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Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021

Asthma exacerbations in children reduced 2.4X (59%) by 1600 IU of vitamin D daily – 10 study meta-analysis Dec 2024

Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials
Ann Med. 2024 Dec;56(1):2400313. doi: 10.1080/07853890.2024.2400313
Katherine Fedora 1 2, Retno Asih Setyoningrum 1 2, Qorri' Aina 1, Laili Nur Rosyidah 1, Nur Lailatun Ni'mah 3, Feelin Fatwa Titiharja 4

Background: Observational studies have linked low vitamin D (VD) levels to increased asthma attacks in children. Subsequent meta-analyses of adults and children revealed that VD treatment might benefit asthmatic patients by reducing the incidence of exacerbations. Therefore, this review aims to analyze the effects of VD supplementation in reducing asthma exacerbations in children.

Methods: Published reports from PubMed, Cochrane, and Google Scholar were systematically searched until April 2023. The study protocol was registered in the PROSPERO database CRD42023411796. Randomized controlled trial studies were included in this review. Meta-analysis was performed using Cochrane RevMan 5.1 and presented with 95% confidence intervals (CIs).

Results: Ten relevant studies enrolled 1243 asthmatic children (631 children receiving vitamin D3 supplementation, 612 children receiving placebo) were included in this review. Our pooled analysis found that VD supplementation had a significant effect on lowering the total number of asthma exacerbations (RR 0.62; 95% CI: 0.44, 0.87; p = 0.01).
Subgroup analysis revealed that a daily dose of VD given based on standard daily dose recommendation had a significant improvement on asthma exacerbations [(RR 0.41; 95% CI: 0,18, 0,92; p = 0.03).

Conclusions: Vitamin D supplementation can lower the occurrence of exacerbations in children with asthma, along with the improvement of FEV1.
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Vitamin D and asthma occurrence in children: A systematic review and meta-analysis - Aug 2021

Journal of Pediatric Nursing, https://doi.org/10.1016/j.pedn.2021.07.005 PDF costs $14.

VitaminDWiki

Note: 3X average reduction for trials giving
200, 200, 600, 650, 1,000, 1,000, 1,200, 2,000 IU daily   for as little as 6 weeks
   Should have given > 1,500 IU daily for at least 24 weeks

Problem
The association between serum 25-Hydroxyvitamin D (25-OHD) level and asthma occurrence in children was controversial.

Eligibility criteria
The Pubmed, Ovid Medline, Embase, Cochrane Library were systematically searched up to April 13th 2020. All the study measured the serum 25-OHD level in children, or classified the children based on the 25-OHD level into severe vitamin D deficiency, insufficient deficiency and comparing the prevalence of asthma in childhood were included in our study.

Sample
A total of 35 studies were included in our meta-analysis. Among them, 24 studies were included for analyzing the association between 25-OHD level and asthma, and 12 studies evaluated the treatment effect of vitamin D.

Results
The children with asthma (5711 participants) had significant lower 25-OHD level than children without asthma (21,561 participants) (21.7 ng/ml versus 26.5 ng/ml, SMD = −1.36, 95% = −2.40 - - 0.32, P = 0.010).
Besides, the children with asthma treated with vitamin D supplement had a significantly lower recurrence rate than the placebo group (18.4% versus 35.9%, RR = 0.35, 95%CI = 0.35–0.79, P = 0.002).

Conclusions
Children with asthma had a lower 25-OHD level than healthy children.
Vitamin D supplement could decrease the asthma recurrence rate in the follow-up years.

Implications
This study implies that lower 25-OHD may cause asthma in childhood.

Overview Asthma and Vitamin D contains

The worse the bronchial asthma, the lower the vitamin D – Jan 2017
click on the chart to see the study

162+ VitaminDWiki pages contain ASTHMA... in the title

Items found: 164
Title Modified
Resulting childhood Asthma cut in half if 4,400 IU Vitamin D daily while pregnant - RCT April 2023 07 Oct, 2024
Newly diagnosed Asthma increased 13% if COVID vaccination (200,000 US children) – Sept 2024 03 Oct, 2024
Major reduction allergies and asthma if the child was born in a sunny season (in Paris in this case) – April 2024 20 Apr, 2024
Possible asthma bio-markers (miRNA) which show risk vs vitamin D level – March 2024 12 Mar, 2024
Obese asthmatic children Vitamin D - 50,000 IU then 8,000 IU daily - RCT Jan 2024 24 Jan, 2024
Overview Asthma and Vitamin D 24 Jan, 2024
Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 21 Dec, 2023
Less Asthma if mother took vitamin D while pregnant – Oct 2023 14 Dec, 2023
Vitamin D half life is shorter in asthmatic children who are more obese – Nov 2023 24 Oct, 2023
The more severe the Asthma, the lower the vitamin D level - Oct 2023 12 Oct, 2023
Children who are overweight or asthmatic need more Vitamin D – Aug 2023 06 Sep, 2023
Severe asthmatics willing to pay 5180 dollars for relief, Vitamin D needed costs only 45 dollars – Sept 2023 13 Aug, 2023
Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021 24 Jul, 2023
Prevention of allergies, eczema, asthma, in children – Vitamin D during pregnancy is a principal solution – July 2023 21 Jul, 2023
Asthma probably fought by Vitamin D in more than 4 ways – review May 2023 13 Jun, 2023
Asthma exacerbations cut in half by Vitamin D when not taking corticosteroids - Cochrane – Feb 2023 06 Feb, 2023
CDC funded study: 1.3 X Asthma risk if vaccination contained aluminum – Sept 2022 29 Sep, 2022
Mild to moderate persistent asthma cost-effectively treated by Vitamin D – Aug 2022 03 Aug, 2022
Asthma: some aspects reduced by Vitamin D – July 2022 26 Jul, 2022
Unethical to restrict Vitamin D to half of the asthmatic children in RCT – June 2018 25 Jul, 2022
Asthma treated by Vitamin D - 13th Meta-analysis – July 2022 10 Jul, 2022
Asthma has been treated by 40 ng of vitamin D, but not this time – meta-analysis June 2022 05 Jul, 2022
2X increase risk of Asthma if a particular Vitamin D Receptor mutation – meta-analysis Feb 2022 04 Jul, 2022
The Sun is the best remedy for Your Lungs (Infection, Asthma and COPD) - video June 2022 27 Jun, 2022
Wheezing and asthmatic children have weaker Vitamin D responses - May 2022 19 May, 2022
Vitamin D reduces RTI, Omega-3 reduces wheezing or asthma – March 2022 11 Apr, 2022
Asthma, Fractures, Prostate Cancer, Lupus, etc associated with low Vitamin D – umbrella review Nov 2021 11 Jan, 2022
Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021 04 Aug, 2021
Asthma reduced by Vitamin D, even for those using corticosteroids - meta-analysis 2021 03 Aug, 2021
Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019 01 Jul, 2021
Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021 28 Jun, 2021
Asthmatics with more Zinc breath better – Dec 2020 03 Mar, 2021
Asthma treated by monthly 100,000 IU of Vitamin D if person had very low levels – RCT Feb 2021 06 Feb, 2021
Small vitamin D doses given during pregnancy do not reduce childhood asthma – meta-analysis Dec 2020 12 Dec, 2020
Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017 25 Jul, 2020
Those with Asthma or COPD had half the response to Vitamin D – March 2020 19 Mar, 2020
Antibiotics increased the risk of asthma by 47%, and allergies by 25% - Dec 2019 31 Dec, 2019
Asthma worse if lower Vitamin D – Dec 2019 10 Dec, 2019
Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019 26 Nov, 2019
Asthmatics less able to breathe if low vitamin D – meta-analysis Nov 2019 14 Nov, 2019
Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019 07 Nov, 2019
Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019 23 Oct, 2019
Asthma more closely associated with poor VDBP gene than with poor Vitamin D level – June 2014 15 Oct, 2019
Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019 17 Sep, 2019
Interactions of Asthma Vitamin D, Pollution and Obesity – July 2019 07 Jul, 2019
Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019 22 Jun, 2019
Childhood Asthma risk greatly reduced if mothers were given 4,400 IU Vitamin D daily – RCT 2019 20 Jun, 2019
Asthma is poorly controlled if have 4 ng less Vitamin D – April 2019 25 May, 2019
Asthma supplementation by Vitamin D (any amount) reduced attacks by 25 percent – meta-analysis April 2019 11 May, 2019
Perhaps reduce asthma exacerbations with Vitamin D – April 2019 28 Apr, 2019
Not all Vitamin D levels follow the season – Asthma, Rhinitis, … – March 2019 31 Mar, 2019
Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017 12 Mar, 2019
Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019 12 Mar, 2019
Asthma 3X more likely if have Multiple Sclerosis (both have low Vitamin D) – March 2019 08 Mar, 2019
Vitamin D every 14 weeks is not often enough (asthma in this case)– Feb 2019 21 Feb, 2019
Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018 08 Jan, 2019
Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune... 145 slides- 2017 30 Dec, 2018
Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018 22 Nov, 2018
Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018 03 Nov, 2018
Asthma risk reduced by 67 percent with Vitamin D supplementation if level was initially low– meta-analysis Nov 2017 01 Aug, 2018
All asthma problems reduced after 1 year of Vitamin D – Nov 2017 10 Jul, 2018
Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune, etc – slides May 2017 02 Jul, 2018
More lung capacity (bronchial asthma, FEV1) associated with higher vitamin D – July 2013 01 Jul, 2018
Asthma treated by daily 50,000 IU of Vitamin D – April 2018 24 Jun, 2018
Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018 24 Jun, 2018
Indoor pollution is a problem with obese black asthmatic children – May 2018 08 May, 2018
Both parents smoke – child’s vitamin D level was 30 percent lower and worse asthma – May 2018 26 Apr, 2018
Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018 02 Apr, 2018
Asthma 7 percent less likely for every 40 IU increase in (early) maternal diet – Feb 2018 23 Feb, 2018
Cesarean (associated with low Vitamin D) increased asthma, obesity, miscarriage and stillbirth – meta-analysis Jan 2018 26 Jan, 2018
Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010 10 Jan, 2018
Pregnant women with low vitamin D (e.g. asthmatics) were more likely to have infants with vitamin D problems (asthmatics) – Jan 2018 08 Jan, 2018
Lots of sugar while pregnant doubles asthma risk – 2017 08 Dec, 2017
Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017 18 Jul, 2017
Decreased vitamin D in children taking asthma drugs - April 2010 18 Jul, 2017
Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014 18 Jul, 2017
Acetaminophen (Tylenol) increases asthma 13 Jun, 2017
Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017 02 May, 2017
Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015 15 Jan, 2017
Asthma exacerbations in children decrease by 60 percent with vitamin D supplementation – meta-analysis – 2015 15 Jan, 2017
The worse the bronchial asthma, the lower the vitamin D – Jan 2017 11 Jan, 2017
Severity of adult asthma associated with less vitamin D – Feb 2013 08 Jan, 2017
Asthma not helped by less than 2,000 IU of vitamin D - meta-analysis Aug 2015 08 Jan, 2017
3 X increased chance of death if have asthma – study of 200,000 people over 10 years – Nov 2012 04 Jan, 2017
Asthma reduced 31 percent when Omega-3 taken during pregnancy – RCT Dec 2016 29 Dec, 2016
Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016 21 Dec, 2016
Childhood allergy, asthma and eczema associated with repeated low vitamin D tests – Oct 2016 16 Dec, 2016
Vitamin D during pregnancy reduces risk of childhood asthma by 13 percent – meta-analysis Dec 2016 16 Dec, 2016
Asthma medicines not helped by vitamin D (if only a small amount of D is taken) – meta-analysis Dec 2015 10 Dec, 2016
Asthma in 3 year olds decreased somewhat with 4,000 IU during pregnancy – RCT Jan 2016 02 Dec, 2016
Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016 12 Nov, 2016
Asthma severe when both Vitamin D AND Magnesium are low – Oct 2016 08 Nov, 2016
Why deficiencies in vitamin D and magnesium are linked to asthma 08 Nov, 2016
Vitamin D supplements could halve risk of serious asthma attacks – Cochrane conclusion – Sept 2016 04 Oct, 2016
40 Asthma US clinical trials (give vitamin D and see what happens) - August 2016 24 Aug, 2016
Allergies and asthma – overwhelming experimental evidence that vitamin D helps – more studies needed – Dec 2014 03 Aug, 2016
Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016 03 Aug, 2016
Childhood asthma trial stopped – decided unethical to not give Vitamin D to all – Feb 2016 03 Aug, 2016
Still unsure of association between vitamin D and asthma and allergies – review April 2012 17 Jun, 2016
Asthmatic pregnant women had 30 percent more preterm births if air pollution (vitamin D not mentioned) – March 2016 09 Mar, 2016
5X fewer school days missed due to asthma if take 2,000 IU vitamin D daily – RCT Feb 2016 05 Feb, 2016
Asthma trial underway - 4,000 IU during pregnancy - March 2014 27 Jan, 2016
Asthma associated with low vitamin D, independent of allergic status – Nov 2015 25 Nov, 2015
Asthma exacerbations with colds reduced by 40 percent with vitamin D supplementation – Nov 2015 25 Nov, 2015
Asthma 2X less likely in those with high vitamin D – Sept 2015 19 Nov, 2015
Asthma at age 20 increased if vitamin D during pregnancy was higher than 50 ng – Oct 2015 04 Nov, 2015
Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014 22 Oct, 2015
Asthma with COPD has lower vitamin D levels than asthma alone – Sept 2015 25 Sep, 2015
Severe asthma children 31X more likely to develop chronic obstructive lung disease -May 2010 25 Sep, 2015
2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 09 Sep, 2015
Vitamin D, Vitamin A, or Vitamin E association with allergies and asthma – Feb 2012 22 Aug, 2015
Asthma attacks associated with low vitamin D– systematic review April 2015 10 May, 2015
Asthma not reduced by taking vitamin D every 60 days (no surprise) – RCT Feb 2015 13 Apr, 2015
Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015 04 Mar, 2015
Vitamin D reduces asthma - Jan 2012 25 Jan, 2015
Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015 06 Jan, 2015
Asthma problems decreased following vitamin D supplementation (amount unstated) – Sept 2014 26 Dec, 2014
Strong Vitamin D deficiency associations in Asthma patients – Nov 2014 18 Nov, 2014
Bronchial Asthma reduced with 60,000 IU monthly vitamin D – RCT Nov 2013 14 Sep, 2014
Asthma attacks (exacerbations) 25 percent more likely in adults if low vitamin D – Aug 2014 19 Aug, 2014
Severe asthma strongly associated with low vitamin D – Sept 2011 19 Aug, 2014
Asthma reduced by weekly 50,000 IU of vitamin D – RCT Aug 2014 03 Aug, 2014
Children with severe asthma had much lower levels of vitamin D – Dec 2011 02 Jul, 2014
Asthma is not treated by weekly 14,000 IU of vitamin D (proven yet again) July 2014 02 Jul, 2014
Asthma related to vitamin D by 4 plausible genes – Nov 2013 26 Jun, 2014
Asthma strongly associated with modification in vitamin D genes 26 Jun, 2014
Vitamin D Deficiency is a Strong Predictor (4X) of Asthma in Children – Oct 2012 27 May, 2014
Asthma damage might be prevented by Vitamin D – April 2014 15 Apr, 2014
Asthma much worse in city with little vitamin D – March 2014 27 Mar, 2014
Asthma is strongly associated with low vitamin D (but not COPD) – meta-analysis Feb 2014 17 Mar, 2014
Asthma in 6 year old boys was 3X more likely if low vitamin D during early gestation – March 2014 10 Mar, 2014
Lung, lung cancer, asthma, COPD, and Vitamin D – July 2013 22 Feb, 2014
Asthma strongly related to vitamin D deficiency in Turkey – Dec 2013 21 Dec, 2013
Nanoemulsions of vitamin D help reduce asthma markers in mice– Dec 2013 12 Dec, 2013
Just 700 IU of vitamin D during pregnancy reduced rate of asthma at age 7 by 26 percent – Oct 2013 05 Nov, 2013
Women with asthma 35X more likely to be vitamin D deficient – Oct 2013 26 Oct, 2013
Should Vitamin D Supplementation Be a Regular Part of Asthma Care – Oct 2013 06 Oct, 2013
Vitamin D might be able to deal with severe asthma – Sept 2013 06 Oct, 2013
Synergy between Vitamin D and corticosteroids in asthma – editorial April 2013 30 Sep, 2013
Asthma Solved Naturally (book) 25 Aug, 2013
How Vitamin D reduces asthma – 2011 07 Feb, 2013
No association between low level of vitamin D and severity of Asthma – Nov 2010 20 Nov, 2012
Severity of difficult asthma not proportional to vitamin D levels – Nov 2012 20 Nov, 2012
Low Vitamin D associated with asthma - 2010 13 Nov, 2012
Vitamin D Genes associated with Childhood Asthma And Lung Function - April 2012 10 Nov, 2012
Vitamin D and asthma – Review June 2012 18 Aug, 2012
Asthmatic corticosteroid treatment – get the least improvement if low vitamin D – July 2012 12 Aug, 2012
Smoking while pregnant lowers vitamin D and increases child asthma by 3.6 X – Aug 2011 20 Jul, 2012
Sun exposure protects children from asthma – May 2011 25 Jun, 2012
Crescendo of papers on Asthma, Allergy, and Vitamin D – Sept 2011 11 Jun, 2012
Severe adult asthma strongly associated with low vitamin D - April 2012 11 May, 2012
Vitamin D deficiency is prevalent among asthmatic African-Americans – Aug 2010 17 Mar, 2012
Vitamin D in asthma and allergy – editorial Dec 2011 05 Dec, 2011
Children with low vitamin D were 4.8X more likely to get asthma – Oct 2011 21 Oct, 2011
Asthma worse with low Vitamin D only at age 4 - cohort study Sept 2011 28 Sep, 2011
The Role of Vitamin D in Asthma – Mar 2010 14 Aug, 2011
Are microbs – probiotics – vitamin D – allergy – asthma – obesity related – Mar 2011 20 Jul, 2011
Asthma Eczema and Vitamin D - Council Newsletter Oct 2010 18 Jul, 2011
Low vitamin D for 6 year old boys predicted asthma at age 14 – May 2011 15 May, 2011
Asthma should be reduced by vitamin D – literature review Sept 2010 14 Jan, 2011
Many possible associations of increased asthma in black children – Nov 2010 26 Nov, 2010
800 IU Vitamin D while pregnant decrease child asthma by 2X- Sept 2010 02 Sep, 2010
Review of vitamin D asthma and allergic diseases – abstract lacks details July 2010 20 Aug, 2010
Corticosteroid decreased vitamin D levels in children with asthma – April 2010 07 Jul, 2010
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Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021        
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