Infertility - 71 percent of the time of BOTH partners had less than 20 ng of Vitamin D

Concordance of vitamin D peripheral levels in infertile couples' partners.

Gynecol Endocrinol. 2017 Aug;33(8):649-652. doi: 10.1080/09513590.2017.1306737

Paffoni A1, Ferrari S1, Mangiarini A1, Noli S2, Bulfoni A3, Vigano P4, Parazzini F2, Somigliana E1,2.

1 Infertility Unit, Fondazione Ca' Granda, Ospedale Maggiore Policlinico , Milan , Italy.

2 Department of Clinical Sciences and Community Health , Università degli Studi di Milano , Milan , Italy.

3 Department of Obstetrics and Gynaecology , Humanitas Research Hospital , Milan , Italy , and.

4 Division of Genetics and Cell Biology , Reproductive Sciences Laboratory, IRCCS Ospedale San Raffaele , Milan , Italy.

A large number of evidence supports the role of vitamin D insufficiency in both women and men infertility. However, no studies have evaluated the rate of concordance of vitamin D status between the partners. This finding might open new scenarios in the interpretation of the available data linking vitamin D insufficiency and infertility. In the present cross-sectional study, 103 consecutive infertile couples were recruited between April and May 2014. Both partners concomitantly provided a serum sample for the assessment of 25-hydroxy-vitamin D [25-(OH)-D]. Vitamin D insufficiency was defined as serum 25-(OH)-D <20 ng/ml. One hundred-fifty subjects (73 women and 77 males) were 25-(OH)-D insufficient, corresponding to a rate of 73%.

Overall, concordance was observed in 73 couples (71%), thus higher than the expected 61% (0.732 + 0.272) based on chance (p = 0.007).

The Pearson coefficient of correlation R2 between the partners of the couples was 0.52 (p < 0.001). No statistically significant differences emerged when evaluating the rate of 25-(OH)-D insufficiency according to the causes of infertility. Serum 25-(OH)-D correlates within the partners of infertile couples. Further evidence is warranted to determine the clinical relevance and possible clinical applications of this finding.

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See also VitaminDWiki

• Birth rates doubled with Vitamin D - 300,000 IU for infertile men – RCT Nov 2017

• Poor fertility in both women and men associated with low vitamin D – review Feb 2018

• Global sperm count dropped by 59 percent in 40 years – meta-analysis Aug 2017

• Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015

• Vitamin D and Human Reproduction – 51 page chapter – April 2017

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