Vitamin D injection is far better than oral for diabetics (poor gut) – RCT

Created March 2017

:: See also similar studies at the bottom of this page ::

Guesses of Vitamin D response if poor gut

**
Bio Form Speed Duration
10 Injection ($$$)
or Calcidiol or Calcitriol		 D - Slow
C -Fast		 Long
10 Sun/UVB Slow Long
10 Topical
(skin patch/cream, vagina)		 Slow
Fast nano		 Normal
9 Nanoemulsion -mucosal
perhaps activates VDR		 Fast Normal
9? Inhaled (future) Fast Normal
8 Bio-D-Mulsion Forte Normal Normal
6 Water soluble (Bio-Tech) Normal Normal
4 Sublingual/spray
(some goes into gut)		 Fast Normal
3 Coconut oil based Slow Normal
2 Food (salmon etc.) Slow Normal
2 Olive oil based (majority) Slow Normal **

10= best bioavailable, 0 = worst, guesses have a range of +-2

Speed: Fast ~2-6 hours, Slow ~10-30 hours

Duration: Long ~3-6 months, Normal = ~2 months

Poor gut is associated with Gut diseases as well as Diabetes, Multiple Sclerosis, and many other diseases

Reminder - Vitamin D is absorbed in the first portion of the small intestine

Some gut problems which only occur in large intestine may not be a problem

On-going research at VitaminDWiki as of March 2017

   Getting Vitamin D into your blood and cells has details on each thype of vitamin D and the following chart

image

Parenteral vitamin D supplementation is superior to oral in vitamin D insufficient patients with type 2 diabetes mellitus

Diabetes & Metabolic Syndrome: Clinical Research & Reviews. online 6 March 2017, http://dx.doi.org/10.1016/j.dsx.2017.03.019

Awanindra Dwivedia, Balram Guptaa, Shalbha Tiwaria, d, Daliparthy D. Pratyusha, d, Saurabh Singhc, Surya Kumar Singha, sksendocrine@yahoo.com

Almost 2X higher vitamin D level @ 30 days with injection * * Injection category listing has items along with related searches** * Overview Gut and vitamin D * Gut-Friendly forms of vitamin D include bio-emulsion, topical, injection * Inhaled vitamin D might be as good as injected (future) Items in both of the categories Diabetes and VitaminD Injection are listed here: {category}

Background/objectives

Oral vitamin D supplementation is better than parenteral in improving vitamin D deficiency in individuals with no systemic illness. Our aim was to compare the efficacy of oral and parenteral routes of vitamin D supplementation on circulating serum 25(OH) vitamin D level in patients with type 2 diabetes mellitus.

Methods

Total 85 cases of with type 2 diabetes mellitus were screened for vitamin D status of which 71 patients were vitamin D insufficient/deficient. They were randomized into two intent to treat groups with different vitamin D supplementation protocols

  • (a) Oral-60000 IU per day for 5 days (group I; n = 40) and

  • (b) injectable-300000 IU intramuscularly once (group II; n = 31).

Baseline and one-month post supplementation 25(OH) vitamin D levels were measured in both the groups.

Results

Baseline clinical characteristics and 25(OH) vitamin D levels were comparable in both the groups. Post treatment 25(OH) vitamin D level in

  • group I was 26.06 ± 9.06 ng/ml and in

  • group II was 49.69 ± 18.92 ng/ml.

After one month of vitamin D supplementation, increment in 25(OH) vitamin D level from baseline was significantly higher in group II than group I (p < 0.001).

Interpretation & conclusions

Injectable method of supplementation was better than oral route in improving serum 25 (OH) vitamin D status in patients with type 2 diabetes. The study suggested impaired absorption of vitamin D from the gastrointestinal tract in patients with type 2 diabetes mellitus and a need for parenteral route of vitamin D supplementation in deficient patients with type 2 diabetes mellitus.

Publisher wants $31.50 for the PDF

Purchased by VitaminDWiki

Injection references in the study

Bone Mineral Density - oral vs injection -Oct 2015

COMPARISON OF ORAL AND INJECTABLE VITAMIN D ON BONE MINERAL DENSITY IN PERI AND POSTMENOPAUSAL WOMEN WITH HYPOVITAMINOSIS D

  • Full text online. 10 weeks of 60,000 IU vs 1 600,000 IU injection + daily 1 gram of Calcium

    • "Although, with intramuscular route the serum vitamin D levels are maintained for 12 months, there is no improvement in BMD byeither route."
    • Sufficiency (> 30 ng) at 12 month:s 85.7% injection, 22.9%. oral
    • image

    Short URL = is.gd/BioForms

Tags: Diabetes Injection Intervention Loading dose