How vitamin D benefits normal organs and Long-COVID organs

Created December 2024

Comparison of the role of vitamin D in normal organs and those affected by COVID-19

Int J Med Sci 2025; 22(2):240-251. doi:10.7150/ijms.103260

Rajendran Peramaiyan1,2 Corresponding address#, Josephine Anthony3 Corresponding address#, Sureka Varalakshmi3, Ashok Kumar Sekar4, Enas M. Ali1,5, Al Hashedi Sallah A6, Basem M. Abdallah1

1. Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.
2. Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600 077, Tamil Nadu, India
3. Department of Research, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai - 600 078, Tamil Nadu, India.
4. Centre for Biotechnology, Anna University, Chennai-600 025, Tamil Nadu, India.
5. Department of Botany and Microbiology, Faculty of Science, Cairo University, Cairo 12613, Egypt.
6. Central Laboratories, Department of microbiology, King Faisal University, 31982, Al-Ahsa, Kingdom of Saudi Arabia.

: Equal Contribution.

Corresponding authors: Dr. P. Rajendran; Dr. A. Josephine. E-mail: prajendran@kfu.edu.sa; ajosephineanthony@gmail.com.

Benefits to normal organs

Benefits to Long-COVID organs

Benefits to BOTH normal organs and Long-COVID organs

The outbreak of COVID-19 has opened up new avenues for exploring the importance of vitamin D in immunity, in addition to its role in calcium absorption. Recently, vitamin D supplementation has been found to enhance T regulatory lymphocytes, which are reduced in individuals with COVID-19. Increased risk of pneumonia and increases in inflammatory cytokines have been reported to be major threats associated with vitamin-D deficiency. Although vaccination reduces the threat of COVID-19 to a certain extent, herd immunity is the long-term solution to overcoming such diseases. Co-administration of vitamin D with certain inactivated vaccines has been reported to enhance the systemic immune response through stimulation of the production of antigen-specific mucosal immunity.

COVID-19 was found to induce multiple organ damage, and vitamin D has a beneficial role in various organs, such as the

intestines,
pancreas,
prostate,
kidneys,
liver,
heart,
brain, and
immune cells.

The consequences that occur after COVID-19 infection known as long COVID-19 are also a concern as they accumulate and target multiple organs, leading to immune dysregulation.

The present review covers the overall role and impact of vitamin D and its deficiency for various organs in normal conditions and after COVID-19 infection, which is still a serious issue.

📄 Download the PDF from VitaminDWiki

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VitaminDWiki - Long-COVID - many studies contains

VitaminDWiki - COVID protects itself by deactivating the Vitamin D Receptor

COVID virus fails to re-activate the VDR as it leaves: low cellular vitamin D, but not lower blood vitamin D

VitaminDWiki - studies in both categories Virus and Cognition

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VitaminDWiki - studies in both categories Virus and Cardiovascular

This list is automatically updated''

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Tags: Cardiovascular Cognitive Gut Kidney Liver Virus