Coimbra Protocol (using Vitamin D) is safe and effective for Multiple Sclerosis and Autoimmune diseases
Safety Data in Patients with Autoimmune Diseases during Treatment with High Doses of Vitamin D3 According to the “Coimbra Protocol”
Nutrients 2022, 14(8), 1575; https://doi.org/10.3390/nu14081575
Ulrich Amon 1,*ORCID,Raul Yaguboglu 1,Madeleine Ennis 2, Michael F. Holick 3 ORCID and Julian Amon 1ORCID
1 International Centre for Skin Diseases DermAllegra, Coimbra Protocol Certified Center , Am Markgrafenpark 6, 91224 Pommelsbrunn-Hohenstadt, Germany
2 The Wellcome-Wolfson Institute for Experimental Medicine, Queens University of Belfast, Belfast BT7 1NN, UK
3 Endocrinology, Diabetes, Nutrition & Weight Management, Dept. of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Background: In 2013, the group of Cicero Coimbra, Brazil, reported the clinical efficacy of high doses of vitamin D3 in patients suffering from autoimmune skin disorders (“Coimbra protocol”, CP). However, hypercalcemia and the subsequent impaired renal function may be major concerns raised against this protocol.
Methods: We report for the first time for a broad spectrum of autoimmune diseases in 319 patients (mean age (±SD) 43.3 ± 14.6 years, 65.5% female, 34.5% male) safety data for high doses of orally applied vitamin D3 (treatment period: up to 3.5 years) accompanied by a strict low-calcium diet and regular daily fluid intake of at least 2.5 L.
Results: Mean vitamin D3 dose was 35,291 ± 21,791 IU per day. The measurement of more than 6100 single relevant laboratory parameters showed all mean values (±SD) within the normal range for total serum calcium (2.4 ± 0.1 mmol/L), serum creatinine (0.8 ± 0.2 mg/dL), serum creatinine associated estimated GFR (92.5 ± 17.3 mL/min), serum cystatin C (0.88 ± 0.19 mg/L), serum TSH (1.8 ± 1 mIU/L), and for 24 h urinary calcium secretion (6.9 ± 3.3 mmol/24 h). We found a very weak relationship between the dosage of oral vitamin D3 and the subsequent calcium levels, both in serum and in urinary excretion over 24 h, respectively.
Conclusions: Our data show the reliable safety of the CP in autoimmune patients under appropriate supervision by experienced physicians.
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75% had mutations in the genes encoding the enzymes CYP2R1 and CYP27B1
74% has 4+ mutations in nine different genes
5% had mutations in all genes investigated
Coimbra protocol appears to have not tried 8+ things
Infrequent dosing, perhaps once every 3 days - a good way to get past the VDR
Activation of Vitamin D receptors by Resveratrol and 14 other methods
Glutathione etc, which activate many vitamin D genes
Other forms of Vitamin D – which are more bioavailable – especially if poor gut
The use of probiotics to improve the gut microbiome
Water-soluble Vitamin D, Omega-3 - so that fat is not required concurrently
Loading dose to speedup the treatment by several months
Plant-based Calcium for those who must have Calcium
VitaminDWiki – Overview MS and vitamin D contains
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VitaminDWiki – Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains protocol description__
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VitaminDWiki – Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019
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VitaminDWiki – Psoriasis category contains
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VitaminDWiki – Vitiligo (spotty skin) and Vitamin D, UVB - many studies
VitaminDWiki – Autoimmune category contains
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VitaminDWiki – Comparing High-dose vitamin D therapies has a summary table:
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