Diabetic inflammation reduced by Vitamin D – meta-analysis

Created March 2018

Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Nutr Rev. 2018 Feb 27. doi: 10.1093/nutrit/nux077. [Epub ahead of print]

Mousa A1, Naderpoor N1, Teede H1, Scragg R2, de Courten B1.

  • 1 Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

  • 2 School of Population Health, University of Auckland, Auckland, New Zealand.

* Sepsis is both prevented and treated by Vitamin D - many studies * Inflammatory diseases: review of vitamin D, with many tables – May 2014 * Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT Jan 2016 * Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017 * Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT 2014 * Omega-3 improves gut bacteria, reduces inflammation and depression – Dec 2017 * HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017 * The above study was published after the study on this page stopped looking for new data 1. Overview Diabetes and vitamin D contains the following summary {include} --- 1. Diabetes category starts with the following {include} --- * As with virtually all meta-analyses, the amount of vitamin D is not considered. * Note – The study showing the most benefit happens to have used a lot of vitamin D (50,000 IU every 2 weeks: Razzaghi [doi: 10.1016/j.jdiacomp.2016.06.017))](https://doi.org/10.1016/j.jdiacomp.2016.06.017))

📄 Download the PDF from VitaminDWiki

image

BACKGROUND:

Vitamin D has been proposed to have anti-inflammatory properties; however, the effect of vitamin D supplementation on inflammation in type 2 diabetes has not been established.

OBJECTIVE:

The aim of this systematic review and meta-analysis was to examine the effect of vitamin D supplementation on inflammatory markers in patients with type 2 diabetes and to identify relevant gaps in knowledge.

DATA SOURCES:

MEDLINE, CINAHL, Embase, and EBM Reviews were searched systematically from inception to January 25, 2017.

STUDY SELECTION:

Randomized controlled trials (RCTs) investigating the effects of vitamin D supplementation (any form, route, and duration, and with any cosupplementation) compared with placebo or usual care on inflammatory markers in patients with type 2 diabetes were selected.

DATA EXTRACTION:

Study and sample characteristics and aggregate outcome data were extracted, risk of bias was determined, and quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.

RESULTS:

Twenty-eight RCTs were included, 20 of which had data available for pooling. In meta-analyses of 20 RCTs (n = 1270 participants), vitamin D-supplemented groups had lower levels of C-reactive protein (standardized mean difference [SMD] -0.23; 95%CI, -0.37 to -0.09; P = 0.002) and tumor necrosis factor α (SMD -0.49; 95%CI, -0.84 to -0.15; P = 0.005), a lower erythrocyte sedimentation rate (SMD -0.47; 95%CI, -0.89 to -0.05; P = 0.03), and higher levels of leptin (SMD 0.42; 95%CI, 0.04-0.81; P = 0.03) compared with control groups. No differences were observed for adiponectin, interleukin 6, or E-selectin (all P > 0.05). In meta-regression and subgroup analyses, age, sex, body mass index, duration of diabetes, baseline vitamin D status, and dose and duration of supplementation did not alter the results.

CONCLUSIONS:

This meta-analysis provides level 1 evidence that vitamin D supplementation may reduce chronic low-grade inflammation in patients with type 2 diabetes.

SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42016047755. Available at: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=47755 (9/15/2016).

PMID: 29490085 DOI: 10.1093/nutrit/nux077

Tags: Diabetes Inflammation Meta-analysis