1 year to respond to monthly Calcifediol – June 2024

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Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency

Nutrients 2024, 16, 1754. https:// doi.org/10.3390/nul6111754
Marco Occhiuto 1,+ , Jessica Pepe 1,+, Luciano Colangelo 1 , Marco Lucarelli 2 , Antonio Angeloni 2, Luciano Nieddu 3, Viviana De Martino 1 , Salvatore Minisola and Cristiana Cipriani1©

Background: We assessed the long-term (24 months) efficacy and safety of monthly calcifediol (0.266 mg) in the correction and maintenance of total 25(OH)D levels in postmenopausal women with basal values <30 ng/mL.

Methods: We initially enrolled 45 consecutive patients during the period September 2019-September 2020. After an initial visit, patients were instructed to return at 3, 6, 9, 12 and 24 months for measuring serum total 25(OH)D, ionised calcium, creatinine and isoenzyme of alkaline phosphatase (bALP). Here, we report only the per-protocol analysis, because the COVID-19 pandemic precluded adherence to the scheduled visits for some patients.

Results: The patients' mean age was 62.4 ± 9.0 years. Mean basal 25(OH)D levels were 20.5 ± 5.3 ng/mL. There was a continuous increase of mean 25(OH)D values (p for trend < 0.001). However, mean values at month 24 (36.7 ± 15.9) were not significantly different in respect to values at month 12 (41.2 ± 11.18). At 24 months, only 1 out 19 patients had a value <20 ng/mL. There was a significant decrease with time of mean values of bALP (p < 0.0216), with no significant changes between 12 and 24 months. No significant changes were observed as far as ionised calcium or creatinine were concerned.

Conclusions: The long-term administration of calcifediol maintains stable and sustained 25(OH)D concentrations, with no safety concerns.
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45+ VitaminDWiki pages have CALCIFEDIOL etc. in the title

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VitaminDWiki – Calcidiol category contains:

48 items in Calcidiol category

Calcidiol = Calcifediol = 25-hydroxyvitamin D3 = 25(OH)D = semi-activated Vitamin D
See also

• Calcifediol (Calcidiol, semiactivated Vitamin D) - many studies 55 as of Jan 2024
• Tests for Vitamin D 160 items
• Calcitriol 62 items
• Injection 65 items
• Forms of Vitamin D 114 items
• Response to Vitamin D - many studies 186 as of June 2024
• Calcidiol is now available on Amazon
  (~7X more expensive than standard Vitamin D)
• Nanoemulsion Vitamin D is faster and better - many studies
  • Response to Nanoemulstion Vitamin D swished in the mouth appears to start in 2 hours
• Calcidiol - daily dose has fast response, but weekly might be better - March 2018