Overview Rheumatoid Arthritis and vitamin D

FACT: People with Rheumatoid arthritis are often vitamin D deficient
REPORT: People with the most Rheumatoid arthritis pain are the most vitamin D deficient
FACT: Rheumatoid arthritis pain is reduced by vitamin D - sometimes as little as 500 IU
FACT: 24 % more likely to get RA if have consume a low amount of vitamin D

---

---

VitaminDWiki – Rheumatoid Arthritis category contains

121 RA items     See also Overview Rheumatoid Arthritis   Autoimmune  Inflammation   Pain - Chronic

    Highlights of RA studies in VitaminDWiki
RA worse if low Vitamin D

• Rheumatoid Arthritis score extrapolates to zero at 51 ng of Vitamin D (India) – June 2024
• Rheumatoid Arthritis is more severe if low vitamin D – July 2023
• Rheumatoid arthritis pain was 5.8 X more likely if low vitamin D – Aug 2017
• Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019
• Rheumatoid Arthritis strongly associated with low vitamin D – meta-analysis April 2016
• Rheumatoid Arthritis associated with lower vitamin D and higher latitude – meta-analysis Jan 2016

11 RA and Vitamin D Receptor (auto-updated)

RA Treated by Vitamin D

• Several rheumatic diseases treated by high-dose vitamin D, but made worse if Calcium was added – April 2022
• Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
• Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
• Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months – Oct 2015
• Connective tissue disorders (Lupus, RA, etc) treated by vitamin D – May 2016
• 43 percent of Rheumatoid Arthritis patients have Vitamin D prescriptions (15 countries) – June 2017
• Big increase in vitamin D supplementation in just 2 years after Swiss rheumatology report – Dec 2013
• High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015
  • Note: Vitamin D receptor problems (such as RA) are best treated by infrequent large doses of Vitamin D

---

See also at VitaminDWiki

• Rheumatoid Arthritis category 121 items
• Autoimmune and vitamin D 206 items
• Inflammation and vitamin D 176 items
• Pain- Chronic and vitamin D 169 items
• Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months – Oct 2015
• Active Rheumatologic disease was 5X more likely with low vitamin D – June 2013
• Boron and Granulomas (TB, Rheumatoid arthritis, Crohn's, Rheumatic Fever etc.) - 2015
• Rheumatoid arthritis associated with low vitamin D – Fibromyalgia makes it even lower – Oct 2014
• Big increase in vitamin D supplementation in just 2 years after Swiss rheumatology report – Dec 2013
• 100 percent of rheumatoid arthritis patients with very low vitamin D had very severe RA – Jan 2013
• Every patient with rheumatoid arthritis had low vitamin D, severity was proportional to degree of deficiency – June 2014
• High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015
• Overview Osteoarthritis and Vitamin D
• Increased D levels responsible for Dead Sea therapy – May 2011
• Juvenile Rheumatoid Arthritis associated with low vitamin D, but how low – meta-analysis Jan 2013
• 20 percent less Rheumatoid Arthritis if got lots of sunshine – Feb 2013
• Ankylosing spondylitis and low vitamin D – many studies a kind of RA
• Vitamin D and rheumatic diseases. – Review July 2014 has the following chart
  
• RA is the 3rd more prevelant type of Arthritis
  

---

RA people who had Methotrexate Therapy were 28% less likely to die if previously >20 ng of Vitamin D - Jan 2024

Higher Vitamin D Levels before Methotrexate Therapy Initiation Are Associated with Lower Subsequent Mortality in Patients with Rheumatoid Arthritis
Nutrients 2024 Jan 30;16(3):401. doi: 10.3390/nu16030401

Vitamin D deficiency is associated with mortality in the general population and has been observed in one rheumatoid arthritis (RA) cohort. Here, we investigate the relationship between 25-hydroxyvitamin D (25(OH)D) levels before methotrexate (MTX) therapy initiation in patients with RA and the subsequent all-cause mortality in a national Veterans Affairs (VA) cohort. (2) This is a retrospective study on RA patients time-oriented around the initial MTX prescription and 25(OH)D levels before starting MTX. We examined survival in patients with 25(OH)D levels > 50 nmol/L and ≤50 nmol/L using the Cox Proportional Hazard Model and fully adjusted for risk factors. (3) In total, 15,109 RA patients were included in the nationwide cohort. RA patients with 25(OH)D levels > 50 nmol/L before starting MTX had a 28% reduced risk of mortality when compared to those with levels ≤ 50 nmol/L (HR: 0.72, CI: 0.64-0.80, p < 0.001) after adjusting for traditional risk factors. (4) In this national RA cohort receiving standard-of-care MTX, patients with 25(OH)D levels > 50 nmol/L have a lower subsequent mortality when compared to those with 25(OH)D levels ≤ 50 nmol/L. It remains to be determined whether increasing Vitamin D levels in RA patients initially found to be Vitamin D deficient impacts their all-cause mortality.
 Download the PDF from VitaminDWiki

---

9 Meta-analyses of Rheumatoid Arthritis

---

2012 Review of Vitamin D and RA attached at the bottom of this page has the following image

2014 study on Vitamin D and RA is attached at the bottom of this page

---

See also at VitaminDWiki - PAIN 

• Many kinds of pain relieved by vitamin D VitaminDWIki Blog Feb 2012
• CLICK HERE for pain - chronic, including Back pain - 169 items
• Overview: Fibromyalgia or Chronic Fatigue and vitamin D
• Back pain reduced for 95 percent of those who took vitamin D - 2003
  • "only" 95% of the people with back pain were helped with vitamin D 5000 IU or 10000 IU daily
• Discover the pain of Vitamin D Deficiency
• Cod liver oil had been used for RA for several hundred years now Vitamin D was the active ingredient
  Details are in the notes attached to the page
• All items in category Inflammation and Vitamin D 176 items

---

See also web

• Vitamin D and Autoimmune Rheumatic Diseases - 2023 FRE PDF
• Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response - May 2019
  •  Download the PDF from VitaminDWiki
• Lower vitamin D in Saudia Arabia if RA not responding to treatment May 2012
• The Key to Reversing All Autoimmune Diseases - Mercola Aug 2022
  • Rheumatoid Arthritis is reduced when vitamin D levels are 60-70 ng
  • And when Omega-6 (which blocks ((Overview: Omega-3 many benefits include helping vitamin D|Omega-3) )) is reduced
    • Saflower, Sunflower, Grapeseed, Corn, Soybean
• Newer Drugs for Rheumatoid Arthritis All Have Similar Risks — Maybe It’s Time to Go Natural? Mercola Sept 2012
  I have personally treated over 3,000 patients with rheumatoid arthritis in my practice, which is well over 10 times the amount a typical family physician would treat in their entire career
  Latest additions: Naltrexone, Astaxanthin, Probiotics, regular exercise, Vitamin D
  Vitamin D deficiency is strongly associated with the development of RA.
  From my perspective, it is now virtually criminal negligent malpractice to treat a person with RA and not aggressively monitor their vitamin D levels to confirm that they are in a therapeutic range of 50-70 ng/ml.
• Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis Nov 2012
• Vitamin D in rheumatoid arthritis: panacea or placebo? Nov 2012, Full text online
  . . role of vitamin D in mediating various biological processes is well defined, this has not translated into meaningful clinical associations in RA.
• Vitamin D and rheumatoid arthritis Dec 2012, RA had 15 ng, non-RA had 26 ng
  negative correlations between vitamin D and CRP (–0.115) and ESR (−0.18)
• Serum vitamin D level and disease activity in patients with recent onset rheumatoid arthritis Oct 2013
  patients with more active RA have a lower serum vitamin D level
• 46 Million in the U.S. have Arthritis Carolyn Dean July 2014; Sulfur, Magnesium, Boron, Calcium, Zinc, Manganese, Copper. Sulfur, which is found in my ReAline are important. no mention of Vitamin D
• Vitamin D in rheumatoid arthritis—towards clinical application
  NATURE REVIEWS RHEUMATOLOGY - Oct 2015, PDF is available free at Sci-Hub  10.1038/nrrheum.2015.140
• Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint - 2017
   Download the PDF from VitaminDWiki
• A girl with RA who was taking methotrexate was able to stop after being on Coimbra Protocol for 4 months - June 2018
  Note: Protocol typically has a goal of a vitamin D level of 150 ng
  Her doctor had her stop the high vitamin D level, the RA came back 2 months later, she went back on the protocol
  
  click here to see text from Facebook

  Hi everybody I am a french patient (who lives in Italy) with my daughter (12 years old) of the doctor Giordo, for our arthritis, we follow the Coimbra protocol since September 2017, and we already noticed great results!

  My daughter from 4 months does not need anymore to take methotrexate for the first time!!! She took it since she was 4 years old...and each time doctors said us to remove it after 2 months her arthritis came back with pain and inflammation...

  I wrote to Cicero Coimbra to thank him and I told him I want to share my testimony to the french people who don't know his protocol!! and he kindly answered me the day after, glad I want to share his protocol in my country (I don't know why there is no french doctors who follow the coimbra protocol and no french group FB so I thought to create the first FB GROUP for french people in a FRENCH LANGUAGE!) >> "Protocole du Dr.Cicero G.Coimbra (vit D hautes doses) France" (if you want the link I can send you on messenger! Write me here or send me a PM)

  I hope there are FRENCH PEOPLE in this group who are reading me, maybe they want to sign up in the french group where I am the administrator and bring us their testimonies in french language, it would be fantastic!

  I NEED THE TESTIMONIES TO FRENCH PEOPLE IN THE WORLD AND IN FRANCE!

• Interview and transcript: Vitamin D protocol for Autoimmune diseases – Dr. Coimbra 2016 - such as RA

---

Knee Joint with and without Rheumatoid Arthritis

Note: Boron appears to repair and strengthen cartilage