- Vitamin D receptor FokI polymorphism and the risks of colorectal cancer, inflammatory bowel disease, and colorectal adenoma.
- VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
- Items in both categories Cancer- Colon and VDR are listed here:
- Items in both categories Gut and VDR are listed here:
- Items listed in BOTH the categories Colon Cancer and Genetics (other than VDR) are listed here
- Overview Gut and vitamin D contains gut-friendly information
Vitamin D receptor FokI polymorphism and the risks of colorectal cancer, inflammatory bowel disease, and colorectal adenoma.
Sci Rep. 2018 Aug 27;8(1):12899. doi: 10.1038/s41598-018-31244-5.
Cho YA1, Lee J1, Oh JH2, Chang HJ2, Sohn DK2, Shin A3, Kim J4.
1 Dept of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea.
2 Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, South Korea.
3 Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
4 Dept of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea. jskim at ncc.re.kr.
- Inflammatory Bowel Disease associated with low Vitamin D, low Zinc, and low Selenium – May 2017
- Inflammatory Bowel Disease and Vitamin D review (needs 40-50 ng) – Feb 2018
- Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators
Items in both categories Cancer- Colon and VDR are listed here:
- Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022
- 14th activator of the Vitamin D Receptor – Butyrate (from gut bacteria, or supplement)
- Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021
- Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
- Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020
- Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020
- Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019
- Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017
- Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
Items in both categories Gut and VDR are listed here:
- Ulcerative Colitis associated with a 90% reduced activation of Vitamin D Receptor – May 2024
- Crohn's and Vitamin D - many studies
- A healthy gut needs Vitamin D and a good vitamin D receptor – Sept 2022
- 14th activator of the Vitamin D Receptor – Butyrate (from gut bacteria, or supplement)
- Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020
- Microbiomes of both gut and airway are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Vitamin D Receptor, the gut, the immune system, and the Middle East – May 2019
- Inflammatory bowel disease, gut bionome and Vitamin D Receptor – 2018
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Gut and airway bionome are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally – June 2017
- Ulcerative colitis associated with both low Vitamin D and poor Vitamin D Receptors – Oct 2016
- Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015
Items listed in BOTH the categories Colon Cancer and Genetics (other than VDR) are listed here
- Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022
- Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019
- Many Ashkenazi Jewish diseases associated with low vitamin D or poor Vit D genes
- Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015
- Colorectal cancer – need more vitamin D if you have certain genes – Aug 2013
- Colon cancer more likely in blacks due to differences in Vitamin D genes (wonder if more Vitamin D would help) – May 2014
- Gene variations were not associated with risk of colorectal cancer in Czech – June 2010
Overview Gut and vitamin D contains gut-friendly information__
Getting Vitamin D into your body has the following chart
Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut
| Bio | Form | Speed | Duration |
| 10 | Injection ($$$) or Calcidiol or Calcitriol | D - Slow C -Fast | Long |
| 10 | Sun/UVB | Slow | Long |
| 10 | Topical (skin patch/cream, vagina) | Slow Fast nano | Normal |
| 9 | Nanoemulsion -mucosal perhaps activates VDR | Fast | Normal |
| 9? | Inhaled (future) | Fast | Normal |
| 8 | Bio-D-Mulsion Forte | Normal | Normal |
| 6 | Water soluble (Bio-Tech) | Normal | Normal |
| 4 | Sublingual/spray (some goes into gut) | Fast | Normal |
| 3 | Coconut oil based | Slow | Normal |
| 2 | Food (salmon etc.) | Slow | Normal |
| 2 | Olive oil based (majority) | Slow | Normal |
10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months
Download the PDF from VitaminDWiki
Based on an inverse association between vitamin D levels and the risks of colorectal diseases, a functional start codon polymorphism in the vitamin D receptor (VDR) gene is speculated to affect the risks for these diseases. To validate this hypothesis, we first conducted a case-control study of 695 colorectal cancer patients and 1,397 controls. The association of VDR FokI polymorphism with colorectal cancer risk was analyzed using a logistic regression model. In the present case-control study, compared to the F allele, the f allele seemed to be associated with lower risks of colon cancer and advanced colorectal cancer. Additionally, a meta-analysis of 27 studies was conducted to combine findings from previous studies investigating the association of FokI polymorphism with colorectal disease using a random effects model. In the present meta-analysis, the f allele was positively associated with the risk of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. However, this allele was inversely associated with colon cancer and was not associated with the risk of rectal cancer or colorectal adenoma. In conclusion, the findings from this study imply that the role of VDR FokI polymorphism may differ based on the type and severity of colorectal disease.