Fibromyalgia and Musculoskeletal Pain treated by raised Vitamin D levels – July 2022

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The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain

Nutrients 2022, 14(15), 3010; https://doi.org/10.3390/nu14153010
by Mauro Lombardo 1,*ORCID,Alessandra Feraco 1,2,Morena Ottaviani 1,Gianluca Rizzo 3ORCID,Elisabetta Camajani 1,4ORCID,Massimiliano Caprio 1,2ORCID andAndrea Armani 1,2
1 Dept. of Human Sciences and Promotion of the Quality of Life, San Raffaele Open University, 00166 Rome, Italy
2 Lab. of Cardiovascular Endocrinology, San Raffaele Research Institute, IRCCS San Raffaele Roma, Via di Val Cannuta, 247, 00166 Rome, Italy
3 Independent Researcher, Via Venezuela 66, 98121 Messina, Italy
4 PhD Program in Endocrinological Sciences, Dept of Experimental Medicine, U. of Rome “La Sapienza”, Piazzale Aldo Moro, 5, 00185 Rome, Italy

Fibromyalgia syndrome (FMS) and chronic widespread musculoskeletal pain (CMP) are diffuse suffering syndromes that interfere with normal activities. Controversy exists over the role of vitamin D in the treatment of these diseases. We carried out a systematic literature review of randomized controlled trials (RCT) to establish whether vitamin D (25OHD) deficiency is more prevalent in CMP patients and to assess the effects of vitamin D supplementation in pain management in these individuals. We searched PubMed, Physiotherapy Evidence Database (PEDro), and the Cochrane Central Register of Controlled Trials (CENTRAL) for RCTs published in English from 1 January 1990 to 10 July 2022. A total of 434 studies were accessed, of which 14 satisfied the eligibility criteria. In our review three studies, of which two had the best-quality evidence, a correlation between diffuse muscle pain and 25OHD deficiency was confirmed. Six studies, of which four had the best-quality evidence, demonstrated that appropriate supplementation may have beneficial effects in patients with established blood 25OHD deficiency. Eight studies, of which six had the best-quality evidence, demonstrated that 25OHD supplementation results in pain reduction. Our results suggest a possible role of vitamin D supplementation in alleviating the pain associated with FMS and CMP, especially in vitamin D-deficient individuals.

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VitaminDWiki - Overview Fibromyalgia or Chronic Fatigue and vitamin D

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VitaminDWiki - Pain - chronic category contains

168 items in category Chronic pain

See also

• Overview Pain and Vitamin D
• Percentage of people with pain increased 25 percent in 18 years – Jan 2019
• Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
• Overview Fibromyalgia or Chronic Fatigue and vitamin D
• Overview Rheumatoid Arthritis and vitamin D
• Shingles and vitamin D
• Shin splints decrease with vitamin D
• Migraine and Vitamin D
• Headache category 82 items
• "musculoskeletal pain" 490 items as of Aug 2023
• "chronic fatigue" 240 items have it in title or abstract as of Dec 2024
• Category Back Pain 44 items
• 7 pain studies in VitaminDWiki with KNEE in the title as of Aug 2023 (see below)
• Opioid OR Opiate OR Morphine in the title 14 pages as of Dec 2024