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Overview Rheumatoid Arthritis and vitamin D

FACT: People with Rheumatoid arthritis are often vitamin D deficient
REPORT: People with the most Rheumatoid arthritis pain are the most vitamin D deficient
FACT: Rheumatoid arthritis pain is reduced by vitamin D - sometimes as little as 500 IU
FACT: 24 % more likely to get RA if have consume a low amount of vitamin D



VitaminDWiki – Rheumatoid Arthritis category contains

115 RA items     See also Overview Rheumatoid Arthritis   Autoimmune  Inflammation   Pain - Chronic

    Highlights of RA studies in VitaminDWiki
RA worse if low Vitamin D

10 RA and Vitamin D Receptor (auto-updated)

RA Treated by Vitamin D


See also at VitaminDWiki


RA people who had Methotrexate Therapy were 28% less likely to die if previously >20 ng of Vitamin D - Jan 2024

Higher Vitamin D Levels before Methotrexate Therapy Initiation Are Associated with Lower Subsequent Mortality in Patients with Rheumatoid Arthritis
Nutrients 2024 Jan 30;16(3):401. doi: 10.3390/nu16030401

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Vitamin D deficiency is associated with mortality in the general population and has been observed in one rheumatoid arthritis (RA) cohort. Here, we investigate the relationship between 25-hydroxyvitamin D (25(OH)D) levels before methotrexate (MTX) therapy initiation in patients with RA and the subsequent all-cause mortality in a national Veterans Affairs (VA) cohort. (2) This is a retrospective study on RA patients time-oriented around the initial MTX prescription and 25(OH)D levels before starting MTX. We examined survival in patients with 25(OH)D levels > 50 nmol/L and ≤50 nmol/L using the Cox Proportional Hazard Model and fully adjusted for risk factors. (3) In total, 15,109 RA patients were included in the nationwide cohort. RA patients with 25(OH)D levels > 50 nmol/L before starting MTX had a 28% reduced risk of mortality when compared to those with levels ≤ 50 nmol/L (HR: 0.72, CI: 0.64-0.80, p < 0.001) after adjusting for traditional risk factors. (4) In this national RA cohort receiving standard-of-care MTX, patients with 25(OH)D levels > 50 nmol/L have a lower subsequent mortality when compared to those with 25(OH)D levels ≤ 50 nmol/L. It remains to be determined whether increasing Vitamin D levels in RA patients initially found to be Vitamin D deficient impacts their all-cause mortality.
 Download the PDF from VitaminDWiki


8 Meta-analyses of Rheumatoid Arthritis


2012 Review of Vitamin D and RA attached at the bottom of this page has the following image

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2014 study on Vitamin D and RA is attached at the bottom of this page


See also at VitaminDWiki - PAIN 


See also web

  • Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response - May 2019
  • Lower vitamin D in Saudia Arabia if RA not responding to treatment May 2012
  • The Key to Reversing All Autoimmune Diseases - Mercola Aug 2022
    • Rheumatoid Arthritis is reduced when vitamin D levels are 60-70 ng
    • And when Omega-6 (which blocks ((Overview: Omega-3 many benefits include helping vitamin D|Omega-3) )) is reduced
      • Saflower, Sunflower, Grapeseed, Corn, Soybean
  • Newer Drugs for Rheumatoid Arthritis All Have Similar Risks — Maybe It’s Time to Go Natural? Mercola Sept 2012
    I have personally treated over 3,000 patients with rheumatoid arthritis in my practice, which is well over 10 times the amount a typical family physician would treat in their entire career
    Latest additions: Naltrexone, Astaxanthin, Probiotics, regular exercise, Vitamin D
    Vitamin D deficiency is strongly associated with the development of RA.
    From my perspective, it is now virtually criminal negligent malpractice to treat a person with RA and not aggressively monitor their vitamin D levels to confirm that they are in a therapeutic range of 50-70 ng/ml.
  • Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis Nov 2012
  • Vitamin D in rheumatoid arthritis: panacea or placebo? Nov 2012, Full text online
    . . role of vitamin D in mediating various biological processes is well defined, this has not translated into meaningful clinical associations in RA.
  • Vitamin D and rheumatoid arthritis Dec 2012, RA had 15 ng, non-RA had 26 ng
    negative correlations between vitamin D and CRP (–0.115) and ESR (−0.18)
  • Serum vitamin D level and disease activity in patients with recent onset rheumatoid arthritis Oct 2013
    patients with more active RA have a lower serum vitamin D level
  • 46 Million in the U.S. have Arthritis Carolyn Dean July 2014; Sulfur, Magnesium, Boron, Calcium, Zinc, Manganese, Copper. Sulfur, which is found in my ReAline are important. no mention of Vitamin D
  • Vitamin D in rheumatoid arthritis—towards clinical application
    NATURE REVIEWS RHEUMATOLOGY - Oct 2015, PDF is available free at Sci-Hub  10.1038/nrrheum.2015.140
  • Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint - 2017
     Download the PDF from VitaminDWiki
  • A girl with RA who was taking methotrexate was able to stop after being on Coimbra Protocol for 4 months - June 2018
    Note: Protocol typically has a goal of a vitamin D level of 150 ng
    Her doctor had her stop the high vitamin D level, the RA came back 2 months later, she went back on the protocol
    click here to see text from Facebook

    Hi everybody I am a french patient (who lives in Italy) with my daughter (12 years old) of the doctor Giordo, for our arthritis, we follow the Coimbra protocol since September 2017, and we already noticed great results!

    My daughter from 4 months does not need anymore to take methotrexate for the first time!!! She took it since she was 4 years old...and each time doctors said us to remove it after 2 months her arthritis came back with pain and inflammation...

    I wrote to Cicero Coimbra to thank him and I told him I want to share my testimony to the french people who don't know his protocol!! and he kindly answered me the day after, glad I want to share his protocol in my country (I don't know why there is no french doctors who follow the coimbra protocol and no french group FB so I thought to create the first FB GROUP for french people in a FRENCH LANGUAGE!) >> "Protocole du Dr.Cicero G.Coimbra (vit D hautes doses) France" (if you want the link I can send you on messenger! Write me here or send me a PM)

    I hope there are FRENCH PEOPLE in this group who are reading me, maybe they want to sign up in the french group where I am the administrator and bring us their testimonies in french language, it would be fantastic!

    I NEED THE TESTIMONIES TO FRENCH PEOPLE IN THE WORLD AND IN FRANCE!

  • Interview and transcript: Vitamin D protocol for Autoimmune diseases – Dr. Coimbra 2016 - such as RA

Knee Joint with and without Rheumatoid Arthritis

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Note: Boron appears to repair and strengthen cartilage

Overview Rheumatoid Arthritis and vitamin D        
61012 visitors, last modified 11 Feb, 2024,
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Attached files

ID Name Comment Uploaded Size Downloads
20789 Methotrex mortality.png admin 11 Feb, 2024 198.37 Kb 53
20788 Methotrexate mortality_CompressPdf.pdf admin 11 Feb, 2024 276.30 Kb 15
11914 RA May 2019.pdf admin 07 May, 2019 1.81 Mb 1163
8587 T cells from the rheumatoid joint.pdf admin 26 Oct, 2017 2.08 Mb 1346
7442 Joint with and without RA.jpg admin 04 Dec, 2016 32.69 Kb 7394
4324 rheumatoid arthritis 2014.pdf admin 28 Aug, 2014 1,016.61 Kb 2739
1735 RA fig 1.jpg admin 25 Nov, 2012 28.45 Kb 22222
1734 RA and vitamin D review - 2012.pdf admin 25 Nov, 2012 637.53 Kb 2452