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Arthritic children have low vitamin D (84 percent of the studies) – May 2018

Vitamin D and juvenile idiopathic arthritis.

Pediatr Rheumatol Online J. 2018 May 16;16(1):34. doi: 10.1186/s12969-018-0250-0.
Finch SL1, Rosenberg AM2, Vatanparast H3.
1 College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
2 Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada.
3 College of Pharmacy & Nutrition and School of Public Health, University of Saskatchewan, 104 Clinic Place, Saskatoon, SK, S7N 2Z4, Canada. vatan.h at usask.ca.

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BACKGROUND:
Vitamin D has been implicated in the pathogenesis of autoimmune diseases. While the roles of vitamin D in other autoimmune diseases have been investigated, less is known about the role of vitamin D in chronic childhood arthritis.

MAIN BODY:
This review summarizes and evaluates evidence relating to 25-hydroxyvitamin D (25(OH)D) and chronic childhood arthritis. A scoping literature review was conducted using Ovid Medline, Ovid Embase, Cumulative Index to Nursing and Allied Health Literature, Web of Science and Scopus. Further, we geo-mapped the results of the studies to identify the patterns of the association between vitamin D and chronic childhood arthritis across the globe. Of 38 studies reporting 25(OH)D concentrations in childhood chronic arthritis, 32 (84.2%) reported that a significant number of children had suboptimal (< 75 nmol/L) status.

CONCLUSION:
The data indicate suboptimal vitamin D status in children with chronic arthritis. Further, the association between low vitamin D and increased arthritis activity follow a north-south geographical gradient.


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10501 Vitamin D and juvenile idiopathic arthritis.pdf admin 08 Sep, 2018 1.45 Mb 1004