Vitamin D generally improves the efficacy of drugs while reducing their adverse effects – Jan 2020

Effects of Vitamin D on drugs: Response and disposal


  • This article firstly reviewed the effects of vitamin D on drugs from the aspects of efficacy and pharmacokinetics
  • The article suggests a general phenomenon that vitamin D Improves the efficacy of drugs and reduces the adverse effects of drugs
  • This article reviewed the effects of vitamin D through drug metabolizing enzymes and drug transporters.

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Vitamin D supplementation and vitamin D deficiency are common in clinical and daily life. Vitamin D not only promotes calcium absorption and immune regulation but also changes drug effects (pharmacodynamics and adverse reactions) and drug disposal in vivo when combined with various commonly used clinical drugs. The extensive physiological effects of vitamin D itself may be the cause of synergism effects or alleviation of adverse reactions, and vitamin D affecting drug in vivo disposal through drug transporters and/or metabolic enzymes may also lead to changes in drug effects. In this paper, the effects of vitamin D combined with commonly used drugs were reviewed from the perspective of drug efficacy and adverse reactions. The effects of vitamin D on drug transport and metabolism were summarized and analyzed. It is hoped that more attention will be paid to vitamin D supplementation and vitamin D deficiency in clinical treatment and drug research and development.

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