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- Association between Vitamin D Receptor Gene Polymorphisms and Periodontal Bacteria: A Clinical Pilot Study
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7 studies in both categories Dental and Vitamin D Receptor - VitaminDWiki - Dental category contains
- VitaminDWiki - The Vitamin D Receptor is associated with many health problems
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Association between Vitamin D Receptor Gene Polymorphisms and Periodontal Bacteria: A Clinical Pilot Study
Biomolecules. 2022 Jun 15;12(6):833. doi: 10.3390/biom12060833.
Concetta Cafiero 1, Cristina Grippaudo 2, Marco Dell'Aquila 3, Pasquale Cimmino 4, Antonio D'Addona 2, Paolo De Angelis 2, Maria Pia Ottaiano 5, Domenico Costagliola 5, Giulio Benincasa 5, Alessandra Micera 6, Luigi Santacroce 7, Raffaele Palmirotta 7Background: Periodontitis is an inflammatory disease caused by microorganisms involving the supporting tissues of the teeth. Gene variants may influence both the composition of the biofilm in the oral cavity and the host response. The objective of the study was to investigate the potential correlations between the disease susceptibility, the presence and the quantity of periodontopathogenic oral bacterial composition and the VDR gene polymorphisms.
Methods: Fifty (50) unrelated periodontal patients and forty-one (41) healthy controls were selected for genomic DNA extraction. DNA concentration was measured and analyzed. The periodontopathogenic bacterial species were identified and quantified using a Real Time PCR performed with species-specific primers and probes.
Results: Genotype distribution showed a different distribution between the groups for BsmI rs1544410 genotypes (p = 0.0001) with a prevalence of the G(b) allele in periodontal patients (p = 0.0003). Statistical significance was also found for VDR TaqI rs731236 (p ≤ 0.00001) with a prevalence of the T(T) allele in periodontal patients (p ≤ 0.00001). The average bacterial copy count for the periodontitis group was significantly higher than that of control group. Dividing patients into two groups based on high or low bacterial load, FokI rs2228570 T allele (f) was statistically more represented in patients with high bacterial load.
Conclusions: The findings of the study suggest the involvement of the VDR gene BsmI and TaqI polymorphisms in periodontal disease, while FokI and BsmI may be involved in determining an increased presence of periodontopathogens.
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7 studies in both categories Dental and Vitamin D Receptor This list is automatically updated
- Malocclusions 5X higher risk if poor Vitamin D Receptor or low Vitamin D - Feb 2024
- Poor oral bacteria associated with poor Vitamin D Receptor - June 2022
- Periodontitis problems often 3X more likely if poor Vitamin D receptor – May 2022
- 1.8 X more likely to have additional Dental Implant Failure if poor Vitamin D Receptor – Dec 2019
- Early tooth decay 1.9 X more likely if a poor Vitamin D receptor – July 2017
- Chronic Periodontitis 9.6 times more likely if smoke and have poor Vitamin D Receptor – Aug 2016
- Dental caries associated with poor Vitamin D receptor – 2016
VitaminDWiki - Dental category contains
116 Dental items Some Dental studies
- Vitamin D cut dental caries in half 80 years ago – meta-analysis 2013 80 years ago
- Caries (tooth decay) and Vitamin D - 23+ studies
- Periodontitis reduced by Vitamin D - many studies
- Risk of Oral Surgery reduced by Vitamin D – scoping review Nov 2021
- Some Dental Malocclusions 5X more likely if low vitamin D – June 2021
- Grinding teeth while sleeping (sleep bruxism) 6 X more likely if low vitamin D – Jan 2021
- Early tooth decay 1.9 X more likely if a poor Vitamin D receptor – July 2017
7 Intervention AND Dental studies 19 items listed in BOTH Dental and Infant or Child 7 listed in BOTH Dental and Vitamin D Receptor
VitaminDWiki - The Vitamin D Receptor is associated with many health problems
Health problems include: Autoimmune (19 studies), Breast Cancer ( 24 studies), Colon Cancer ( 13 studies), Cardiovascular ( 23 studies), Cognition ( 16 studies), Diabetes ( 24 studies), Hypertension ( 9 studies), Infant ( 22 studies), Lupus ( 6 studies), Metabolic Syndrome ( 4 studies), Mortality ( 4 studies), Multiple Sclerosis ( 14 studies), Obesity ( 17 studies), Pregnancy ( 24 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 37 studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
VitaminDWiki - Vitamin D Receptor activation can be increased by any of
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators
Poor oral bacteria associated with poor Vitamin D Receptor - June 2022Printer Friendly Follow this page for updates5570 visitors, last modified 24 Jun, 2022, This page is in the following categories (# of items in each category)