Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017

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The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements

Nutrients 2017, 9(11), 1244; doi:10.3390/nu9111244
Naghmeh Mirhosseini 1, Hassanali Vatanparast 2, and Samantha M. Kimball 1,*
1 Pure North S’Energy Foundation, Calgary, AB T2R 0C5, Canada
2 College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada

Background: Vitamin D deficiency is a risk factor for hypertension.

Methods: We assessed 8155 participants in a community-based program to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) status and blood pressure (BP) and the influence of vitamin D supplementation on hypertension. Participants were provided vitamin D supplements to reach a target serum 25(OH)D > 100 nmol/L. A nested case-control study was conducted to examine the effect of achieving physiological vitamin D status in those who were hypertensive and not taking BP-lowering medication, and hypertensive participants that initiated BP-lowering medication after program entry.

Results: At baseline, 592 participants (7.3%) were hypertensive; of those, 71% were no longer hypertensive at follow-up (12 ± 3 months later). There was a significant negative association between BP and serum 25(OH)D level (systolic BP: coefficient = −0.07, p < 0.001; diastolic BP: coefficient = −0.1, p < 0.001). Reduced mean systolic (−18 vs. −14 mmHg) and diastolic (−12 vs. −12 mmHg) BP, pulse pressure (−5 vs. −1 mmHg) and mean arterial pressure (−14 vs. −13 mmHg) were not significantly different between hypertensive participants who did and did not take BP-lowering medication.

Conclusion: Improved serum 25(OH)D concentrations in hypertensive individuals who were vitamin D insufficient were associated with improved control of systolic and diastolic BP.

Clipped from PDF
“After correcting for probable confounding factors. . . only those participants that were vitamin D insufficient at baseline that achieved optimal serum 25(OH)D status at follow-up (≥100 nmol/L) had a lower risk of hypertension (OR = 0.10, 95% CI: 0.01, 0.87, p = 0.03).”
 Download the PDF from VitaminDWiki

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Notice the improved health vs vitamin D levels BEFORE the addition of vitamin D

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VitaminDWiki

• Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
• Daily average of 3600 IU Vitamin D helped hypertensives – Jan 2013
• Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
• Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT Oct 2017
• Hypertension 5 X more likely if low Vitamin D, A, Calcium and Magnesium – June 2016
• Hypertension not reduced by drugs (Resistant Hypertension) in patients with low vitamin D
• Hypertension not reduced much if use less than 5,000 IU of Vitamin D – meta-analysis June 2018

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VitaminDWiki - Hypertension category contains

166 items in the category HYPERTENSION

see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies

• Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017
• Hypertension risk reduced 4X if adequate level of Vitamin D – July 2024
• COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
• Magnesium reduces hypertension - FDA allows claim - Jan 2022
• Drug-resistant hypertension 3.5 X more likely if low vitamin D – March 2020
• High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019
• Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
• Hypertension is associated with low vitamin D in some groups – meta-analysis April 2015
• Off Topic – Hypertension in 42 percent of adults (new definition: 130 mm Hg) – Feb 2018
  • Men aged 40-59 59%, age >60 75%: National Health and Nutrition Examination Survey, 2017–2018

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Study was cited 90 times as of July 2023

Google Scholar

• Vitamin D deficiency 2.0: an update on the current status worldwide - Jan 2020  PDF
• A Narrative Review of the Evidence for Variations in Serum 25-Hydroxyvitamin D Concentration Thresholds for Optimal Health - Feb 2022 FREE PDF https://doi.org/10.3390/nu14030639
• Circulating 25-hydroxyvitamin D levels and hypertension risk after adjusting for publication bias - May 2022 https://doi.org/10.1186/s40885-022-00196-4
  • NO statistically significant relationship
• High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients - 2021 FREE PDF