Vitamin D Changes Expression of DNA Repair Genes in the Patients with Multiple Sclerosis
Gene online 13 February 2021, https://doi.org/10.1016/j.gene.2021.145488
lRoyaAmirinejadaZeinabShirvani-FarsanibBaharNaghavi GargaricMohhamadAli SahraiandBahramMohammad SoltaniaMehrdadBehmanesha
Highlights
- A positive correlation between transcript level of MYH, MTH1, OGG1, ITPA with NRF2 mRNA level in PBMCs of MS patients.
- In silico analysis revealed putative AREs at OGG1, MYH, ITPA, and MTH1 promoter sequences that were considered as NRF2 consensus sequences in humans.
- Impact of VD on MS patients may be mediated through the improvement of DNA repair system efficiency.
Vitamin D has be used to succesfully treat Multiple Sclorosis for over 10 years.
This study identifies a possible mechanism
Over 20,000 people with Multiple Sclerosis use high-dose vitamin D to virually eliminate their symptoms
Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019
- Overview MS and vitamin D
- An opportunity - use Vitamin D to treat Multiple Sclerosis (has been used for 14 years) - Feb 2022
- Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis May 2018
- Multiple Sclerosis: 10 percent fewer relapses for each 10 ng higher level of vitamin D – Meta-analysis April 2020
- Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- Multiple Sclerosis relapses cut in half by 100,000 IU of Vitamin D every 2 weeks– RCT 2019
UV and Sunshine reduces MS risk
- Multiple Sclerosis 2X more likely if low winter UV – June 2018
- Multiple Sclerosis half as likely if get plenty of sunshine (not a news item) – March 2018
Other things also help
- Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT July 2018
- Multiple Sclerosis 40 percent less likely if consume tinned fish (Vitamin D and Omega-3) – Sept 2019
- Resveratrol treats Multiple Sclerosis and other autoimmune diseases – many studies
- Not a single case of multiple sclerosis in 15,000,000 people (plant-based diets)
High Dose Vitamin D and cofactors
- Coimbra protocol using high-dose Vitamin D is safe – April 2022
- The use of high dose Vitamin D (Coimbra Protocol) for multiple sclerosis in Germany – 2019
- Comparing High-dose vitamin D therapies MS and other health problems
Number of MS studies which are also in other categories
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22 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells 14 studies in Vitamin D Receptor - gene which restricts D from getting to the cells 7 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells 21 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS
Oxidative stress (OS) plays an essential role in demyelination and tissue injury related to pathogenesis of multiple sclerosis (MS). On the other hand, vitamin D (VD) as an antioxidant reduces oxidative stress and has been used as adjuvant therapy in autoimmune diseases. Although VD supplementation is suggested as a protective and immunomodulation factor for MS patients, the molecular mechanisms remain unclear. Given that VD may modulate the immune system of MS patients through the DNA repair pathway, we aimed to evaluate the effects of VD supplementation in DNA repair genes expression including OGG1, MYH, MTH1, and ITPA. Transcript levels were measured using the RT-qPCR method in peripheral blood mononuclear cells (PBMCs) of relapsing-remitting multiple sclerosis (RRMS) patients before and after two months of VD supplementation. Furthermore, in silico analysis and correlation gene expression analysis was performed to find the biological binding sites and the effect of NRF2 on the regulation of DNA repair genes.Our data revealed that in MS patients, 2‐month VD treatment significantly altered the expression of MYH, OGG1, MTH1, and NRF2 genes. A significant correlation was observed between DNA repair genes and NRF2 expression, which was confirmed by the presence of antioxidant response element (ARE) binding sites in the promoter of OGG1, MYH, and MTH1 genes. This study demonstrated that the impact of VD on MS patients may be mediated through the improvement of DNA repair system efficiency. This finding brought some new evidence for the involvement of DNA repair genes in the physiopathology of MS patients.
Vitamin D supplementation increases the genes that repair Multiple Sclerosis – Feb 2021Printer Friendly Follow this page for updates1969 visitors, last modified 03 Mar, 2021, This page is in the following categories (# of items in each category)