Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis
Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials
Nutrients 2022, 14(3), 679; https://doi.org/10.3390/nu14030679
by Nicola Veronese 1ORCID,Damiano Pizzol 2ORCID,Lee Smith 3ORCID,Ligia J. Dominguez 1,4,* andMario Barbagallo 1ORCID
Only CRP and NO were signifcantly changed by Mg
60% of trials found that CRP was reduced by Mg
Amount of NO increase - similar for the 3 trials
Magnesium trials: type, duration, and amount
Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23 November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as an outcome. Among 2484 papers initially screened, 17 randomized controlled trials (889 participants; mean age: 46 years; females: 62.5%) were included. Generally, a low risk of bias was present.
In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels . In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1.
In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.
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12+ VitaminDWiki pages with NITRIC OXIDE in the title
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VitaminDWiki pages with CRP in title (8 as of April 2022)
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VitaminDWiki - Inflammation category starts with
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VitaminDWiki - Overview Magnesium and vitamin D venn relationship of Mg and Vit D
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See also: Mg and NO on PubMed
Magnesium causes nitric oxide independent coronary artery vasodilation in humans - 2001 📄 PDF
Effects of magnesium on nitric oxide synthase activity in endothelial cells - 1995 - https://doi.org/10.1152/ajpcell.1995.269.3.C612
Serum Magnesium and Fractional Exhaled Nitric Oxide in Relation to the Severity in Asthma-Chronic Obstructive Pulmonary Disease Overlap - May 2021 https://doi.org/10.1007/s12011-020-02314-5
VitaminDWiki - 30 most-recently changed items in the Magnesium Category
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