How to Get Heart Patients to Take Their Pills? Give Them Just One - New York Times Aug 2022
NYT "The participants also experienced one-third fewer cardiovascular deaths,"
Study: Polypill Strategy in Secondary Cardiovascular Prevention
New England Journal of Medicine DOI: 10.1056/NEJMoa2208275
Results
A total of 2499 patients underwent randomization and were followed for a median of 36 months. A primary-outcome event occurred in 118 of 1237 patients (9.5%) in the polypill group and in 156 of 1229 (12.7%) in the usual-care group (hazard ratio, 0.76; 95% confidence interval [CI], 0.60 to 0.96; P=0.02).
A key secondary-outcome event occurred in 101 patients (8.2%) in the polypill group and in 144 (11.7%) in the usual-care group (hazard ratio, 0.70; 95% CI, 0.54 to 0.90; P=0.005). The results were consistent across prespecified subgroups. Medication adherence as reported by the patients was higher in the polypill group than in the usual-care group. Adverse events were similar between groups.
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- One pill every two weeks gives you all the vitamin D most adults need
- Better than Daily
- Better compliance due to:
- Fewer opportunities to forget
- Fewer times to have to take a pill - for those who dislike it