Alcoholics have osteoporosis

Prognosis of osteopenia in chronic alcoholics.

Alcohol. 2010 Nov 3.

González-Reimers E, Alvisa-Negrín J, Santolaria-Fernández F, Ros-Vilamajó R, Martín-González MC, Hernández-Betancor I, García-Valdecasas-Campelo E, González-Díaz A.

Servicios de Medicina Interna, Hospital Universitario, Universidad de La Laguna, Ofra s/n, Tenerife, Canary Islands, Spain.

– – – – – – – – - - - - - - - - - - - - - - - - - - - -

Observation by VitaminDWiki

too much alcohol ==> liver failure ==>less vitamin D ==> poor bones

– – – – – – – – - - - - - - - - - - - - - - - - - - - -

Osteoporosis is frequent among alcoholics all by a direct effect of ethanol, malnutrition, and liver failure.

Therefore, it may be related to survival.

The aim of this study was to assess bone mineral density (BMD), bone mineral content, hormonal status, and to determine prognostic value of these parameters in a total of 124 alcoholics followed up for a median period of 57 months. Several bone homeostasis-related hormones were measured in patients and age- and sex-matched controls. Whole-body densitometry was performed by a Hologic QDR-2000 (Waltham, MA) densitometer; nutritional status and liver function were assessed.

Sixty patients underwent a second evaluation 6 months later. Patients showed lower serum insulin-like growth factor-1 (median=58, interquartile range [IQR]=33-135 vs. 135ng/mL, IQR=116-243ng/mL, P<.001), vitamin D (25.5, IQR=18.3-36.8 vs. 79.9pg/mL, IQR=59.2-107.8pg/mL, P<.001), and osteocalcin (2.1, IQR=1.1-4.5 vs. 6.5ng/mL, IQR=4.7-8.7ng/mL, P<.001) than controls, and lower BMD values, and lower Z- and T-scores at right and left legs and arms, thoracic and lumbar spine, pelvis, and right and left ribs. By multiple regression analysis, BMD mainly depends on nutritional parameters and liver function. Kaplan-Meier curves show that subtotal BMD and BMD at both arms and pelvis were significantly related with survival. Patients who had lost total hip BMD after 6 months showed a shorter survival than those who had not, but using Cox's regression, encephalopathy, ascites, and nutritional parameters displaced BMD as prognostic factor. Therefore, osteopenia ensues in chronic alcoholic patients. It mainly depends on poor nutrition and is related to survival, although surpassed in this sense by encephalopathy, ascites, and nutritional parameters. Copyright © 2010 Elsevier Inc. All rights reserved. PMID: 21051177

See also VitaminDWiki

• Overview Liver and vitamin D

• Magnesium and vitamin D Alcohol uses up Magnesium, which is needed for bone strength

• Overview Alcohol and Vitamin D

  Items in both categories Osteoporosis and Liver are listed here:

{category}

See also web

• What People Recovering from Alcoholism Need to Know About Osteoporosis NIH

• High Risk Groups for Poor Vitamin Status includes Alchohol

• Alcohol and Other Factors Affecting Osteoporosis Risk in Women with bone photos - from 2003

• PubMed Aug 2012 581 items – examples follow

• Role of obesity , alcohol and smoking on bone health 2012

• Association of 25-hydroxyvitamin D levels with liver dysfunction and mortality in chronic liver disease – 2012

  • die more quickly if so much alcohol then liver dysfunction and low vitamin D
• Assessing bone status in patients awaiting liver transplantation – 2011 88% had low vitamin D levels