The association between circulating 25-hydroxyvitamin D and pancreatic cancer: a systematic review and meta-analysis of observational studies
European Journal of Nutrition Volume 63, pages 653–672
behind $40 paywall https://doi.org/10.1007/s00394-023-03302-w and in DeepDyve
Yajing Shen, Junfen Xia, Chuncheng Yi, Tiandong Li, Peng Wang, Liping Dai, Jianxiang Shi, Keyan Wang, Changqing Sun & Hua Ye
Purpose
The relationship between circulating 25-hydroxyvitamin D [25(OH)D] and pancreatic cancer has been well studied but remains unclear. The purpose of this study was to elucidate the association between circulating 25(OH)D and pancreatic cancer by using a meta-analytic approach.
Methods
PubMed, Embase, and Wed of Science databases were searched through October 15, 2022. A random or fixed-effects model was used to estimate the pooled odds ratio (OR), risk ratio (RR), hazard ratio (HR) and their 95% confidence intervals (CIs).
Results
A total of 16 studies including 529,917 participants met the inclusion criteria, of which 10 reported incidence and 6 reported mortality. For the highest versus lowest categories of circulating 25(OH)D, the pooled OR of pancreatic cancer incidence in case–control studies was 0.98 (95% CI 0.69–1.27), and the pooled HRs of pancreatic cancer mortality in cohort and case–control studies were 0.64 (95% CI 0.45–0.82) and 0.78 (95% CI 0.62–0.95), respectively. The leave-one-out sensitivity analyses found no outliers and Galbraith plots indicated no substantial heterogeneity.
Conclusion
Evidence from this meta-analysis suggested that high circulating 25(OH)D levels may be associated with decreased mortality but not incidence of pancreatic cancer. Our findings may provide some clues for the treatment of pancreatic cancer and remind us to be cautious about widespread vitamin D supplementation for the prevention of pancreatic cancer.
VitaminDWiki – Cancer - Pancreatic category contains:
Risk of Pancreatic Cancer significantly reduced by each of:
Vitamin D, Vitamin K, Magnesium, Vitamin D Receptor Activators, and Omega-3
Perhaps the combination would reduce PC risk by >90%
if taken for at least 2, and perhaps 5 years
- Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
- Pancreatic Cancer survival 2.3 X more likely if good level of Vitamin D – meta-analysis Sept 2023
- Pancreatic Cancer is increasing – Vitamin D and Omega-3 should reduce the risk
- Pancreatic Cancer – live a year longer if have high vitamin D and good Vitamin D Receptor – Aug 2018
- People consuming more Vitamin K1 were 40 percent less likely to get Pancreatic Cancer – Oct 2021
- Pancreatic Cancer risk increased 24 percent for every 100 mg less of Magnesium intake – Dec 2015
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