Rickets is typically due to little Vitamin D getting the cells - April 2024

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Diagnosis, treatment, and management of rickets: a position statement from the Bone and Mineral Metabolism Group of the Italian Society of Pediatric Endocrinology and Diabetology

Front Endocrinol (Lausanne) . 2024 Apr 19:15:1383681. doi: 10.3389/fendo.2024.1383681
Giampiero I Baroncelli # 1, Pasquale Comberiati # 1 2, Tommaso Aversa 3 4, Federico Baronio 5, Alessandra Cassio 5 6, Mariangela Chiarito 7, Mirna Cosci O di Coscio 1, Luisa De Sanctis 8, Natascia Di Iorgi 9 10, Maria Felicia Faienza 7, Danilo Fintini 11, Roberto Franceschi 12, Mila Kalapurackal 13, Silvia Longhi 13, Michela Mariani 11, Marco Pitea 14, Andrea Secco 15, Daniele Tessaris 8, Francesco Vierucci 16, Malgorzata Wasniewska 3, Giovanna Weber 14, Stefano Mora 17 Italy

Rickets results from impaired mineralization of growing bone due to alterations in calcium and phosphate homeostasis. Clinical signs of rickets are related to the age of the patient, the duration of the disease, and the underlying disorder. The most common signs of rickets are swelling of the wrists, knees or ankles, bowing of the legs (knock-knees, outward bowing, or both) and inability to walk. However, clinical features alone cannot differentiate between the various forms of rickets. Rickets includes a heterogeneous group of acquired and inherited diseases. Nutritional rickets is due to a deficiency of vitamin D, dietary calcium or phosphate. Mutations in genes responsible for vitamin D metabolism or function, the production or breakdown of fibroblast growth factor 23, renal phosphate regulation, or bone mineralization can lead to the hereditary form of rickets. This position paper reviews the relevant literature and presents the expertise of the Bone and Mineral Metabolism Group of the Italian Society of Pediatric Endocrinology and Diabetology (SIEDP). The aim of this document is to provide practical guidance to specialists and healthcare professionals on the main criteria for diagnosis, treatment, and management of patients with rickets. The various forms of rickets are discussed, and detailed references for the discussion of each form are provided. Algorithms to guide the diagnostic approach and recommendations to manage patients with rare forms of hereditary rickets are proposed.
 Download the PDF from VitaminDWiki

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Rickets Genes and Genetics chart from VitaminDWiki

Note: <13% of Genetic causes of rickets are due to Vitamin D genes (Perplexity AI)

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VitaminDWiki – Overview of Rickets and vitamin D contains

Rate of rickets is usually < 0.1% of births, unless dark skin, breastfed, preemie, twin, Mongolian, or Russian
Rate of rickets has greatly increased with the drop in vitamin D levels during the past 40 years
400 IU can prevent/treat most rickets Turkey gave vitamin D to EVERY child and eliminated Rickets
Can have rickets without a low serum level of vitamin D (~20% of the time)
Giving enough Vitamin D to the mother (before and after birth) PREVENTS most forms of Rickets
Rate of rickets in some countries varies from 10% to 70% (typically poor health overall)
Rickets has been more than doubling in many countries
Rickets is strongly associated with severe breathing problems (weak ribs)
Bowed legs is not the primary indication of rickets    (3 other indications of rickets are seen more often)
Rickets is typically due to low cellular Vitamin D - April 2024
Some Rickets is due to poor genes - Vitamin D needed lifelong – June 2020
Vitamin D and Rickets consensus took 80 years

Rickets category has 127 items

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Breathing

• Children with pneumonia in Ethiopia were 22X more likely to have rickets – 1997
• Largest cause of infant deaths is respiratory infections, which is associated with low vitamin D – April 2011
• Rickets in 80 percent of infants with severe pneumonia – Sept 2010

History

• Majority of Medici in 1600's who died in infancy had rickets - 2013
• Rickets associated with 30 percent of infant deaths in rural Netherlands in 1800’s– June 2013
• Vitamin D, Cod-Liver Oil, Sunlight, and Rickets: A Historical Perspective – 2003
• What causes Rickets - 1919
• Vitamin D reduced so low that Victorian age diseases are returning

Turkey

• Nutritional rickets. In Turkey – 2010
• 400 IU vitamin D appeared to prevent infant rickets in Turkey – June 2011
• Turkey gave 400 IU vitamin D to all infants and reduced Rickets by 60X - 2011
• Infants again said to need more than 400 IU of vitamin D – Sept 2012 not enough in winter

Mongolia

• Rickets very prevalent in Mongolia – 1998
• Rickets in Mongolia - July 2013
• Mongolian women have the lowest levels of vitamin D in the world – Sept 2013

Other countries

• Calcium reduced some rickets in Nigerian children – Feb 2012
• Rickets in Ethiopia – review July 2005
• Vitamin D deficiency spares no body part – NE Asia – Jan 2013
• Vitamin D deficiency in Middle East and North Africa - June 2013 from XML with maps
• Hypovitaminosis D in the Middle East and North Africa - May 2013 from HTML
• Rickets: Less costly to prevent than to treat SE Asians in UK – 2006
• Rickets in 30 percent of infants in India who had low vitamin D – March 2011
• Perhaps half of Russian children have rickets, 500 IU vitamin D was not enough – June 2013
• Maternal vitamin D deficiency can trigger rickets in breastfed infants – review March 2013

Rickets - World

• Nutritional rickets around the world: an update - 2016
  PDF is available free at Sci-Hub   10.1080/20469047.2016.1248170
  Nigeria 1 in 170; Gambia 1 in 70; Bangladesh 1 in 12

Recent Increase

• Rickets in Sweden recently increased by 6X (mainly preemies) – May 2019
• Rickets in Japan increased 3 X recently, similar to increases in other countries – June 2017
• Rickets in UK increased 4X in a decade - May 2015
• Rare Nutritional Rickets increased 10X in 20 years – Feb 2013

Prevention and treatment

• Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT Nov 2018
• Rickets needs Vitamin D and Calcium - Global Consensus Jan 2016
• Neonate Rickets was virtually always associated with very low maternal vitamin D – Dec 2014
      pehaps giving mothers Vitamin D would be better
• Rickets prevented by single injection of vitamin D or weekly supplementation – RCT Jan 2014
• Group is giving only 200 IU of Vitamin D to 70 million women and children to prevent Rickets
• Rickets reduced 60X - lessons learned by Turkey 2011
• Recommend 400 IU to prevent rickets – Mar 2010
• 400 IU vitamin D for infants and 2000 IU during pregnancy if high risk – June 2010
• Giving vitamin D to ALL children reduced (rickets) symptoms by 60 percent – Aug 2012
• 744 IU vitamin D needed by Northern white teens to prevent Rickets – Jan 2011
• Took 4 months of 400 IU vitamin D for Iranian infants to get serum level of 30 ng – June 2013 loading dose was far faster
• Rickets cured for 3 months with 10,000 IU per kg vitamin D (600,000 IU max) – Sept 2012
  • Vitamin D within 3-5 days of birth prevents all rickets - Dec 2013 article at the bottom of this page

Shaken-baby syndrome

• Child abuse, vitamin D deficiency, or what - for parents and defense attorneys - Cannell June 2015
• Mother and father on trial for infant death – set free – death was due to rickets – Dec 2011
• Lack of vitamin D in infants can result in broken bones and shaken baby syndrome - March 2010
• The Vitamin Deficiency Signs That Can Send You to Prison – Feb 2014
• Shaken Baby Syndrome - probably caused by Ehlers-Danlos Syndrome
• Child abuse fractures – 96 percent were associated with poor bones (low vitamin D, etc.) – Oct 2019
• Shaken Baby Syndrome - Movie April 2016
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Associated with Dark skin and breastfed

• Ricket was known to be associated with dark skin and breast feeding a century ago - 2005
• Black Sudanese children 350X more likely to have rickets than other Australians – April 2012
• Dark Skinned babies probably need vitamin D to prevent nutritional rickets - 2001
• Nutritional Rickets in Denmark especially among immigrant children- Feb 2012
• 16% of exclusively breastfed infants so low on vitamin D that they had rickets – June 2010

Animals

• Rickets in Humans and domestic animals - March 2011
• Rickets increasing in dogs

Rickets Other

• Search VitaminDWiki for "RESISTANT RICKETS 195 items as of Dec 2018
• Types of Rickets and rickets in Denmark – Feb 2012
• Rickets-vitamin D deficiency and dependency – March 2012
• Rickets and vitamin D overview – Lancet 2003
• Sunlight for babies – US Govt 1933
• Osteopenia in preterm infants – May 2012
• Further look at vitamin D dependent rickets and gene mutations – Feb 2011
• Vitamin D Levels in Kids are So Low that Rickets is Back with a Vengeance
• Fastest bone growth occurs before age 2
• Rickets: Calcium, Genes, etc - Jan 2013
• A Critical Review of the Classic Metaphyseal Lesion: Traumatic or Metabolic? Jan 2014
  No such attachment on this page

How much Vitamin D needed to stop rickets

• Rickets can be suspected below 36 ng of vitamin D – Oct 2012
• Austrailia still believes 20 ng of vitamin D will provide bone health and stop rickets Oct 2013, not on VitaminDWiki

Other Vitamin D

• Third study found that Infants needed 1600 IU of vitamin D – JAMA RCT May 2013
• Vitamin D (40-70 ng) in Children’s Health – review Sept 2014
• Breastfed infants: 90 percent had less than 20 ng of vitamin D, formula-fed: 15 percent – May 2013
• Many preemies need at least 800 IU of vitamin D – RCT May 2013
• 75 percent of unexplained sudden infant deaths had inadequate level of vitamin D – April 2013
• Dark skin pregnancies and Vitamin D - many studies
• Overview Deficiency of vitamin D
• Overview UV and vitamin D Sun is better than UV, which is better than supplements
• Many reasons why vitamin D deficiency has become epidemic 19 new reasons (40 total as of 2023)
• Quick, FREE, self-test for Vitamin D deficiency sore bones is one indication of rickets