54,000 IU of vitamin D daily with no Calcium (1,000 IU per kg: Coimbra protocol)
Resolution of Optic Neuritis and Probable Multiple Sclerosis after Long-Term Ingestion of Very High Doses of Vitamin D3: A Case Report
Neuroimmunology Reports, https://doi.org/10.1016/j.nerep.2024.100224
Nipith Charoenngam 1 2, Michael F. Holick 1
PTH bottomed-out (as expected) in a few months
A 36-year-old male presented with 2 months of left-eye visual disturbance and was diagnosed with optic neuritis due to probable multiple sclerosis (MS). He was advised to undergo periodic ophthalmology follow-up without immunosuppressive treatment. Due to persistent symptoms, he expressed interest in very high-dose vitamin D3 therapy of 54,000 IUs/day (1,000 IUs/kg/day) along with a zero-calcium diet. After starting the therapy, he experienced sustained symptomatic improvement of visual symptoms over 4 years, along with radiological stability of the optic neuritis lesion without developing hypercalcemia. This case supports the potential therapeutic efficacy of very high-dose vitamin D for MS.
📄 Download the PDF from VitaminDWiki
VitaminDWiki - Coimbra high-dose vitamin D protocol - many studies
Note: Coimbra protocol consists of much more than just high vitamin D and no Calcium
VitaminDWiki – Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains protocol description__
{include}
MS updates from Brazil
{include}
VitaminDWiki – Overview MS and vitamin D contains
{include}
VitaminDWiki - Response to Vitamin D - many studies
VitaminDWiki – Comparing High-dose vitamin D therapies contains:
{include}