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Bone Mineral Density and Vitamin D - many studies

55+ VitaminDWiki pages with BONE MINERAL DENSITY or BONE LOSS in the title

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Items found: 55
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50,000 IU of Vitamin D weekly greatly decreased bone loss from prostate cancer therapy - RCT March 2024 24 Mar, 2024
Bone loss reduced in women by vitamin D supplementation - Meta-analysis Jan 2024 15 Jan, 2024
Vitamin D during pregnancy increased child’s bone mineral density – meta-analysis April 2023 27 Apr, 2023
Bone Mineral Density and Vitamin D - many studies 13 Apr, 2023
Transgender associated with autism, low vitamin D, low BMD, etc. - many studies 05 Apr, 2023
Bone mineral density improvement by Vitamin D plus fluoride is augmented by laser acupuncture – RCT March 2023 22 Mar, 2023
Perhaps higher risk of fracture if low BMD plus low vitamin D – July 2022 08 Jul, 2022
Exercise improves bone strength (good), but not bone mineral density (can be measured) – RCT Oct 2021 08 Oct, 2021
Bone loss results in blood vessel plaque if low Vitamin K2, less bone loss if high K2– April 2021 26 Apr, 2021
Vitamin D levels increased, Bone Density Loss decreased (Tasmania) – March 2021 30 Mar, 2021
Giving vitamin D stopped bone loss, stopping vitamin D let the bone loss continue – RCT – Feb 2021 28 Feb, 2021
Bone Mineral Density increased by Resveratrol (which activates the Vitamin D Receptor) – RCT Nov 2020 17 Feb, 2021
Low bone mineral density is inversely associated with both Vitamin D and Resistin (resistance to insulin) 15 Jan, 2021
Bone fractures 1.8 X more likely if hearing loss (which is associated with low vitamin D) – Nov 2019 14 Nov, 2019
Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 2019 07 Sep, 2019
Less bone loss if take 100,000 IU vitamin D monthly – RCT Nov 2017 07 Jul, 2019
COPD results in bone loss and osteopenia, Vitamin D should reduce both – May 2019 16 May, 2019
Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018 29 Apr, 2019
Drug-induced bone loss: a major safety concern (Vitamin D can help) – Sept 2018 18 Sep, 2018
Postmenopausal women need Vitamin D, protein and exercise to prevent loss of muscle and bone – Aug 2018 21 Aug, 2018
Bone loss during black pregnancies – 4000 IU of vitamin D was not enough – Dec 2017 12 Dec, 2017
Bone loss stopped by monthly 12,000 IU of vitamin D – RCT June 2016 07 Nov, 2017
Bone loss (following gastric cancer) reduced by 16,000 IU of vitamin D every 10 days – Aug 2017 03 Aug, 2017
IoM error: 8 percent, not just 1 percent, had bone loss when vitamin D higher than 20 ng 09 May, 2017
Bone mineral density somewhat better with 3750 IU vs 600 IU Vitamin D (1 year, with Calcium) – RCT March 2017 10 Mar, 2017
Low bone mineral density of male children is associated with low BMD of parents – Oct 2016 18 Oct, 2016
Bone loss not stopped by monthly 48,000 IU of vitamin D – RCT June 2016 14 Jun, 2016
Osteoporosis vitamin D workshop - but still test BMD first - Oct 2010 19 Jan, 2016
Weight loss increased Vitamin D levels, which improved bones and decreased inflammation – Oct 2015 18 Aug, 2015
800 IU Vitamin D proven again to not be enough to stop bone loss - Aug 2015 03 Aug, 2015
Hypothesis: Extensive burns reduce vitamin D, which increase bone loss – Nov 2012 31 May, 2015
Bone strength (more accurate than BMD) is inversely associated with vitamin D level – May 2015 30 May, 2015
Long bone fracture – prediction by low vitamin D is better than low BMD – Sept 2014 16 May, 2015
Hypothesis: increased bone mineral density needs protein, Ca, Mg, Vitamin D and K 28 Oct, 2014
Increasing bone mineral density increases breast cancer by at least 2X – Aug 2012 26 Oct, 2014
600,000 IU intramuscular D3 helped BMD after pancreatic surgery – June 2010 24 Jan, 2014
BMD associated with free and bioavailable vitamin D – March 2011 06 Jan, 2014
Low vitamin D, not low BMD, associated with both breaking hip and upper body bone in a fall – Oct 2013 05 Nov, 2013
Acute Multiple Sclerosis relapse associated with low bone mineral density (low vitamin D) – Oct 2013 12 Oct, 2013
Vitamin K2 from natto improved bone mineral density – March 2011 11 Oct, 2013
Both Vitamin D and Calcium are needed to reduce bone loss – RCT Sept 2013 29 Sep, 2013
Working other than dayshift reduces vitamin D levels and Bone Mineral Density and increases bone pain – Aug 2013 22 Aug, 2013
Low vitamin D associated with 5.5X increased risk of low bone mineral density – March 2013 22 Aug, 2013
Hip bone loss stopped with 1000 IU of vitamin D, while 400 IU similar to placebo – RCT April 2013 17 Aug, 2013
Vitamin D intervention stopped bone loss in those mice getting too much alcohol – Aug 2012 31 Jul, 2013
Hypothesis: Not vitamin D deficient if have normal PTH and BMD – May 2013 01 Jun, 2013
HIV patients had bone loss and less than 20 ng of vitamin D – Sept 2010 26 Oct, 2012
Vitamin D did not increase BMD among some ballet dancers – March 2012 28 Mar, 2012
Vegans had lower vitamin D – similar fracture rate - less bone loss – Aug 2011 04 Aug, 2011
9 minutes a day of sun improved BMD Parkinsons disease patients – Jan 2011 01 Jun, 2011
Reduced vitamin D and BMD and Neurological Conditions – April 2011 05 May, 2011
BMD improved with 800 mg Calcium, 400 IU of vitamin D, and 100 ug of vitamin K – April 2011 04 Apr, 2011
2800 IU vitamin D daily did not decrease bone loss for those with MS – March 2011 31 Mar, 2011
Even 400 IU reduced bone loss a bit – Aug 2010 21 Aug, 2010
Low BMD among teaching doctors in India - July 2010 09 Jul, 2010

Meta-analysis of Vitamin D and Bone Mineral Density - April 2023

Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis
Nutr Rev . 2023 Apr 11;81(5):511-530. doi: 10.1093/nutrit/nuac068 behind publisher paywall
Elham Kazemian 1, Ali Pourali 2, Fatemeh Sedaghat 3, Mehrdad Karimi 4, Vahid Basirat 5, Zohreh Sajadi Hezaveh 6 7, Sayed Hossein Davoodi 7, Michael F Holick 8

Image
Context: There is still controversy over the effect of vitamin D3 supplementation on bone health.

Objective: The effects of vitamin D3 supplementation on bone mineral density (BMD) and markers of bone turnover, as well as the dose-response relationship between vitamin D3 and bone health in adults, were evaluated.

Data sources: The PubMed, Scopus, Cochrane, Web of Science, and AGRIS databases were searched for articles published through April 30, 2022. Thirty-nine of the 6409 records identified met the inclusion criteria.

Data extraction: Data were extracted from articles by 2 authors, and data extraction was cross-checked independently. A random-effects model was used to estimate the pooled effect size and the associated 95%CI for the effect of vitamin D3 for each outcome. A one-stage random-effects dose-response model was used to estimate the dose-response relationship between vitamin D3 supplementation and BMD.

Data analysis: Results of meta-analysis showed a beneficial effect of vitamin D3 at the

  • lumbar spine (standardized mean difference [SMD] = 0.06; 95%CI, 0.01-0.12) and
  • femoral neck (SMD = 0.25; 95%CI, 0.09-0.41).

Dose-response analysis revealed a linear relationship between vitamin D3 supplementation doses and

  • BMD at the femoral neck,
  • lumbar spine, and
  • total hip sites.

No significant effect of vitamin D3 supplementation on whole-body or total hip BMD was observed (P > 0.05). Vitamin D3 supplementation significantly decreased BMD at both proximal and distal forearm (SMD = -0.16; 95%CI, -0.26 to -0.06). The variables of ethnicity, age, baseline 25-hydroxyvitamin D (25[OH]D), menopause status, vitamin D3 dosing frequency, and bone health status (P interaction = 0.02) altered the effect of vitamin D3 supplementation on BMD. Additionally, a nonlinear relationship between vitamin D3 supplement doses and markers of bone turnover was found.

Conclusion: A protective effect of vitamin D3 supplementation on BMD of the lumbar spine, femoral neck, and total hip is implicated.

Accelerated bone loss in late reproductive-aged and perimenopausal women with vitamin D insufficiency – Sept 2024

Journal of Bone and Mineral Metabolism PDF behind paywall
Min-Jeong Kim, Sunmie Kim, Jin Ju Kim & Kyung Hee Han

Introduction
The association between serum vitamin D levels and bone mineral density (BMD) varies by race and gender. This study aimed to evaluate this relationship between serum vitamin D levels and BMD, and changes of BMD over time in Korean women.

Materials and methods
We analyzed data from 586 generally healthy Korean women aged 29–79 who underwent health check-ups at Seoul National University Gangnam Center between 2010 and 2011 (baseline measurement) and 2015–2016 (follow-up). Dual energy X-ray absorptiometry (DEXA) and serum 25-hydroxyvitamin D (25OH-D) level measurements were conducted. We assessed the association between serum 25OH-D levels and BMD, as well as changes in BMD over time.

Results
The mean age of participants was 51.3 ± 7.9 years, with a mean follow-up interval of 4.6 ± 0.7 years, and mean serum 25OH-D level of 20.6 ± 8.5 ng/ml. Baseline serum 25OH-D levels did not correlate with BMD values at the lumbar spine, femoral neck, or total femur, nor with changes in BMD over time. A significant negative association was found between perimenopausal status and BMD changes at all sites, and between premenopausal status and lumbar bone mass, compared to postmenopausal status in the 25OH-D < 20 ng/ml group. This association was not observed in women with higher serum 25OH-D levels.

Conclusions
Serum 25OH-D levels did not correlate with BMD levels or changes in BMD overall. However, in late reproductive-aged and perimenopausal women with serum 25OH-D insufficiency, there was a significant association with accelerated bone loss.

VitaminDWiki – Bone - Health category contains

311 items in Bone - Health category
See also

VitaminDWiki – Overview Osteoporosis and vitamin D contains

  • FACT: Bones need Calcium (this has been known for a very long time)
  • FACT: Vitamin D improves Calcium bioavailability (3X ?)
  • FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
  • FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
  • FACT: Vitamin D supplements are very low cost
  • FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
  • FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
  • FACT: Co-factors help build bones.
  • FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
  • It appears that to TREAT Osteoporosis:
  •        Calcium OR vitamin D is ok
  •        Calcium + vitamin D is good
  •        Calcium + vitamin D + other co-factors is great
  •        Low-cost Vitamin D Receptor activators sometimes may be helpful
  • CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
  • Category Osteoporosis has 219 items
  • Category Bone Health has 311 items

Note: Osteoporosis causes bones to become fragile and prone to fracture
  Osteoarthritis is a disease where damage occurs to the joints at the end of the bones

VitaminDWiki - 32 studies in both categories Bone AND Osteoporosis

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Bone Mineral Density and Vitamin D - many studies        
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