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Non-melanoma skin cancer varies with latitude, melanoma does not – April 2017

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

ONCOLOGY LETTERS 13: 3787-3792, 2017 DOI: 10.3892/ol.2017.5898
MIGUEL RIVAS1, ELISA ROJAS1, GLORIA M. CALAF2,3 gmc24 at columbia.edu, MARCELA BARBERAN4, CLAUDIO LIBERMAN4 and MARCELO DE PAULA CORREA5
1 2 Department of Physics, Faculty of Science; Institute for Advanced Research, Tarapaca University,Arica 8097877, 3 Chile; Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA; 4 Endocrinology and Diabetes Section, Clinical Hospital of University of Chile, Santiago 8320000, Chile; 5 Natural Resources Institute, Federal University of Itajuba, Itajuba, MG 37500-000, Brazil


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Non-melanoma

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Vitamin D synthesis takes place in the skin due to solar ultraviolet-B (UVB) radiation. Several studies have shown the association between low sun exposure, non-melanoma skin cancer (NMSC) and a lack of vitamin D synthesis. Since such synthesis in the body depends on the exposure of the skin to solar UVB radiation (290-320 nm), experimental measurements of this type of solar radiation are important. Tarapaca University in Arica, Chile, established a solar UV radiation laboratory in 2006 and since then this laboratory has performed systematic experimental solar UVB measurements using a calibrated biometer instrument. The results, which are presented in the current study, showed the association between NMSC and MSC rates, and the time required to produce 1,000 IU vitamin D with latitudinal variation. Solar UV index (UVI) levels reported in 6 cities from the north to the south of Chile indicated that the UVI ratio of monthly mean values was 1.8 times higher in Arica than in Punta Arenas in January (summer in Chile), whereas it was 14 times higher in June (winter). This factor is an important consideration, since vitamin D synthesis is directly associated with the exposure of individuals to solar UVB radiation. A similar trend was observed in Antofagasta, Santiago, Concepcion, Valdivia and Punta Arenas. It can be concluded from these data that there is a direct association between NMSC rates and mortality, and UVB radiation, meaning that this type of cancer would not depend on vitamin D synthesis and therefore on calcium uptake. By contrast, MSC rates increased with decreased levels of vitamin D, and thus calcium uptake, in all cities, with the only exception being Punta Arenas.

Created by admin. Last Modification: Tuesday May 23, 2017 01:08:44 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
8019 Skin Cancer types vs latitude.pdf PDF 2017 admin 23 May, 2017 00:27 798.55 Kb 119
8018 MSC.jpg admin 23 May, 2017 00:27 17.81 Kb 166
8017 NMSC.jpg admin 23 May, 2017 00:26 16.40 Kb 200
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