Vitamin D, Autoimmune Disease and Rheumatoid Arthritis
Calcified Tissue International, pp 1–18
Stephanie R. Harrison Danyang Li Louisa E. Jeffery Karim Raza Martin Hewison Email author
Rheumatoid Arthritis and Genes
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Resveratrol activated the vitamin D receptor and increases the amount of vitamin D which gets to the tissue
- Arthritis runs in Pakistani families (Vitamin D Receptor) – March 2019
- Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017
- Rheumatoid Arthritis synovial fluid has lower levels Vitamin D binding protein, 3-epi – Jan 2019
- Poor VDBP, like poor VDR, also results in less Vitamin D getting to the tissue
Rheumatoid Arthritis and Large (non-daily) doses
Note: large doses get past poor Vitamin D Receptors
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
- Rheumatoid Arthritis nicely treated by Vitamin D (300,000 IU loading dose) – May 2017
Genes in VitaminDWiki
- Search VitaminDWiki for CYP27B1 gene 1560 items as of July 2019
- Vitamin D Binding Protein (DBP) category listing has 178 items along with related searches
- The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019
Download the PDF from VitaminDWiki
Vitamin D has been reported to influence physiological systems that extend far beyond its established functions in calcium and bone homeostasis. Prominent amongst these are the potent immunomodulatory effects of the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3). The nuclear vitamin D receptor (VDR) for 1,25-(OH)2D3 is expressed by many cells within the immune system and resulting effects include modulation of T cell phenotype to suppress pro-inflammatory Th1 and Th17 CD4+ T cells and promote tolerogenic regulatory T cells. In addition, antigen-presenting cells have been shown to express the enzyme 1α-hydroxylase that converts precursor 25-hydroxyvitamin D3 (25-OHD3) to 1,25-(OH)2D3, so that immune microenvironments are able to both activate and respond to vitamin D. As a consequence of this local, intracrine, system, immune responses may vary according to the availability of 25-OHD3, and vitamin D deficiency has been linked to various autoimmune disorders including rheumatoid arthritis (RA). The aim of this review is to explore the immune activities of vitamin D that impact autoimmune disease, with specific reference to RA. As well as outlining the mechanisms linking vitamin D with autoimmune disease, the review will also describe the different studies that have linked vitamin D status to RA, and the current supplementation studies that have explored the potential benefits of vitamin D for prevention or treatment of RA. The overall aim of the review is to provide a fresh perspective on the potential role of vitamin D in RA pathogenesis and treatment.