600,000 IU of vitamin D – 42 ng at 3 months for 1 inj, 3 inj, oral monthly, oral weekly

Created January 2018

Comparison Of Different Formulations Of Vitamin D.

J Ayub Med Coll Abbottabad. 2017 Oct-Dec;29(4):650-653.

Fahan Rashid HM1, Syed U1, Ahmad Z2, Chauhdary KK3, Musharraf U3, Kumar S3.

600,000 IU ==> 42 ng/ml in 3 months | | | | | --- | --- | --- | | Form | Dose | Frequency | | Injection | 600,000 IU | once | | Injection | 200,000 IU | 3 times | | Oral | 200,000 IU | 3 times | | Oral | 50,000 IU | 12 times | --- * Injection used if unsure if person will take follow-on doses, or if poor gut and a gut-friendly form is not available * Quick oral loading is needed if vitamin D levels must be restored quickly Faster than 1 month) * Oral can be a single time or spread over a week - if there is no emergency * Study does not appear to indicate how close in time the timal dose was to the VitaminD test * it should be a minimum of 3 days - 10 days is much better to see the average/steady state * 600,000 vitamin D loading doses – good response to both oral and muscular – Oct 2015 * Different than current study - just a single dose given, no second dose * * Injection category listing has items along with related searches** * Large dose of vitamin D (200,000 IU) lasts for less than 90 days – Feb 2015 Poor Gut * Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017 * Osteoporosis 4X more likely if poor gut (probably poor vitamin D absorption) – Aug 2017 Emergencies - fast response required * 540000 IU before ICU raised vitamin D by 25 ng in 2 days – March 2011 * Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019 * Vitamin D injection of 600,000 IU (response by 10 individuals)– Sept 2017 nice chart * Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017 * Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017 * 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015 Overview Loading of vitamin D contains the following {include}

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BACKGROUND:

Vitamin D Deficiency (VDD) is responsible for a wide spectrum of clinical diseases and vitamin D deficiency prevalence is frightening in most parts of the world including Pakistan. Therefore, supplementations of vitamin D are used in the population at high risk for the prevention and the treatment of vitamin D deficiency. Vitamin D supplementation comes in various formulations both oral and intramuscular. Cholecalciferol is the most commonly used preparation which is given through these routes of administration. There is need to study the fact that how much vitamin D levels are raised after administration of these different formulations as this can be a pivotal factor in determining dosage and route of vitamin D3.

METHODS:

This cross-sectional study conducted on 320 cases and compared the efficacy of various Vitamin D3 preparations in raising Vitamin D levels conducted in Department of Endocrinology and Metabolism, Services Hospital, Lahore from February to July, 2016. Blood serum was drawn for vitamin D level in the cases at the time of presentation and after treatment.

RESULTS:

Three hundred & twenty patients were enrolled in study and divided into four groups (A, B, C, D). There was no significant difference between groups (A, B, C, D) in change in vitamin d levels after 3 months of treatment (p-Value 0.446).

CONCLUSIONS:

Different preparations of vitamin D are equally effective in raising vitamin D levels at 12 weeks. However, there is a need to conduct large scale studies to further validate these results.

PMID: 29330997

Tags: Loading dose