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Vitamin D in inflammatory diseases – Technical Review June 2014

Front. Physiol. 5:244. doi: 10.3389/fphys.2014.00244
Thea K. Wöbke1, Bernd L. Sorg1 and Dieter Steinhilber1*
1Institute of Pharmaceutical Chemistry, Goethe Universitat, Germany
* Correspondence: Dr. Dieter Steinhilber, Goethe Universitat, Institute of Pharmaceutical Chemistry, Max-von-Laue-Str. 9, Frankfurt am Main, 60438, Germany, steinhilber at em.uni-frankfurt.de

Changes in vitamin D serum levels have been associated with inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, atherosclerosis or asthma. Genome- and transcriptome-wide studies indicate that vitamin D signalling modulates many inflammatory responses on several levels. This includes i) the regulation of the expression of genes which generate pro-inflammatory mediators, such as cyclooxygenases or 5-lipoxygenase, ii) the interference with transcription factors, such as NF-kB, which regulate the expression of inflammatory genes and iii) the activation of signalling cascades, such as MAP kinases which mediate inflammatory responses. Vitamin D targets various tissues and cell types, a number of which belong to the immune system, such as monocytes/macrophages, dendritic cells as well as B- and T cells, leading to individual responses of each cell type. One hallmark of these specific vitamin D effects is the cell-type specific regulation of genes involved in the regulation of inflammatory processes and the interplay between vitamin D signalling and other signalling cascades involved in inflammation. An important task in the near future will be the elucidation of the regulatory mechanisms that are involved in the regulation of inflammatory responses by vitamin D on the molecular level by the use of techniques such as chromatin immunoprecipitation (ChIP), ChIP-seq and FAIRE-seq.

Reviewed by:
Martin Hewison, University of California Los Angeles, USA
Martin Tenniswood, University at Albany, USA


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See also VitaminDWiki


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4046 inflammatory diseases.pdf PDF 2014 admin 17 Jun, 2014 12:09 707.34 Kb 841
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