Vitamin D Animal Laboratory - more twins if more vitamin D (sheep)

Created December 2018

VitDal Scotland

YouTube Video- last 40 minutes has some vitamin D items

More Twins if more vitamin D

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More Protein-Losing Enteropathy (PLE) if lower vitamin D

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* Overview Veterinary and vitamin D * Vitamin D increased Phosphorus absorption (chickens) – RCT Oct 2018 * Critically ill dogs with good levels of vitamin D have much better outcomes (humans too) – March 2018 * Half of dogs now get cancer, it used to be just 1 percent (probably low Vitamin D) * More surviving offspring if mother had high vitamin D (sheep in this case) – Jan 2016 * Heavier offspring if mothers had more sunlight (sheep in this case) – Feb 2019 Fertility and Vitamin D * Fertility and sperm * Birth rates doubled with Vitamin D - 300,000 IU for infertile men – RCT Nov 2017 * Ensure a healthy pregnancy and baby - take Vitamin D before conception * Wonder if adding Vitamin D before conception would increase the rate of twins in humans

Key recent achievements of the VitDAL include:

  • Identification of novel relationship between vitamin D status and reproductive fitness in wild sheep

  • Identification that vitamin D status predicts mortality in hospitalised cats and in dogs with chronic enteropathies

  • Discovering a negative relationship between vitamin D status and inflammation in dogs and cats

  • Establishing that 1,25(OH)2D3 can block active, but not passive, experimental autoimmune encephalomyelitis, a widely used murine model of multiple sclerosis

  • Discovering that 1,25(OH)2D3 can dramatically influence the expression of co-stimulatory molecules, cytokine production and migratory behaviour of dendritic cells

  • Identification that sheep with dark coats have lower 25(OH)D3, but not 25(OH)D2

  • Discovering a novel syndrome of marked hypovitaminosis D in dogs with a protein losing enteropathy

  • Demonstrating that dogs with atopic dermatitis and low vitamin D have poorer clinical responses to glucocorticoid therapy than vitamin D replete dogs

Some of his/their recent publications – a few of which are Vitamin D

  • 129) Hudson, N.P.H., Rhind, S.M., Mellanby , R.J., Giannopoulos, G.M., Dalziel, L. and Shaw, D.J. (2018) Success at Veterinary School: Evaluating the Influence of Intake Variables on Year 1 Examination Performance. Journal of Veterinary Medical Education

  • 128) Brehany, C. Hamilton, J., Mellanby , R.J. and Gow, A.G. (2018) The effect of ammonia on canine polymorphonuclear cells. Veterinary Research Communications

  • 127) Gibson, A.D, Lohr F., Mayer D., Bailey J., Mazeri S., Wallace R., Handel, I., Shervell, K., Bronsvoort, M., Mellanby R.J.* and Gamble, L.* (2018) One million dog vaccinations recorded on mHealth innovation used to direct teams in numerous rabies control campaigns. PLoS ONE (*joint senior authors)

  • 126) Oosthuyzen, W, ten Berg, P, Francis, B, Campbell, S, Macklin, V, Milne, E, Gow, A, Fisher, C, Mellanby , RJ and Dear, J. (2018) The development of a reference interval for circulating microRNA-122 in healthy dogs demonstrates sensitive and specific diagnostic accuracy for liver disease. Journal of Veterinary Internal Medicine

  • 125) Mellanby , RJ, Scott, J, Mair, I, Fernandez, A, Saul, L, Arlt, A Moral, M and Vendrell, M. (2018) Tricarbocyanine N-triazoles: The Scaffold-of-Choice for Long-Term Near-Infrared Imaging of Immune Cells in vivo. Chemical Science

  • 124) EL Rayner, I Otter, A Susheelan, RJ. Mellanby RJ, Meunier NV, Gibson A and Gamble L. (2018) Prevalence of mutilations and other skin wounds in working donkeys in Tamil Nadu, India. Veterinary Record

  • 123) Airikkala-Otter I, Gamble L, Handel IG, Bronsvoort BMC, Mellanby RJ, Meunier NV. (2018) Investigation of short-term surgical complications in a low-resource, high-volume dog sterilisation clinic in India. BMC Vet Res. 27;14(1), 56.

  • 122) Bailey, J., Gamble, L., Gibson, A., Bronsvoort, M., Handel, I, Mellanby R.J.* Mazeri, S. (2018) A Rabies Lesson Improves Rabies Knowledge Amongst Primary School Children in Zomba, Malawi. PLoS Neglected Diseases (joint senior author) 12(3):e0006293

  • 121) Cartwright, J., Gow, A., Milne, E., Drummond, D., Smith, S., Handel, I., Mellanby , R.J. (2018) Vitamin D receptor expression in the dog. Journal of Veterinary Internal Medicine. 32, 764-774

  • 120) Mazeri, S., Gibson, A., Bronsvoort, M., Handel, I, Mellanby R.J.* Gamble, L.* (2018) Barriers of attendance to dog rabies static point vaccination clinics in Blantyre, Malawi PLoS Neglected Diseases (*joint senior author) 12(1):e0006159.

  • 119) Ferreira, M., Aylor, A., Mellanby , R.J., Campbell, S., Gow, A.G. (2017) Investigation of manganese homeostasis in dogs with anaemia and chronic enteropathy. Open Veterinary Journal. 7, 360-366

  • 118) Corripio-Miyar, Y., Mellanby , R.J., Morrison, K. and McNeilly, T.N. (2017) 1,25-dihydroxyvitamin D3 modulates the phenotype and function of monocyte derived dendritic cells in cattle. BMC Veterinary Research. 13, 390

  • 117) Stewart, J., Main, Z and Mellanby , R.J. (2017) Successful treatment of acute, severe hypophosphataemia in a dog. Veterinary Record Case Reports. 5, e000460.

  • 116) Marchant TW, Johnson EJ, McTeir L, Johnson C, Gow AG, Liuti T, Kuehn D, Svenson K, Bermingham ML, Drögemüller M, Nussbaumer M, Davey M, Argyle DJ, Powell RM, Guilherme S, Lang J, Ter Haar G, Leeb T, Schwarz T, Mellanby R.J., Clements D.N and Schoenebeck J.J (in press) Canine Brachycephaly is Associated with a Retrotransposon-Mediated Missplicing of SMOC2. Current Biology

  • 115) Rautenbach Y, Goddard A, Thompson P, Mellanby R.J. and Leisewitz A. (in press) A flow cytometric assessment of the lymphocyte immunophenotypes in dogs naturally infected with Babesia rossi. Veterinary Parasitology

  • 114) Saul, L., Besusso, D., Mellanby , R.J. (2017) CD11c+ bone marrow derived dendritic cells can initiate autoimmunity with minimal injection site inflammation. Laboratory Animals. 51, 292-300

  • 113) Titmarsh, H., Kilpatrick, S., Sinclair, J., Lalor, S., Berry, J., Gunn-Moore, D., Reed, N., Handel, I., Mellanby , R.J. (2016). The relationship between vitamin D and leukocytes in hospitalised cats. Journal of Feline Medicine and Surgery. 19, 364-369

  • 112) Meehan, L., Hodgkiss-Geere, H., Walsh, B., Mellanby , R.J. Schwarz, T. (2016) Concurrent physitis and portosystemic shunts in three dogs. Veterinary Record Case Reports. 4 (1) e000316

  • 111) Gibson AD, Handel IG, Shervell K, Roux T, Mayer D, Muyila S, Maruwo GB, Nkhulungo EM, Foster RA, Chikungwa P, Chimera B, Bronsvoort BM, Mellanby RJ, Gamble L. (2016) The vaccination of 35,000 dogs in 20 days using combined static point and door-to-door methods in Blantyre, Malawi. PLOS Neglected Disease. 10(7):e0004824 (joint senior author)

  • 110) Mellanby , R.J. (2016) Beyond the skeleton : a review of the role of vitamin D in companion animal health. Journal of Small Animal Practice. 57, 175-180

  • 109) Handel, I., Watt, K.A., Pilkington, J.G., Pemberton, J.M., Macrae, A., McNeilly, T.N., Berry, J., Clements, D.N., Nussey, D.H. and Mellanby , R.J. (2016) Vitamin D status predicts reproductive fitness in a wild sheep population. Scientific Reports. 6:18986.

  • 108) Kilpatrick, S. Mellanby , R.J. (2016) Systemic Inflammatory Reponse Syndrome predicts poor clinical outcome in dogs with primary hepatitis. PLOS ONE.11(1): e0146560

  • 107) Bessuso, D., Saul, L., Leech, M, O’Connor, R., Macdonald, A., Anderton, S.M., Mellanby , R.J. (2015) 1,25-dihydroxyvitamin D3 conditioned CD11c+ dendritic cells are effective initiators of CNS autoimmunity. Frontiers in Immunology. 6: 575.

  • 106) Gibson, A., Ohal, P., Shervell, K.,Handel, I., Bronsvoort, M., Mellanby , R.J. and Gamble. L. (2015) Vaccinate-assess-move method of mass canine rabies vaccination utilising mobile technology data collection in Ranchi, India. BMC Infectious Diseases. 15(1):589

  • 105) Titmarsh, H., Gow, A.G., Kilpatrick, S., Sinclair, J., Milne, E., Philbey, A., Berry, J., Handel, I., Mellanby , R.J. (2015) Low vitamin D status is associated with systemic and gastrointestinal inflammation in dogs with a chronic enteropathy. PLOS ONE. 10(9): e0137377

  • 104) Hudson, N., Stansbie, N., Rhind, S., Brown G., Handel, I., Mellanby , R.J., and Bell, C. (2015) Recognising and developing students as teachers: Introduction of a novel Undergraduate Certificate in Veterinary Medical Education. Medical Teacher.16, 1-3

  • 103) Titmarsh, H., Lalor, S., Mellanby , R.J. (2015) Vitamin D status in cats infected with feline immunodeficiency virus. Veterinary Medicine and Science. 1, 72-78

  • 102) Titmarsh, H., Gow, A.G., Kilpatrick, S., Sinclair, J., Milne, E., Philbey, A., Berry, J., Handel, I., Mellanby , R.J. (2015) Association of vitamin D status and clinical outcome in dogs with a chronic enteropathy. Journal of Veterinary Internal Medicine. 29, 1473-8

  • 101) Titmarsh, H., Kilpatrick, S., Sinclair, J., Boag, A., Bode, E.F., Lalor, S., Berry, J., Gunn-Moore, D., Reed, N., Handel, I., Mellanby , R.J. (2015). Vitamin D status predicts all-cause mortality in cats. PLoS ONE. 10(9):e0137377

  • 100) Gow, A.G., Frowde, P., Elwood, C., Burton, C., Powell, R., Tappin S.W., Foale, R., Duncan, A., Mellanby , R.J. (2015) Surgical attenuation of spontaneous congenital portosystemic shunts in dogs resolves hepatic encephalopathy but not hypermanganesemia. Metabolic Brain Diseases. 30, 1285-9

  • 99) Sinclair, J., Gow, D., Handel, I., Brown, A., Cash, R., Foote, A., Bell, R., MacKenize, D. and Mellanby , R.J. (2015) Serum cTnI concentrations decrease following treatment of primary immune mediated haemolytic anaemia. Journal of Small Animal Practice. 56, 516-20

  • 98) Tivers, M.S., Handel, I., Gow, A.G., Lipscomb, V.J., Jalan, R. and Mellanby R.J. (2015) Attenuation of congenital portosystemic shunt reduces inflammation in dogs. PLoS ONE 10(2): e0117557

  • 97) Bruno, E.A., Guthrie, G.W., Ellwood, S.A., Mellanby , R.J. and Clements D.N. (2015) Global positioning system derived performance measures are responsive indicators of physical activity, disease and the success of clinical treatments in domestic dogs. PLoS ONE 10(2): e0117094

  • 96) Kilpatrick, S., Gow, A.G., Evans, H. and Mellanby , R.J. (2015) Adrenocorticotrophic hormone causes an increase in cortisol, but not parathyroid hormone, in dogs. Research in Veterinary Sciences. 98,13-5

  • 95) Summers, K.M., Ogden, R., Clements, D.N., French, A.T., Gow, A.G., Powell, R., Corcoran, B., Mellanby , R.J. and Schoeman J.P. (2014) Limited genetic divergence between popular dog breeds from geographically isolated countries. The Veterinary Record. 175, 562

  • 94) Frowde, P., Gow, A., Burton, C., Powell, R., Lipscomb, V., House, A., Mellanby , R.J. Tivers, M. (2014) Investigation of hepatic hepcidin gene expression in dogs with a congenital portosystemic shunt. Journal of Veterinary Internal Medicine. 28, 1203-5

  • 93) Lalor, S., Reed, N., Cash, R., Foot, A., Gunn-Moore, D. and Mellanby , R.J. (2014) Serum cardiac troponin I concentrations are increased in cats with anaemia. Journal of Small Anmal Practice. 55, 320-2

  • 92) Kilpatrick, S., Jacinto, A., Foale, R.D., Tappin, S.W., Burton, C., Frowde, P.E., Powell, R., Duncan, A., Mellanby , R.J. Gow, A.G. (2014) Whole blood manganese concentrations in dogs with primary hepatitis. Journal of Small Animal Practice. 55, 320-2

  • 91) Lalor, S., Schwartz, A.M., Titmarsh, H., Reed, N., Tasker, S., Boland, L., Berry, J., Gunn-Moore, D. and Mellanby , R.J. (2014). Cats with inflammatory bowel disease and intestinal small cell lymphoma have low serum concentrations of 25-hydroxyvitamin D. Journal of Veterinary Internal Medicine. 28, 351-5

  • 90) Kilpatrick, S., Gow, A.G., Foale R.D., Tappin, S.W., Carruthers, H., Reed, N., Yool, D.A., Woods, S., Marques, A.I., Jalan, R. and Mellanby , R.J. (2014) Plasma cytokine concentrations in dogs with congenital portosystemic shunt. Veterinary Journal. 200, 197-9

  • 89) Tivers M.S., Handel I., Gow, A.G., Lipscomb V.J., Jalan R. and Mellanby R.J. (2014) Hyperammonemia and systemic inflammatory response syndrome predicts presence of hepatic encephalopathy in dogs with congenital portosystemic shunts. PLoS ONE. 9, e82303

  • 88) Haastert, B., Mellanby , R.J., Anderton, S.M. and O’Connor, R.A. (2013) T cells at the site of autoimmune inflammation show increased potential for trogocytosis. PLoS ONE. 8, e81404

  • 87) Vazquez-Romero, A, Kielland, N., Arevalo, M., Preciado, S., Mellanby , R.J. Feng, Y, Lavilla, R., Vendrell, M. (2013) Multicomponent Reactions for de Novo Synthesis of BODIPY Probes: in vivo Imaging of Phagocytic Macrophages. Journal of American Chemical Society.135, 16018-21

  • 86) Crawford, K., Warman, S., Marques, A., Yool, D., Eckersal, D., Mellanby , R.J., Gow, A.G. (2013) Haptoglobin concentrations in dogs with liver disease. Veterinary Record. 173, 579

  • 85) Hudson, N.P.H., Rhind, S.M., Shaw, D.J., Giannopoulos, G.M., Bell, C.E., Pearson, G.T., Phillips, C.A. and Mellanby , R.J. (2013) The influence of interview on the selection of students into a veterinary medicine degree programme. Veterinary Record. 173, 368

  • 84) Jacinto, A.,Bommer, N., Chandler, M., Fairbanks, L., Mellanby , R.J. and Gow, A.G. (2013) Urine concentrations of xanthine, hypoxanthine and uric acid in UK Cavalier King Charles Spaniels. Journal of Small Animal Practice. 54, 395-8

  • 83) Rosa, C., Schoeman, J.P., Berry, J. Mellanby , R.J. Dvir, E. (2013) Hypovitaminosis D in canine spirocercosis. Journal of Veterinary Internal Medicine. 27, 1159-64

  • 82) Pickles, K., Rhind, S. and Mellanby , R.J. (2013) Provision of support services for veterinary students in the UK. Veterinary Record. 173, 96

  • 81) Leech, M.D., Barr, T.A., Turner D.G., Brown, S., O’Connor, R.A., Gray, D., Mellanby , R..J. and Anderton, S.M. (2013) Cutting Edge : IL-6 dependent autoimmune disease : dendritic cells as a sufficient, but transient, source. Journal of Immunology. 190, 881-885

  • 80) Mellanby , R.J., Clements, D.N., Ogden, R. , French, A., Gow, A., Powell, R., Corcoran, B., Schoeman, J. Summers, K.M. (2013) Population structure and genetic heterogeneity in popular dog breeds in the United Kingdom. Veterinary Journal. 196, 92-7

  • 79) Clements, D.N., Broadhurst, H., Clarke, S., Farrell, M., Bennett, D., Mosley, J. and Mellanby , R.J. (2013) The Effectiveness of 3D Animations to Enhance Understanding of Cranial Cruciate Ligament Disease. Journal of Veterinary Medical Education. 40, 29-34

  • 78) Mellanby R.J., Cambrook, H., Turner, D., O’Connor R.A., Leech, M.D., Kurschus, F.C., ,MacDonald A.S., Arnold, B. and Anderton S.M. (2012) TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis Journal of Neuroinflammation. 9, 248

  • 77) Kovalik, M., Mellanby , R.J., Berry J., Evans, H., van den Broek A.M. and Thoday K. (2012) Ciclosporin A therapy has minimal impact on calcium metabolism in dogs with atopic dermatitis. Veterinary Dermatology. 23, 481-91

Tags: Veterinary