Asthma and Vitamin D Receptor - many pages

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10+ Vitamin D Receptor pages have ASTHMA in the title

The list is automatically updated

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Asthmatics with a poor Vitamin D Receptor were 4 X more likely to have exacerbation in 1 year - Jan 2025

Vitamin D Receptor rs2228570 Gene Polymorphism Is Associated with Asthma Severity and Exacerbations
Sekiko Uehara, Keita Hirai , Toshihiro Shirai, Hinako Otaki, Taisuke Akamatsu, Kunihiko Itoh
Biological and Pharmaceutical Bulletin 2025 Volume 48 Issue 1 Pages 86-92 DOI https://doi.org/10.1248/bpb.b24-00684

Vitamin D plays a crucial role in immune system function. Several studies have indicated that genetic variations in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP, encoded by GC gene) increase the risk of developing asthma. However, the effect of these variations on the prognosis and clinical outcomes of asthma remains unclear. This study, involving 152 adult patients with asthma, aimed to assess the influence of VDR and GC polymorphisms on asthma severity and its exacerbation. Gene polymorphisms previously associated with asthma risk were analyzed, and VDR mRNA expression levels were evaluated in peripheral blood mononuclear cells.
The AA genotype of the VDR rs2228570 polymorphism was associated with an

• elevated risk of severe asthma compared to the AG/GG genotype ( odds ratio, 3.20; 95% confidence interval [CI], 1.24–8.28).

Furthermore, patients with the rs2228570 AA genotype showed an

• elevated risk of exacerbation during the 1-year follow-up period (hazard ratio, 4.01; 95% CI, 1.75–9.15).

VDR mRNA expression was significantly reduced in patients with the AA genotype. Furthermore, the mRNA expression levels of GLCCI1, HDAC2, NR3C1, and NFE2L2, which are associated with steroid response, were reduced in patients with the AA genotype.
Our findings indicate that patients with the AA genotype of VDR rs2228570 are more likely to experience severe asthma and exacerbations. This polymorphism has the potential to reduce vitamin D efficacy by altering VDR function and expression, potentially resulting in increased inflammation and reduced steroid responsiveness in patients with asthma.
 Download the PDF from VitaminDWiki

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VitaminDWiki – Overview Asthma and Vitamin D contains

• VitaminDWiki pages containing ASTHMA in title (164 as of Nov 2024)
• Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
  • Started with 100,000 IU loading dose and has standard-of-care Asthma drug
• Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
• Those with Asthma or COPD had half the response to Vitamin D – March 2020
  • Those with Asthma need larger doses to get the same response.
  • Probably need gut-friendly Vitamin D
• CDC funded study: 1.3 X Asthma risk if vaccination contained aluminum – Sept 2022
• Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
• Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
• Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
• Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
• 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
  • CDC list of high-risk for COVID-19 includes Asthma
• Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
• Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
• Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
• Proof that Vitamin D Works 99 health problems prevented/treated as of Feb 2025
  • Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
• Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
• Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
• Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
• If high vitamin D during pregnancy the child is 5X less likely to get asthma
• Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
• Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
• The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart

click on the chart to see the study

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VitaminDWiki - The risk of 50+ diseases at least double with poor Vitamin D Receptor

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VitaminDWiki - Vitamin D Receptor activation can be increased by high-dose vitamin D, etc.

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators