Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015

Two meta-analyses in 2015 and one in 2017: all with same conclusion

Rheumatoid arthritis 40% more likely if poor Vitamin D Receptor – meta-analysis - Feb 2017

Association between Vitamin D Receptor polymorphisms and rheumatoid arthritis risk: a meta-analysis
Int J Clin Exp Med 2017;10(2):4221-4233 www.iicem.com /ISSN:1940-5901/IJCEM0045890, Published February 28, 2017
Wei Wang1, Ailing Wu2, Yongqiang Zhou1, Yongping Wang1, Kuangzhong Cao1
Departments of1Orthopedics, 2Anesthesiology, The First People’s Hospital of Neijiang, Neijiang 641000, Sichuan, China

The aim of this study was to identify whether vitamin D receptor (VDR) variants were implicated in Rheumatoid arthritis (RA) pathogenesis. Relevant case-control studies published between 2000 and 2016 were searched in electronic databases. Odds ratio (OR) with its corresponding 95% confidence interval (CI) were employed to calculate extracted data. Total fourteen studies were screened out, including 2359 patients and 2764 controls, and focusing on four genetic variants (TaqI, BsmI, FokI and Apal). Our results found that T allele of TaqI (T vs. t: OR=1.40, 95% CI=1.08-1.82, P=0.01), B allele of BsmI (B vs. b: OR=0.84, 95% CI=0.75-0.94, P=0.003), and F allele of FokI (F vs. f: OR=1.2495% CI=1.05-1.47, P=0.01) polymorphisms were associated with increased the risk of RA in total populations. This significant association was also found in TT genotype of TaqI, BB genotype and Bb genotyps of BsmI, and FF and Ff genotypes of FokI. Subgroup analysis found that BsmI variant among Africans, FokI variant among Asians and Caucasians were significantly increased the risk of RA. No relationship was found between ApaI variant and Ra risk. Our results demonstrated that polymorphisms of TaqI, BsmI, FokI, not ApaI in VDR gene might be involved in the development of RA.

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Rheumatoid arthritis 40% more likely if poor Vitamin D Receptor – meta-analysis - June 2015

Association between VDR polymorphisms and rheumatoid arthritis disease: Systematic review and updated meta-analysis of case–control studies
Immunobiology, Volume 220, Issue 6, June 2015, Pages 807–816, http://dx.doi.org/10.1016/j.imbio.2014.12.013
Kalthoum Tizaoui, , Kamel Hamzaoui

Background: Vitamin D receptor (VDR) polymorphisms have been inconsistently investigated in rheumatoid arthritis (RA). However, published studies demonstrated differences concerning design and effect size. A meta-analysis is necessary to determine the magnitude of the association between VDR polymorphisms and RA risk.

Objective: The aim of the current study was to quantify the magnitude of the association between TaqI, BsmI, and FokI VDR polymorphisms with RA risk.

Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic search and meta-analysis of the literature were conducted. Analyses were performed in the random effects model by using recessive, dominant, codominant, homozygous, and allele contrast models.

Results
A total of 1703 cases and 2635 controls in 12 case–control studies were included in the meta-analyses. Results indicated a significant association between TaqI polymorphism and RA disease in homozygous, codominant and allele contrast models (P = 0.008, P = 0.015, P = 0.006 and P = 0.002, respectively). Association between BsmI polymorphism and RA risk was marginal in the dominant, codominant and allele contrast models (P = 0.057, P = 0.071, and P = 0.069, respectively). Te association between FokI polymorphism and RA risk was significant in the recessive, dominant and allele contrast models (P = 0.045, P = 0.027, and P = 0.013, respectively). Subgroup analysis showed that publication year, ethnicity, age, latitude, and estimated 25(OH)D levels influenced significantly the association between VDR polymorphisms and RA risk.

Conclusion: TaqI and FokI VDR polymorphisms contributed significantly to RA risk. Study characteristics influenced the association between VDR polymorphisms and RA disease.

Behind publisher paywall but available via DeepDyve (2 week free trial)

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Vitamin D receptor Fok, BsmI, and TaqI polymorphisms and susceptibility to rheumatoid arthritis – A meta-analysis - Sept 2015

Journal of Rheumatology. First online: 12 September 2015
GG Song, S.-C. Bae, YH Lee

Objective: The aim of this study to explore what Whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA).

Methods: Meta-analyzes were Conducted on the associations between the VDR FokI, BsmI, and TaqI polymorphisms and RA.

Results
A total of seven studies were Considered in the meta-analysis, Involving a total of 923 patients and 912 controls. Meta-analysis of the VDR FokI polymorphism Showed no association between RA and the F alleles in the Entire of studied cohort (odds ratio, OR = 1.1740 95% confidence interval, CI = 0994-1387, p  = 0.059).
HOWEVER, stratification by ethnicity revealed a significant association between the F allele and RA in Europeans (OR = 1.402, 95% CI = 1126-1746, p  = 0.003). Further More, at what association found between RA and the VDR FokI polymorphism using Both the dominant model and homozygous contrast.
Meta-analysis revealed no association between RA and the VDR BsmI B and TaqI T polymorphisms in Europeans (OR Hanes B alleles = 1.065, 95% CI = 0911-1245, p  = 0.427; OR = 1.065 for the T allele, 95% CI = 0834-1361, p  = 0.613).

Conclusion
This meta-analysis Suggests That the VDR FokI polymorphism is associated with susceptibility to RA in European populations.

Publisher wants $40 for the PDF

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Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint - Oct 2017

Technical details of how Vitamin D Receptor limits vitamin D getting to rheumatoid arthritis cells
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See also VitaminDWiki

Rheumatoid Arthritis category starts with

118 RA items     See also Overview Rheumatoid Arthritis   Autoimmune  Inflammation   Pain - Chronic

    Highlights of RA studies in VitaminDWiki
RA worse if low Vitamin D

• Rheumatoid Arthritis score extrapolates to zero at 51 ng of Vitamin D (India) – June 2024
• Rheumatoid Arthritis is more severe if low vitamin D – July 2023
• Rheumatoid arthritis pain was 5.8 X more likely if low vitamin D – Aug 2017
• Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019
• Rheumatoid Arthritis strongly associated with low vitamin D – meta-analysis April 2016
• Rheumatoid Arthritis associated with lower vitamin D and higher latitude – meta-analysis Jan 2016

10 RA and Vitamin D Receptor (auto-updated)

RA Treated by Vitamin D

• Several rheumatic diseases treated by high-dose vitamin D, but made worse if Calcium was added – April 2022
• Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
• Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
• Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months – Oct 2015
• Connective tissue disorders (Lupus, RA, etc) treated by vitamin D – May 2016
• 43 percent of Rheumatoid Arthritis patients have Vitamin D prescriptions (15 countries) – June 2017
• Big increase in vitamin D supplementation in just 2 years after Swiss rheumatology report – Dec 2013
• High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015
  • Note: Vitamin D receptor problems (such as RA) are best treated by infrequent large doses of Vitamin D

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Items in both categories Rheumatoid Arthritis and Vitamin D Receptor

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Vitamin D Receptor category has the following

530 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (14 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR