- Weight-loss drug found to shrink heart muscle in mice, human cells - Nov 2024
- Perplexity AI Agrees Nov 2024
- What percentage of weight loss from diets is due to muscle loss? Asked Perplexity AI Nov 2024
- VitaminDWiki - Weight loss and Vitamin D - many studies
- "High-dose vitamin D appears to help allocate surplus calories to muscle instead of fat tissue, potentially preserving muscle mass"
- Some weight loss diets also result in bone loss
Weight-loss drug found to shrink heart muscle in mice, human cells - Nov 2024
Perplexity AI Agrees Nov 2024
- First documented in a 2021 clinical trial
- The rate of weight loss significantly impacts muscle loss - faster weight loss typically results in greater muscle mass reduction. This is not unique to GLP-1 medications, as similar proportions of muscle loss are seen with traditional dieting and bariatric surgery
What percentage of weight loss from diets is due to muscle loss? Asked Perplexity AI Nov 2024
The percentage of muscle loss during weight loss varies based on several key factors:
Normal Weight vs Overweight Individuals
In overweight individuals, 20-30% of total weight loss comes from muscle mass. For normal weight individuals, the percentage is higher, with 35% or more of total weight loss coming from muscle tissue 3
Impact of Diet Type
The speed and severity of caloric restriction significantly affects muscle loss:
- Very low-calorie diet (500 calories/day): 18% of initial weight loss is muscle mass
- Standard low-calorie diet (1,250 calories/day): 7.7% of initial weight loss is muscle mass 1
Long-Term Results
Four weeks after completing diets, the muscle loss percentages adjust to:
- Very low-calorie diet: 9.4% of total weight loss
- Standard low-calorie diet: 2.9% of total weight loss 1
Factors Affecting Muscle Loss
The exact percentage varies depending on:
- Speed of weight loss
- Pr otein intake during dieting
- Exercise routine, particularly strength training
- Age and genetics 4
Without proper intervention like strength training and adequate protein intake, sedentary individuals can lose approximately 25% of their weight loss from muscle tissue 2
VitaminDWiki - Weight loss and Vitamin D - many studies
More weight is lost if have a high level of vitamin D - examples
- Weight loss on low-calorie diet: 7 lbs more lost if got lots of Vitamin D – June 2021
- Obese taking 50,000 IU of vitamin D weekly lost more weight (again) – RCT Dec 2019
- 2.3 X more weight loss in those who had low vitamin D levels and took some – Dec 2019
- Obese lost 3X more weight with Vitamin D - July 2018
- Why vitamin D is not advertised for weight loss - it was patented
- Weight loss includes muscle loss unless add vitamin D, whey and leucine – RCT Feb 2015
- Citations of that study include
- Preserving Healthy Muscle during Weight Loss - May 2017- FREE PDF
- Pre-habilitation with exercise and high whey-protein-based meal replacement therapy promotes weight loss and preserve muscle mass before bariatric surgery - Sept 2023 FREE PDF
- Unveiling the potential of a whey protein- and leucine-enriched multi-nutrient formula high in vitamin D3: A scoping review on its role in enhancing body composition, strength, and physical function in sarcopenia - Dec 2024 FREE PDF
"High-dose vitamin D appears to help allocate surplus calories to muscle instead of fat tissue, potentially preserving muscle mass"
Observation by Perplexity AI
Reference
Might taking high-dose Vitamin D with GLP-1 result in less muscle loss?
Some weight loss diets also result in bone loss
Not as much bone is needed when the body weighs less, etc Perplexity AI