Overview Cardiovascular and vitamin D

Created February 2011
Many studies show that cardiovascular problems are treated & prevented by Vitamin D    As with many other health problems:    More Vitamin D is needed to treat than to prevent    Omega-3, Magnesium, and Vitamin K2 also probably also help            (More Cardiovascular info below this box) {include}

VitaminDWiki – Cardiovascular category:

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Why Cardio Event RCTs are so difficult to design and analyze

Difficulties in Designing Randomised Controlled Trials of Vitamin D Supplementation for Reducing Acute Cardiovascular Events and in the Analysis of Their Outcomes - July 2020

📄 Download the PDF from VitaminDWiki

studies in both Cardio and Vitamin K categories

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studies in both Cardio and MORTALITY categories

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Mortality and vitamin D (not just Cardio) items

VitaminDWiki – Hypertension category contains

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pages listed in BOTH Hypertension and Cardiovascular categories

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See also STROKES

Items in BOTH of the categories Cardiovascular and Stroke:__

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VitaminDWiki – Metabolic Syndrome contains

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Items in BOTH of the categories Cardiovascular and Metabolic Syndrome

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See also web

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MAYO Clinic April 2012: Pathways from vitamin D Deficiency to CVD

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RCT found no increase in physical performance in heart failure patients with 50,000 IU weekly - Feb 2013

A randomized controlled trial of high dose vitamin D3 in patients with heart failure.

JACC Heart Fail. 2013 Feb;1(1):84-90. doi: 10.1016/j.jchf.2012.11.003.

Boxer RS1, Kenny AM2, Schmotzer BJ3, Vest M4, Fiutem JJ5, Piña IL6.

OBJECTIVE: To investigate the effect of Vitamin D3 on physical performance in patients with HF.

BACKGROUND: HF is associated with functional decline and frailty. Vitamin D deficiency is associated with loss of muscle strength and poor outcomes in patients with HF.

METHODS: Sixty-four patients participated in a 6-month parallel design double blind RCT to test the hypothesis that oral vitamin D3 would improve physical performance. Vitamin D3 50,000 IU or placebo was given weekly; all received daily calcium. Patients were included regardless of EF and 25OHD ≤ 37.5 ng/ml. The primary outcome was peak VO2, and secondary outcomes were the 6MW, TGUG and knee isokinetic muscle strength. Between group comparisons were made using ANCOVA models that adjust for baseline measures.

RESULTS: Patients were age 65.9 ± 10.4 years old, 48% women, 64% African American, EF 37.6±13.9, 36% NYHA III, the remainder NYHA II.

At baseline the vitamin D group 25OHD was 19.1 ± 9.3 ng/ml and increased to 61.7 ± 20.3 ng/ml; in the placebo group baseline 25OHD was 17.8 ± 9.0 ng/ml and decreased to 17.4 ± 9.8 ng/ml at 6 months (between groups p<0.001).

There was no significant change from baseline to 6 months in peak VO2, 6MW, TGUG or isokinetic muscle strength.

CONCLUSIONS: Vitamin D3 did not improve physical performance for patients with HF despite a robust increase in serum 25OHD. Vitamin D repletion in patients with HF should conform to standard adult guidelines for vitamin D supplementation.

📄 Download the PDF from VitaminDWiki.

Seems like the study did things correctly. Good amount of vitamin D, trial lasted long enough, vitamin D levels were raised high enough. Perhaps no improvement in physical performance shouldd be expected AFTER damage was done.

INTERVENTION Clinical Trials for (heart OR cardiovascular) and "vitamin D" 538 as of Sept 2024

  • Intervention = give vitamin D and see what happens usually testing vitamin D vs placebo

  • The majority of these intervention trials are for TREATMENT, rather than prevention

  • Vitamin D and cardiovascular disease preventiom May 2016

    • Large Ongoing Random Controlled CVD trials
    • No apparent attempt to trial those with low levels of vitamin D,
      No Magnesium added,
      No Omega-3 added,
      Not much vitamin D used - especially since statins used with CVD reduce the vitamin D
      No Vitamin K2 to stop Calcium increased by Vitamin D from coating the arteries
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99+ proofs that Vitamin D works (includes some CVD)

Proof that Vitamin D Works has the following Cardio related proofs

Health Problem Treat
Prevent		 Reduction__
    click for details		 RCT = Random Controlled Trial
   ✻ = link to additional RCT
CT = Clinical Trial		 Vitamin
DWiki
  #
Hypertension T 149 to 142 mm Hg RCT ✻  ✻ , 2400 IU.  100,000 IU* 1
Cardiovascular after attack T 32 % fewer deaths CT 1000 IU 2
Diabetes T2 T 62 % RCT ✻ ✻ , CRP reduction, 4000 IU 4
Congestive Heart Failure T [Tiki-index. PHP? page_id=2441] RCT, 1000 IU infants ([Tiki-index. PHP? page_id=4138]) 27
After Heart Attack T [Tiki-index. PHP? page_id=4695] RCT, 800,000 IU one time 34

Increased exercise after heart attack cuts in half the chance of death in next four years

  • Mercola May 2018
    • Back in the 1960's you were supposed to have 6 weeks of bedrest following a heart attack
    • Mercola does not mention that exercise might greatly reduce the risk of the heart attack as well

See also: Omega-3

studies in both Cardio and Omega-3 categories

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Items in BOTH of the categories Cardiovascular and Magnesium

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Items in BOTH of the categories Cardiovascular and Women

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31+ VitaminDWiki Cardiovascular pages have RCT in the title

The list is automatically updated

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Short url = http://bit.ly/Zczfrw

Tags: Cardiovascular Overview