Depression decreased by Vitamin D (12th study in VitaminDWiki) – RCT Nov 2022

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Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial

BMC Psychiatry . 2022 Nov 11;22(1):694. doi: 10.1186/s12888-022-04305-3.
Mina Kaviani 1 , Bahareh Nikooyeh 2 , Farnaz Etesam 3 , Siroos Jahangiri Behnagh 4 , Hamed Mohammadi Kangarani 5 , Mohammad Arefi 5 , Parichehreh Yaghmaei 6 , Tirang R Neyestani 7

Background: Both augmented inflammatory reaction and low vitamin D status are associated with depression but the magnitude of their relationships is unclear. This study was, therefore, conducted to evaluate the effects of vitamin D supplementation on serum 25(OH)D concentration, depression severity and some pro-inflammatory biomarkers in patients with mild to moderate depression.

Methods: An 8-week double-blind randomized clinical trial (RCT) was performed on 56 (18-60 yrs) patients with mild to moderate depression, randomly assigned to intervention (50,000 IU cholecalciferol 2wks-1) and control (placebo) groups. Serum 25(OH)D, intact parathyroid hormone (iPTH), interlukin (IL)-1β, IL-6, high-sensitivity C-reactive protein (hs-CRP) and depression severity (Beck Depression Inventory-II) (BDI-II)) were initially and finally assessed.

Results: At the end point, statistically significant changes were observed only in intervention group as compared with controls including increased 25(OH)D concentration (+ 40.83 ± 28.57 vs. + 5.14 ± 23.44 nmol L-1, P < 0.001) and decreased depression severity (-11.75 ± 6.40 vs. -3.61 ± 10.40, P = 0.003). No significant within- or between group differences were observed in serum IL-1β, IL-6 and hs-CRP concentrations.

Conclusion: Increased circulating 25(OH)D concentrations following 8-week vitamin D supplementation (50,000 IU 2wks-1) resulted in a significant decrease in BDI-II scores in patients with mild to moderate depression. However, this effect was independent of the serum concentrations of the studied inflammatory biomarkers.

Trial registration: The clinical trial registration code was obtained from the Iranian Registry of Clinical Trials (date of registration: 17/09/2018, registration number: IRCT20170926036425N1) and ClinicalTrials.gov (date of registration: 04/12/2018, registration number: NCT03766074).
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Intervention of Vitamin D for Depression

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Meta-analyses of Vitamin D and Depression

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VitaminDWiki - Depression category contains

• Low vitamin D is associated with most types of depression, Including: Seasonal Affective Disorder. manic depression, bipolar disorder, dysthymia, Depression during/after pregnancy, Seniors, Suicide
• Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies
• Depression 1.6 X more likely if low Vitamin D, taking Vitamin D reduces depression – umbrella of meta-analyses – Jan 2023
• Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023
• Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
• Depression treated by Omega-3 (again) – meta-analysis Aug 2019
• Supplementing with Vitamin D (or getting more sun) decreases most types of depression as well as drugs
• Omega-3, Magnesium, and St. Johns' Wort also decrease depression
  • Speculate that some combination (Vit D, Omega-3, Mg, St John's) will decrease depression even more
  • Note: Both Omega-3 and Magnesium increase the amount of vitamin D which gets to tissues
• Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
• There are 268 items in the Depression category in VitaminDWiki

Some recent publications

• Depression in seniors greatly reduced by Vitamin D (50,000 IU weekly) – meta-analysis June 2023
• Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023
• Post-partum depression and low Vitamin D - many studies
• Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023

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Many other health problems fought by 50,000 IU weekly or biweekly

both:
ADHD,  Anxiety,  Asthma,  Autism,  Back Pain,  BPH (prostate),  Cancer - Breast,  Cancer - Colon,  Cancer - Prostate,  Cardiovascular,  Chronic Obstructive Pulmonary Disease,  Cognitive Decline,  Colds,  COVID,  Depression,  Diabetes,  Endometriosis,  Falls,  Fibromyalgia,  Hashimoto's Thyroiditis,  Hay Fever,  Heart Failure,  Hives,  Hypertension – Pulmonary,  Immune System,  Infant,  Inflammatory Bowel Syndrome,  Influenza,  Kidney Disease,  Knee-Pain,  Lupus,  Migraine,  Multiple Sclerosis,  Muscles - women, Obesity,  Pain - Chronic,  Pain - Growing,  PMS,  Preeclampsia,  Premature Birth,  Respiratory Tract Infection,  Schizophrenia,  Sleep-Poor,  Sleep Apnea,  Smoking,  Sports Performance,  Stroke,  Surgery,  Tonsilitis,  Tuberculosis,  Ulcerative Colitis,  Ulcers – Venous,  Urinary Tract Infection   click here for proof

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Note: Magnesium and Omega-3 work synergistically with Vitamin D - such as reducing depression

14 studies in both categories Depression and Magnesium

This list is automatically updated

28 studies in both categories Depression and Omega-3

This list is automatically updated

Many otther health problems are now fought by the combo - unware of any depression studies using the combo

Many of the high-dose vitamin D therapies include Magnesium and Omega-

39 studies in both categories Magnesium and Omega-3

This list is automatically updated