitamin D - April 2023
- Vitamin D also provides COVID Neuroprotection – April 2022
- Inhaling Vitamin D nanoemulsion through nose gets lots more to the brain (mice) – July 2020
- Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018
- More Cognitive Impairment after some types of stroke if low vitamin D - many studies
- Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018
- Omega-3 and Vitamin D each treat many mental health problems - April 2018
- Blacks with strokes having low Vitamin D were 3 times more likely to have cognitive impairment – Nov 2016
- Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
- Stroke results in 8 years of cognitive decline (vitamin D not mentioned) May 2015
- ALL of the top 10 health problems of women are associated with low vitamin D
- Fewer white spots in MRI brain scans if had more vitamin D – Jan 2014
- 5X fewer hip fractures from Parkinson – Alzheimer – Stroke with enough sun – June 2011
Inflammation of small blood vessels in the brain is associated with low vitamin D - April 2023Printer Friendly Follow this page for updates4979 visitors, last modified 04 Apr, 2023, This page is in the following categories (# of items in each category)