Inhaled vitamin D help lungs - many studies

Created November 2016

Inhaled Vitamin D has treated my breathing problems from pollen, forest fire smoke, mold, dust, and my exercise-induced asthma for 8 years now.
It might also help with other breathing problems proven to be helped by oral Vitamin D:
- pneumonia, RTI, Hay Fever, Wheezing, TB, Respiratory Virus, and COPD.
The benefits of 5 seconds of inhaled vitamin D are felt in less than 2 minutes.
- The volume of air inhaled increased by 4 times: 500 ml to 2000 ml as measured by a spirometer $40
Amazingly, only about 500 IUs of inhaled Vitamin D are needed.
Since using inhaled Vitamin D, I only use an Albuterol inhaler a few times per year.
- I had been using Albuterol about 10 times per month.
5 years ago I experimented with 10 inhalers and 5 nanoemulsions - most worked.
- I ended up using Vitamin D Nurasal nanoemulsion $22 and Facial Steamer $7.
I just add 1 part Vitamin D nanoemulsion to 3 parts 0.9% saline solution (add 4.3 grams of salt to 1 pint of distilled water).
I keep the inhaler and extra liquid in the refrigerator to stop mold from otherwise growing in about 2 months.
- Every 4-6 months I rinse the inhaler with tap water and make a tapwater mist for 30 seconds.
- I infrequently wear a $40 mask with a battery powered HEPA filter to clean very dirty air when exercising outdoors.

Founder of VitaminDWiki- Dec 2024

In Oct, 2016 I wondered if Vitamin D could be applied locally to the lungs There are many low-cost ($10-30) nebulizers on Amazon which put a very fine mist with ultrasonics -115KHz) , 0.5 to 5 micrometer

New version in 2017 own 10 inhalers as of June 2019 them in 2018

It might be possible to just put some water-soluble vitamin D powder into water in an atomizer A Vitamin D inhaler/atomizer/nebulizer might be very useful for some kinds of respiratory problems -such as Asthma, Pneumonia, Wheezing, COPD, Respiratory Tract Infections, respiratory allergies, second-hand smoke, . . 3 million molecules of Vitamin D per alveoli (500 million alveoli in lungs, 1.5 trillion molecules in 40 IU of Vit D)

Update Nov 2016: Inhaled Vitamin D water with purchased nebulizer - lungs feel much better in < 1/2 hour. Dec 4: Continue to use it daily. I inhale about 500 IU of vitamin D in 30 seconds Powder of 50,000 IU Vitamin D capsule dissolved in 5 tablespoons of water Pour off or filter the water thru a coffee filter so as to keep the cellulose from clogging the inhaler Update 2018 - switched to using Vitamin D Emulsion 2 parts water to 1 part Vitamin D emulsion ==> inhaler 1 of the sources of Vitamin D emulsion Amazon Update 2019: >10 companies making nebulizers and >10 companies making Vitamin D emulsions Bought several more nebulizers on Amazon Aug 2020 1 2 3 4 Update April 2025: 2 Misters costs a total of $10 Amazon

Surface area of lungs + nose =8X more than the small intestines | | | | --- | --- | | | square meters | | Respiratory | 90 | | Nasal passages which include microvilli | 160 | | Small Intestines - where oral Vitamin D is absorbed | 30 | 1. See also VitaminDWiki * COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015 * Wonder how many days it would take to reduce Asthma or COPD if Vitamin D were inhaled? * Update 2019: A person with severe COPD really liked inhaling Vitamin D * Inhaled Vitamin D 1 page summary March 2019 * Inhaling Vitamin D nanoemulsion through nose gets lots more to the brain (mice) – July 2020 * Perhaps drugs such as inhaled vitamin D can get directly to the brain – March 2018 * Largest cause of infant deaths is respiratory infections, which is associated with low vitamin D – April 2011 * Antimicrobial implications of vitamin D – Oct 2011 * Respiratory infections (RTI) cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015 * Overview Asthma and Vitamin D * Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016 * Inhaled vitamin D helped lungs of new-born (rats) – Dec 2016 * This is the paper which got me thinking about inhaled vitamin D * Lung cells activate Vitamin D, without liver or kidney – Nov 2016 * Vitamin D sprayed inside cheeks (buccal spray) - several studies * Topical vitamin D might be more bio-available than oral – Oct 2015 See also VitaminDWiki - activation outside of the lungs, liver-kidneys * Vaginal Vitamin D reduced vaginal infections - Jan 2014 another local application * Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016 * The eyes can also activate vitamin D – Feb 2014 * PhD Dissertation - Local production of active vitamin D inhibits Prostate Cancer – Oct 2012 * Kidney not essential for Vitamin D3 activation – fungi can do it – Jan 2014 * Bones can activate vitamin D – July 2013 * Mitochondria Vitamin D interaction – many studies * Eczema (Atopic Dermatitis) treated by 1600 IU of vitamin D – meta-analysis Dec 2016 * Itchy skin (pruritus) due to kidney disease was treated with topical vitamin D – April 2015 * Topical Vitamin D Emulsions on VitaminDWiki * Nanoemulsion Vitamin D may be a substantially better form --- 1. Breathing category starts with the following {include} --- 1. Vitamin D can be converted to an activated form in most cell tissues; no gut, liver, or kidney are needed

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VITAMIN D EFFECTS ON LUNG IMMUNITY AND RESPIRATORY DISEASES - 2011

Vitam Horm. 2011 ; 86: 217-237. doi:10.1016/B978-0-12-386960-9.00009-5.

Sif Hansdottir, MD, MS and Martha M. Monick, Ph.D.

Dept of Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242

📄 Download the PDF from VitaminDWiki

SUMMARY

Our understanding of vitamin D metabolism and biological effects has grown exponentially in recent years and it has become clear that vitamin D has extensive immunomodulatory effects.

The active vitamin D generating enzyme, 1a-hydroxylase, is expressed by the airway epithelium, alveolar macrophages, dendritic cells and lymphocytes indicating that active vitamin D can be produced locally within the lungs.

Vitamin D generated in tissues is responsible for many of the immunomodulatory actions of vitamin D .

The effects of vitamin D within the lungs include increased secretion of the antimicrobial peptide cathelicidin, decreased chemokine production, inhibition of dendritic cell activation and alteration of T cell activation. These cellular effects are important for host responses against infection and the development of allergic lung diseases like asthma. Epidemiological studies do suggest that vitamin D deficiency predisposes to viral respiratory tract infections and mycobacterial infections and that vitamin D may play a role in the development and treatment of asthma. Randomized, placebo controlled trials are lacking but ongoing.

Section from the PDF

III. 1,25-DIHYDROXYVITAMIN D IS GENERATED LOCALLY IN THE LUNGS

Humans get vitamin D through synthesis in the skin following UVB exposure and to a lesser extent from limited dietary sources. Vitamin D from the skin or diet is metabolized primarily in the liver to 25-hydroxyvitamin D3 (25D) (Ponchon, Kennan et al. 1969). 25Dis the “storage form” of vitamin D and is used to determine the vitamin D status of individuals.

The last and rate limiting step in the synthesis of “active” 1,25-dihydroxyvitamin D3 (1,25D) is catalyzed by the mitochondrial enzyme 1a-hydroxylase and is conventionally known to take place in the kidneys. Renal 1a-hydroxylase activity is under stringent regulation by parathyroid hormone, calcium, calcitonin, phosphorus and 1,25D itself (ZEHNDER, BLAND et al. 1999). Vitamin D is inactivated by the ubiquitous enzyme, 24- hydroxylase, whose expression is inducible by 1,25D, thus creating a negative feedback loop (Holick 2007). The biological effects of vitamin D are achieved through the regulation of gene expression mediated by the vitamin D receptor (VDR) (Baker, McDonnell et al. 1988). Active vitamin D binds to VDR and upon ligand binding, the receptor dimerizes with the retinoic X receptor (RXR) (MacDonald, Dowd et al. 1993). The VDR/RXR complex binds to vitamin D responsive elements (VDREs) within the promoter regions of vitamin D regulated genes (Sutton and MacDonald 2003).

It is increasingly recognized that localized synthesis of 1,25D rather than systemic production is responsible for many of the immune effects of vitamin D . Extra-renal expression of 1a-hydroxylase has been found in various cells of the immune system including alveolar macrophages (Adams, Sharma et al. 1983; Reichel, Koeffler et al. 1987), dendritic cells (Fritsche, Mondal et al. 2003; Hewison, Freeman et al. 2003; Sigmundsdottir, Pan et al. 2007) and lymphocytes (Chen, Sims et al. 2007; Sigmundsdottir, Pan et al. 2007) as well as in airway epithelia (Hansdottir, Monick et al. 2008) (Table 1). Locally formed 1,25D acts in an autocrine or paracrine fashion to modulate cell proliferation, cell differentiation and immune function (Bell 1998; Hewison, Burke et al. 2007; White 2008).

Intranasal emulsions (Vitamin D in the future?)

in VitaminDWiki Nasal Vitamin B12 treatment for children (perhaps nasal Vitamin D too) – Nov 2019
C. V. Pardeshi and V. S. Belgamwar, “Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood-brain barrier: An excellent platform for brain targeting,” Expert Opinion on Drug Delivery, vol. 10, no. 7, pp. 957–972, 2013.
W.-Y. Ong, S.-M. Shalini, and L. Costantino, “Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders,” Current Medicinal Chemistry, vol. 21, no. 37, pp. 4247–4256, 2014.
L. Illum, “Nasal drug delivery—possibilities, problems and solutions,” Journal of Controlled Release, vol. 87, no. 1-3, pp. 187–198, 2003.
P. Khadka, J. Ro, H. Kim et al., “Pharmaceutical particle technologies: an approach to improve drug solubility, dissolution and bioavailability,” Asian Journal of Pharmaceutical Sciences, vol. 9, no. 6, pp. 304–316, 2014.
V. Puri, “A study on nano emulsion (Emulgel),” International Journal of Advanced Pharmaceutical Sciences, vol. 1, no. 3, pp. 27–55, 2018

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Inhaled vitamin D help lungs - many studies

VITAMIN D EFFECTS ON LUNG IMMUNITY AND RESPIRATORY DISEASES - 2011

III. 1,25-DIHYDROXYVITAMIN D IS GENERATED LOCALLY IN THE LUNGS

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Intranasal emulsions (Vitamin D in the future?)

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