- Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines
- Summary of study by Perplexity AI
- 50,000 IU of Vitamin D - many studies 184+
- VitaminDWiki - Proof that Vitamin D Works for 98+ health problems
- Introduction to Is 50 ng of vitamin D too high, just right, or not enough
- 40-150 ng of Vitamin D needed to treat some health problems
- Some categories of people are at High Risk of vitamin D deficiency
- 300+ Health problems associated with low vitamin D
- VitaminDwiki – How Much Vitamin D contains
- VitaminDWiki – Water-dispersible forms of vitamins A, D, E and K are better
Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines
Nutrients 2025, 17(2), 277; https://doi.org/10.3390/nu17020277
William B. Grant 1,*ORCID,Sunil J. Wimalawansa 2ORCID,Pawel Pludowski 3ORCID andRichard Z. Cheng 4,5,*ORCID
Vitamin D offers numerous under-recognized health benefits beyond its well-known role in musculoskeletal health. It is vital for extra-renal tissues, prenatal health, brain function, immunity, pregnancy, cancer prevention, and cardiovascular health. Existing guidelines issued by governmental and health organizations are bone-centric and largely overlook the abovementioned extra-skeletal benefits and optimal thresholds for vitamin D. In addition, they rely on randomized controlled trials (RCTs), which seldom show benefits due to high baseline 25-hydroxyvitamin D [25(OH)D] concentrations, moderate supplementation doses, and flawed study designs. This review emphasizes the findings from prospective cohort studies showing that higher 25(OH)D concentrations reduce the risks of major diseases and mortality, including pregnancy and birth outcomes.
Serum concentrations > 30 ng/mL (75 nmol/L) significantly lower disease and mortality risks compared to <20 ng/mL. With 25% of the U.S. population and 60% of Central Europeans having levels <20 ng/mL, concentrations should be raised above 30 ng/mL.
This is achievable through daily supplementation with 2000 IU/day (50 mcg/day) of vitamin D3, which prevent diseases and deaths.
Furthermore, a daily dose between 4000 and 6000 IU of vitamin D3 to achieve serum 25(OH)D levels between 40 and 70 ng/mL would provide greater protection against many adverse health outcomes. Future guidelines and recommendations should integrate the findings from observational prospective cohort studies and well-designed RCTs to improve public health and personalized care.
Download the PDF from VitaminDWiki
Summary of study by Perplexity AI
This comprehensive review examines the evidence-based health benefits of vitamin D
and recommendations for population guidelines.
Here are the key findings:
Health Benefits
Cardiovascular Disease
- Higher vitamin D levels significantly reduce cardiovascular disease risk and mortality
- Raising serum vitamin D above 40 ng/mL can lower blood pressure in hypertensive patients
Cancer Prevention
- Vitamin D reduces cancer incidence and mortality through multiple mechanisms
- Higher vitamin D levels (>60 ng/mL) associated with 80% lower breast cancer risk
- Benefits seen for colorectal, prostate, lung and other cancers
Immune Function
- Enhances innate and adaptive immunity
- Reduces risk of respiratory infections including COVID-19
- Helps prevent autoimmune conditions
Other Key Benefits
- Reduces risk of diabetes and improves glycemic control
- Supports brain health and reduces dementia risk
- Improves pregnancy outcomes and reduces complications
- Essential for bone health and dental health
Recommendations
Optimal Blood Levels
- Minimum recommended level: 30 ng/mL
- Optimal range: 40-70 ng/mL for most health benefits
- Higher levels (80-150 ng/mL) may benefit certain conditions under medical supervision
Supplementation
- Minimum recommendation: 2,000 IU/day for most adults
- 4,000-6,000 IU/day needed to achieve optimal blood levels
- Higher doses may be required for obesity, certain health conditions
Limitations of Current Guidelines
The review critiques the 2024 Endocrine Society guidelines for:
- Being too conservative in dosing recommendations
- Overlooking extensive evidence from observational studies
- Focusing primarily on bone health while ignoring broader benefits
- Not accounting for individual variations in vitamin D metabolism
The authors conclude that raising population vitamin D levels
- could significantly reduce the incidence and mortality rates for 8 of the 10 leading causes of death in the U.S.
- as well as improve various health outcomes.
50,000 IU of Vitamin D - many studies 184+
50,000 IU twice a month (3,500 IU average daily) Prevents/Treats 27 health problems
Diabetes + Heart Failure + Chronic Pain + Depression + Autism + Breast Cancer + Colon Cancer + Prostate Cancer + BPH (prostate) + Preeclampsia + Premature Birth + Falls + Cognitive Decline + Respiratory Tract Infection + Influenza + Tuberculosis + Chronic Obstructive Pulmonary Disease + Lupus + Inflammatory Bowel Syndrome + Urinary Tract Infection + Poor Sleep + Growing Pain + Multiple Sclerosis + PMS + Schizophrenia + Endometriosis + Smoking 27 problems
Note: Once a week also fights: COVID, Headaches, Colds, Fibromyalgia, Asthma, Hives, Colitis etc.
50,000 IU once a week (7,000 IU average daily) prevents/treats 61 health problems
ADHD, Anxiety, Asthma, Autism, Back Pain, BPH (prostate), Cancer - Breast, Cancer - Colon, Cancer - Prostate, Cardiovascular, Chronic Obstructive Pulmonary Disease, Cognitive Decline, Colds, COVID, Depression, Diabetes, Endometriosis, Falls, Fibromyalgia, Hashimoto's Thyroiditis, Hay Fever, Heart Failure, Hives, Hypertension – Pulmonary, Immune System, Infant, Inflammatory Bowel Syndrome, Influenza, Kidney Disease, Knee-Pain, Lupus, Migraine, Multiple Sclerosis, Muscles - women, Obesity, Pain - Chronic, Pain - Growing, PMS, Preeclampsia, Premature Birth, Respiratory Tract Infection, Schizophrenia, Sleep-Poor, Sleep Apnea, Smoking, Sports Performance, Stroke, Surgery, Tonsilitis, Tuberculosis, Ulcerative Colitis, Ulcers – Venous, Urinary Tract Infection
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VitaminDWiki - Proof that Vitamin D Works for 98+ health problems
Depression, Pneumonia (Ventilator-associated), Poor Sleep, PreDiabetes, Preeclampsia, Pre-term Birth, Prostate Cancer, Psoriasis, Quality of Life, Raynaud's Pain, Respiratory Tract Infection, Restless Leg Syndrome, Rheumatoid Arthritis, Rickets, Sarcopenia, Sepsis, Short Neonates, Sickle Cell, Stronger Senior Muscles, Survive ICU, TB, Tonsillitis, Trauma Death, Traumatic Brain Injury, Tuberculosis, Ulcerative Colitis, Urinary Tract Infection, Vaginosis, Vertigo, Warts, Weight Loss
Introduction to Is 50 ng of vitamin D too high, just right, or not enough
- A few governments say 10 ng is OK
- Some governments say 20 ng is OK
- Some governments say 30 ng is OK
- Most experts say 40 ng is good
- Some experts say 50 ng is much better for disease prevention
- A few people think that > 80 ng is needed to deal with possible vitamin D restrictions due to genes
- One doctor found that >80 ng was the right level for 2,000 patients in his clinic
- Health problems that run in families are often associated with low vitamin D
- Some experts say 50 ng is too much
- Some concern that >40 ng may be too much if taking some fixed chemotherapy or not adjust cofactors
- Some experts feel 50 ng is not enough to TREAT some diseases
- Consensus: 0 ng is bad and 30 ng is good/ok
Notional Graph of Expert Opinions of levels with Vitamin D MONOTHERAPY
Note: Monotherapy just increases vitamin D levels, and rarely adjusts the cofactor intake (Ca, Mg, Vitamin K2, Omega-3, etc)
40-150 ng of Vitamin D needed to treat some health problems
| Vitamin D | Treats |
| 150 ng | Multiple Sclerosis * |
| 80 ng | Cluster Headache * Reduced office visits by 4X * |
| 70 ng | Sleep * |
| 60 ng | Breast Cancer death reduced 60% Preeclampsia RCT |
| 50 ng | COVID-19 T1 Diabetes Fertility Psoriasis Infections Review Infection after surgery |
| 40 ng | Breast Cancer 65% lower risk Depression ACL recovery Hypertension Asthma? |
| 30 ng | Rickets |
* Evolution of experiments with patients, often also need co-factors
Some categories of people are at High Risk of vitamin D deficiency
Those at high-risk of being Vitamin D deficient will require about 1.5X more vitamin D to restore their levels
Those who are at risk due to being obese need about 2X more vitamin D to restore their levels
Overview Dark Skin
Overview Seniors
Overview Obesity
Overview Pregnancy
Overview Deficiency
Shut-in category which has
Middle East category which has
22 VitaminDWiki pages had CLOTH in the title as of July 2022
16+ VitaminDWiki pages with SHIFTWORK etc in the title
10 Groups Are More Prone To Vitamin D Deficiency - 2017 - additions include: >age 55, IBD, Vegans, Depression, Headaches
300+ Health problems associated with low vitamin D
This list is in the left-hand column of 15,000+ VitaminDWiki pages
VitaminDwiki – How Much Vitamin D contains
See also
- Optimum category listing has
99 items along with related searches - Toxicity of Vitamin D category listing has
108 items along with related searches - Calcium category listing has
229 items along with related searches - Increased use of D category listing has
55 items along with related searches - Consensus Vitamin D category listing has
73 items along with related searches
VitaminDWiki – Water-dispersible forms of vitamins A, D, E and K are better
For best results, many supplements should be taken in water-dispersible forms
such as: all of the fat soluble vitamins, Omega-3, Resveratrol, Glutathione, etc.
1) More bioavailable (see below: +10% to +50%)
2) Not need to take the supplement with a fatty meal
3) Gets the supplement into the bloodstream without the ~12-hour delay of the Lymph System
topical forms, such as Vitamin D nano-emulsions, are even faster
4) Water-soluble form of vitamins are needed for some health problems
5) Water-dispersible forms are more gut-friendly -see below
Vitamin D evidence: many adults need at least 2,000 IU (more is better) - Jan 2025(Cached) Printer Friendly Follow this page for updates2032 visitors, last modified 15 Jan, 2025, This page is in the following categories (# of items in each category) - Toxicity of Vitamin D category listing has