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VitaminDWiki pages with HASHIMOTO'S in title (8 as of Jan 2023)

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Hashimoto's is associated with low Vitamin D - meta-analysis - Dec 2021

Effects of vitamin D on thyroid autoimmunity markers in Hashimoto's thyroiditis: systematic review and meta-analysis
J Int Med Res. 2021 Dec;49(12):3000605211060675. doi: 10.1177/03000605211060675.
Jingwen Zhang 1, Yuting Chen 2, Hongyan Li 1, Hong Li 1


Objective: To perform a meta-analysis of randomized controlled trials to evaluate the efficacy of vitamin D supplementation on thyroid autoimmunity markers in Hashimoto's thyroiditis (HT).

Methods: This meta-analysis included randomized controlled clinical trials identified by a systematic search of electronic databases (PubMed®, MEDLINE®, EMBASE, The Cochrane Library, China National Knowledge Infrastructure) from inception to August 2020. All studies included patients with HT that received vitamin D supplementation irrespective of the doses administered or the duration of treatment. The primary and secondary outcome measures were thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TGAb) titres.

Results: Eight studies (n = 652) were included. There was significant heterogeneity between the studies. Using a random-effect model, vitamin D supplementation reduced TPOAb titre (standardized mean difference SMD: -1.11; 95% confidence interval CI: 1-1.92, -0.29) and TGAb titre (SMD: -1.12; 95% CI: -1.96, -0.28). A subgroup analysis demonstrated that vitamin D supplementation for >3 months resulted in a decrease in TPOAb titre (SMD: -1.66, 95% CI: -2.91, -0.41) but treatment ≤3 months was ineffective. Treatment with vitamin D3 decreased TPOAb titre (SMD: -1.48; 95% CI: -2.53, -0.42) whereas vitamin D did not.

Conclusion: These data suggest that vitamin D reduces autoantibody titre in patients with HT.
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ID Name Comment Uploaded Size Downloads
16701 Treament more than 3 months.jpg admin 07 Dec, 2021 19.25 Kb 1144
16700 H1.jpg admin 07 Dec, 2021 28.52 Kb 1110
16699 Hashimoto’s Meta.pdf admin 07 Dec, 2021 862.90 Kb 430