Impact of oral vitamin D (cholecalciferol) replacement therapy on blood pressure in type 2 diabetes patients; a randomized, double-blind, placebo controlled clinical trial.
J Nephropathol. 2014 Jan;3(1):29-33. doi: 10.12860/jnp.2014.07. Epub 2013 Dec 25.
Nasri H1, Behradmanesh S2, Ahmadi A3, Rafieian-Kopaei M4.
1Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.
2Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
3Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Background: Vitamin D is an important mediator of calcium metabolism. It has also been implicated as a potential contributor to the pathophysiology of various extra-skeletal conditions, consisting hypertension, renal disease, and insulin resistance.
Objectives: The primary objective of this study was to determine whether oral vitamin D (cholecalciferol) supplementation can lead to improvement of blood pressure in type 2 diabetes patients.
Patients and Methods: This study was a double blind clinical trial conducted on 60 type 2 diabetes mellitus patients. Exclusion criteria were taking calcium, vitamin D supplements or any drugs effecting calcium and vitamin D metabolism in the past 6 months. Patients were administered weekly vitamin D supplementation (50000 units) for 12 weeks. Serum 25-Hydroxy vitamin D 25(OH)D level was measured with ELISA method.
Results: Five patients (8.3%) had vitamin D deficiency, 27 (45%) had insufficient levels of vitamin D and in 28 (45%) patients vitamin D level was within normal limits. The means of systolic blood pressure (BP) and diastolic BP in patients before intervention were 121 and 80.5 mmHg; after intervention they were 110 and 76.3 mmHg, respectively. After intervention, systolic and diastolic blood pressure levels were significantly less than control group (p< 0.01).
Conclusions: In this study we found that weekly vitamin D supplementation (cholecalciferol; 50,000 units for 12 weeks) had beneficial effect on the level of blood pressure in type 2 diabetic patients. Thus, oral vitamin D may help in improvement of hypertension in these patients.
PMID: 24644541
Summary by VitaminDWiki
| Type | Before | After |
| Systolic | 121 | 110 |
| Diastolic | 80.5 | 76.3 |
It is amazing that the blood levels dropped so much, in a such a short time, with so many patients who had acceptable vitamin D levels, with so little added vitamin D.
PDF is attached at the bottom of this page
See also VitaminDWiki
- Overview Hypertension and Vitamin D
- Overview Diabetes and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Systolic blood pressure reduced by vitamin D (many studies)
- Items in BOTH Hypertension AND Diabetes are:
- Vitamin D Roles - more than just help the immune system
- Magnesium Depletion Score predicts increased risk of various health problems
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- COVID-19 hospitalizations: 63% associated with diabetes, obesity, hypertension or heart failure – Feb 2021
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Vitamin D deficiency associated with increased risk of many health problems in 58,000,000 Americans - Nov 2020
- COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
- Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019
- Upsurge in Metabolic diseases may be due to low vitamin D – May 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Pre-diabetes and hypertension 2.4X more common when less than 30 ng of vitamin D – Jan 2011
- Items in BOTH Metabolic Syndrome AND Diabetes are:
- Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
- UV reduces cardiovascular and metabolic problems– Vitamin D plus Nitric oxide – Sept 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- How Vitamin D prevents Insulin Resistance – Sept 2020
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Cardiometabolic risk reduced by Omega-3 - dissertation Sept 2017
- Upsurge in Metabolic diseases may be due to low vitamin D – May 2016
- Psoriasis is associated with kidney disease, heart problems, diabetes, etc – Nov 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
- Cardiometabolic markers indicate that 11-14 ng is enough vitamin D – Nov 2013
- Metabolic Syndrome 10% less likely for every 4 ng increase in Vitamin D – Jan 2013
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Overview Metabolic Syndrome and vitamin D